Foods,
Год журнала:
2024,
Номер
13(24), С. 4176 - 4176
Опубликована: Дек. 23, 2024
Type
2
diabetes
mellitus
(T2DM)
and
cancer
are
significant
contributors
to
morbidity
mortality
worldwide.
Recent
studies
have
increasingly
highlighted
the
potential
of
phytochemicals
found
in
plants
plant-based
foods
for
preventing
treating
these
chronic
diseases.
Mexico’s
agrobiodiversity
provides
a
valuable
resource
phytochemistry.
This
review
presents
an
examination
essential
within
Mexican
that
shown
promising
anti-cancer
anti-diabetic
properties,
including
their
roles
as
antioxidants,
insulin
sensitizers,
enzyme
inhibitors.
Notable
compounds
identified
include
flavonoids
(such
quercetin
catechins),
phenolic
acids
(chlorogenic,
gallic,
caffeic
acids),
methylxanthines
(like
theobromine),
xanthones
mangiferin),
capsaicinoids
(capsaicin),
organosulfur
alliin),
various
lipids
(avocatins).
Although
promise
laboratory
animal
studies,
there
is
scarcity
clinical
trial
data
involving
humans,
underscoring
important
area
future
research.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 9118 - 9118
Опубликована: Авг. 22, 2024
The
intricate
interplay
between
the
gut
microbiota
and
polyphenols
has
emerged
as
a
captivating
frontier
in
understanding
potentially
harnessing
therapeutic
potential
of
these
bioactive
compounds.
Phenolic
compounds,
renowned
for
their
antioxidant,
anti-inflammatory,
antidiabetic,
anticancer
properties,
are
subject
to
transformations
within
milieu,
where
diverse
microbial
ecosystem
exerts
profound
effects
on
metabolism
bioavailability.
Conversely,
exhibit
remarkable
capacity
modulate
composition
activity
microbiota,
fostering
bidirectional
relationship
that
extends
beyond
mere
nutrient
processing.
This
symbiotic
interaction
holds
significant
implications
human
health,
particularly
cardiometabolic
diseases
such
diabetes
mellitus,
metabolic-dysfunction-associated
steatotic
liver
disease,
cardiovascular
disease.
Through
comprehensive
exploration
molecular
interactions,
this
narrative
review
elucidates
reciprocal
dynamics
polyphenols,
unveiling
novel
avenues
intervention
disorders.
By
unravelling
cross-talk
two
entities,
underscores
multifaceted
roles
overall
health
pivotal
role
modulation
promising
strategy
mitigating
burden
diseases.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(10), С. 1354 - 1354
Опубликована: Окт. 10, 2024
Metabolic-Associated
Fatty
Liver
Disease
(MAFLD)
is
a
clinical-pathological
scenario
that
occurs
due
to
the
accumulation
of
triglycerides
in
hepatocytes
which
considered
significant
cause
liver
conditions
and
contributes
an
increased
risk
death
worldwide.
Even
though
possible
causes
MAFLD
can
involve
interaction
genetics,
hormones,
nutrition,
lifestyle
(diet
sedentary
lifestyle)
most
influential
factor
developing
this
condition.
Polyphenols
comprise
many
natural
chemical
compounds
be
helpful
managing
metabolic
diseases.
Therefore,
aim
review
was
investigate
impact
oxidative
stress,
inflammation,
mitochondrial
dysfunction,
role
polyphenols
MAFLD.
Some
reverse
part
damage
related
or
among
them
are
anthocyanin,
baicalin,
catechin,
curcumin,
chlorogenic
acid,
didymin,
epigallocatechin-3-gallate,
luteolin,
mangiferin,
puerarin,
punicalagin,
resveratrol,
silymarin.
These
have
actions
reducing
plasma
enzymes,
body
mass
index,
waist
circumference,
adipose
visceral
indices,
lipids,
glycated
hemoglobin,
insulin
resistance,
HOMA
index.
They
also
reduce
nuclear
factor-KB
(NF-KB),
interleukin
(IL)-1β,
IL-6,
tumor
necrosis
factor-α
(TNF-α),
blood
pressure,
fat
content,
steatosis
fibrosis.
On
other
hand,
they
improve
HDL-c,
adiponectin
levels,
fibrogenesis
markers.
results
show
promising
prevention
treatment
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2025,
Номер
24(2)
Опубликована: Март 1, 2025
Antibiotics
are
effective
in
treating
bacterial
infections,
but
their
widespread
use
has
spurred
antibiotic
resistance,
which
is
linked
closely
with
human
disease.
While
dietary
components
known
to
influence
the
gut
microbiome,
specific
effects
on
resistome-the
collection
of
antibiotic-resistant
genes
gut-remain
underexplored.
This
review
outlines
mechanisms
action
and
development
emphasizing
connection
between
resistome
diseases
such
as
metabolic
disorders,
cardiovascular
disease,
liver
nervous
system
disorders.
It
also
discusses
diet
habits
components,
including
bioactive
macronutrients,
phytochemicals,
probiotics,
composition
by
enhancing
efficacy
potentially
reducing
resistance.
highlights
emerging
trend
increasing
interest
functional
foods
aimed
at
targeting
a
growing
focus
plant
compounds
potential
modulate
