Heliyon,
Journal Year:
2024,
Volume and Issue:
10(7), P. e28917 - e28917
Published: March 30, 2024
Bisphenol-A
(BPA),
a
pervasive
industrial
chemical
used
in
polymer
synthesis,
is
found
numerous
consumer
products
including
food
packaging,
medical
devices,
and
resins.
Detectable
majority
of
the
global
population,
BPA
exposure
occurs
via
ingestion,
inhalation,
dermal
routes.
Extensive
research
has
demonstrated
adverse
health
effects
BPA,
particularly
its
disruption
immune
endocrine
systems,
along
with
genotoxic
potential.
This
review
focuses
on
complex
relationship
between
NOD-like
receptor
protein
3
(NLRP3)
inflammasome,
multiprotein
central
to
inflammatory
disease
processes.
We
examine
how
induces
oxidative
stress
through
generation
intracellular
free
radicals,
subsequently
activating
NLRP3
signaling.
The
mechanistic
details
this
process
are
explored,
involvement
signaling
cascades
such
as
PI3K/AKT,
JAK/STAT,
AMPK/mTOR,
ERK/MAPK,
which
implicated
inflammasome
activation.
A
key
focus
wide-ranging
organ
toxicities
associated
exposure,
hepatic,
renal,
gastrointestinal,
cardiovascular
dysfunction.
investigate
immunopathogenesis
molecular
pathways
driving
these
injuries,
highlighting
interplay
among
stress,
inflammasome.
Finally,
explores
emerging
concept
targeting
potential
therapeutic
strategy
mitigate
stemming
from
exposure.
work
integrates
current
knowledge,
emphasizes
mechanisms,
promotes
further
into
NLRP3-targeted
interventions.
Investigative Ophthalmology & Visual Science,
Journal Year:
2025,
Volume and Issue:
66(3), P. 44 - 44
Published: March 20, 2025
Purpose:
This
study
aims
to
explore
the
therapeutic
efficacy
of
evodiamine
(EVO)
in
treatment
dry
eye
disease
(DED).
Methods:
Mouse
models
DED
was
developed
using
benzalkonium
chloride
drops
and
subcutaneous
atropine
injections.
Corneal
epithelial
defects
were
assessed
by
fluorescein
sodium
staining,
tear
secretion
measured
with
phenol
red
thread
test.
For
vitro
model,
human
corneal
cells
cultured
a
chloride–enriched
medium.
Phenotypic
mechanistic
analyses
conducted
real-time
quantitative
PCR,
Western
blotting,
flow
cytometry,
immunofluorescence
staining.
Results:
The
administration
EVO
significantly
enhanced
mice,
ameliorated
ocular
surface
damage,
decreased
expression
inflammatory
factors,
increased
density
conjunctival
goblet
cells.
Furthermore,
reduced
oxidative
stress
promoting
autophagy.
Mechanistically,
EVO-induced
autophagy
mediated
via
p53/mammalian
target
rapamycin
pathway.
Conclusions:
These
findings
suggest
that
is
potential
agent
for
DED,
its
beneficial
effects
attributed
activation
through
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Apigenin
(API)
is
a
flavonoid
widely
distributed
in
vegetables
and
fruits
that
exhibits
numerous
biological
functions.
Lipopolysaccharide
(LPS),
key
component
of
the
outer
membrane
Gram-negative
bacteria,
can
cause
kidney
injury
when
released
into
bloodstream.
Necroptosis
form
programmed
cell
death
characterized
by
rupture
membranes.
Excessive
occurrence
necroptosis
lead
to
substantial
damage
cells
tissues.
In
study,
we
discovered
API
could
mitigate
LPS-induced
mice
alleviate
Normal
Rat
Kidney-52E
(NRK-52E)
targeting
mitochondrial
reactive
oxygen
species
(mtROS)-RIPK3-MLKL
pathway.
Further
mechanistic
studies
revealed
potentially
activate
endosomal
sorting
complexes
required
for
transport-III
(ESCRT-III),
activated
ESCRT-III
repair
caused
necroptosis.
Simultaneously,
promote
mitophagy,
which
facilitates
timely
removal
damaged
mitochondria
reduces
intracellular
mtROS
levels.
conclusion,
our
results
suggested
alleviates
renal
activating
ESCRT-III-dependent
mitophagy.
Our
study
provides
new
insights
daily
dietary
intake
LPS.
