Resveratrol alleviates Mono-2-ethylhexyl phthalate-induced mitophagy, ferroptosis, and immunological dysfunction in grass carp hepatocytes by regulating the Nrf2 pathway

Journal of Environmental Management, Год журнала: 2024, Номер 371, С. 123235 - 123235

Опубликована: Ноя. 6, 2024

Язык: Английский

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Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus

Journal of Environmental Sciences, Год журнала: 2024, Номер 148, С. 13 - 26

Опубликована: Янв. 21, 2024

Язык: Английский

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Deciphering the molecular mechanism of NLRP3 in BPA-mediated toxicity: Implications for targeted therapies

Heliyon, Год журнала: 2024, Номер 10(7), С. e28917 - e28917

Опубликована: Март 30, 2024

Bisphenol-A (BPA), a pervasive industrial chemical used in polymer synthesis, is found numerous consumer products including food packaging, medical devices, and resins. Detectable majority of the global population, BPA exposure occurs via ingestion, inhalation, dermal routes. Extensive research has demonstrated adverse health effects BPA, particularly its disruption immune endocrine systems, along with genotoxic potential. This review focuses on complex relationship between NOD-like receptor protein 3 (NLRP3) inflammasome, multiprotein central to inflammatory disease processes. We examine how induces oxidative stress through generation intracellular free radicals, subsequently activating NLRP3 signaling. The mechanistic details this process are explored, involvement signaling cascades such as PI3K/AKT, JAK/STAT, AMPK/mTOR, ERK/MAPK, which implicated inflammasome activation. A key focus wide-ranging organ toxicities associated exposure, hepatic, renal, gastrointestinal, cardiovascular dysfunction. investigate immunopathogenesis molecular pathways driving these injuries, highlighting interplay among stress, inflammasome. Finally, explores emerging concept targeting potential therapeutic strategy mitigate stemming from exposure. work integrates current knowledge, emphasizes mechanisms, promotes further into NLRP3-targeted interventions.

Язык: Английский

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Phthalate drives splenic inflammatory response via activating HSP60/TLR4/NLRP3 signaling axis-dependent pyroptosis

Environmental Pollution, Год журнала: 2024, Номер 346, С. 123610 - 123610

Опубликована: Фев. 19, 2024

Язык: Английский

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Musa basjoo Sieb polysaccharide improves inflammation in RAW264.7 cells and zebrafish colitis

Food Bioscience, Год журнала: 2024, Номер 61, С. 104471 - 104471

Опубликована: Июнь 4, 2024

Язык: Английский

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Farnesol attenuates cadmium-induced kidney injury by mitigating oxidative stress, inflammation and necroptosis and upregulating cytoglobin and PPARγ in rats

Tissue and Cell, Год журнала: 2024, Номер 90, С. 102526 - 102526

Опубликована: Авг. 17, 2024

Язык: Английский

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New insights into quercetin's attenuation of TBBPA-induced injury to MCEC cells: Involvement of the p38/NF-κB pathway and pyroptosis

Journal of Environmental Management, Год журнала: 2025, Номер 376, С. 124425 - 124425

Опубликована: Фев. 10, 2025

Язык: Английский

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Establishment of the Tgf2-based anti-hemorrhagic disease system THVS and analysis of its disease resistance effects in Gobiocypris rarus

Fish & Shellfish Immunology, Год журнала: 2025, Номер unknown, С. 110206 - 110206

Опубликована: Фев. 1, 2025

Язык: Английский

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Quercetin attenuates DEHP-induced pyroptosis and programmed necrosis in chicken duodenum through regulation of the TLR4/MyD88/NF-κB pathway

Environmental Pollution, Год журнала: 2025, Номер 372, С. 126016 - 126016

Опубликована: Март 6, 2025

Язык: Английский

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Evodiamine Promotes Autophagy and Alleviates Oxidative Stress in Dry Eye Disease Through the p53/mTOR Pathway

Investigative Ophthalmology & Visual Science, Год журнала: 2025, Номер 66(3), С. 44 - 44

Опубликована: Март 20, 2025

Purpose: This study aims to explore the therapeutic efficacy of evodiamine (EVO) in treatment dry eye disease (DED). Methods: Mouse models DED was developed using benzalkonium chloride drops and subcutaneous atropine injections. Corneal epithelial defects were assessed by fluorescein sodium staining, tear secretion measured with phenol red thread test. For vitro model, human corneal cells cultured a chloride–enriched medium. Phenotypic mechanistic analyses conducted real-time quantitative PCR, Western blotting, flow cytometry, immunofluorescence staining. Results: The administration EVO significantly enhanced mice, ameliorated ocular surface damage, decreased expression inflammatory factors, increased density conjunctival goblet cells. Furthermore, reduced oxidative stress promoting autophagy. Mechanistically, EVO-induced autophagy mediated via p53/mammalian target rapamycin pathway. Conclusions: These findings suggest that is potential agent for DED, its beneficial effects attributed activation through

Язык: Английский

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