Antioxidants, Год журнала: 2024, Номер 13(11), С. 1314 - 1314
Опубликована: Окт. 29, 2024
During the past few years, researchers have dedicated themselves to studying phytochemicals which make up nutritional and non-nutritional bioactive compounds found in fruits, vegetables, cereals, other plant foods [...].
Язык: Английский
Antioxidants, Год журнала: 2024, Номер 13(12), С. 1508 - 1508
Опубликована: Дек. 10, 2024
Healthcare professionals frequently experience significant work overload, which often leads to substantial physical and psychological stress. This stress is closely linked increased oxidative a corresponding decline in energy levels. scoping review investigates the potential impact of dietary antioxidants food supplements conjunction with diet controlling these negative effects. Through an analysis biochemical pathways involved metabolism, paper emphasizes effectiveness targeted interventions. Key antioxidants, such as vitamins C E, polyphenols, carotenoids, are evaluated for their ability counteract enhance Additionally, assesses various supplements, including omega-3 fatty acids, coenzyme Q10, ginseng, mechanisms action enhancement. Practical guidelines incorporating energy-boost strategies into routine healthcare provided, emphasizing importance modifications reducing improving overall well-being performance high-stress environments. The concludes by suggesting directions future research validate findings explore new interventions that may further support under overload.
Язык: Английский
Процитировано
5
Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Фев. 18, 2025
The gut microbiome plays a pivotal role in human health, influencing digestion, immunity, and disease prevention. Beneficial bacteria such as Akkermansia muciniphila, Adlercreutzia equolifaciens, Christensenella minuta contribute to metabolic regulation immune support through bioactive metabolites like short-chain fatty acids (SCFAs). Dietary patterns rich prebiotics, fermented foods, plant-based compounds, including polyphenols flavonoids, promote diversity stability. However, challenges individual variability, bioavailability, dietary adherence, the dynamic nature of microbiota remain significant. This review synthesizes current insights into bacteria's emphasizing mechanisms by which interventions modulate microbiota. Additionally, it highlights advancements microbiome-targeted therapies transformative potential personalized nutrition, leveraging profiling artificial intelligence (AI) develop tailored strategies for optimizing health mitigating chronic inflammatory disorders. Addressing these requires multidisciplinary approach that integrates scientific innovation, ethical frameworks, practical implementation strategies.
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106251 - 106251
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2895 - 2895
Опубликована: Март 22, 2025
Psoriasis is a chronic immune-mediated skin disease characterized by cytokine dysregulation. Pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-17, and IL-23, play pivotal roles in the pathogenesis of psoriasis. Emerging evidence suggests that dietary interventions can modulate activity, providing complementary approach to standard therapies. This narrative review examines impact various strategies, Mediterranean diet, ketogenic gluten-free fasting-mimicking on profiles clinical outcomes Research insights reveal components such as omega-3 fatty acids, polyphenols, short-chain acids influence immune signaling pathways. These pathways include nuclear factor-kappa B (NF-κB) Signal Transducer Activator Transcription 3 (STAT3). Additionally, these promote anti-inflammatory effects mediated gut microbiota. Clinical studies demonstrate significant reductions psoriasis severity, improved quality life, modulation key cytokines associated with activity. Despite advancements, challenges persist effectively integrating findings into practice. variability patient responses, adherence issues, need for robust biomarkers monitor efficacy. Future directions emphasize potential personalized nutrition precision medicine approaches optimize tailored individual genetic predispositions. Integrating strategies care could transform treatment paradigms simultaneously addressing both systemic inflammation comorbid conditions.
Язык: Английский
Процитировано
0
Food and Humanity, Год журнала: 2025, Номер unknown, С. 100602 - 100602
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Food Science & Nutrition, Год журнала: 2025, Номер 13(4)
Опубликована: Апрель 1, 2025
ABSTRACT Exosome‐like nanovesicles derived from plants (PENs) harbor a spectrum of bioactive compounds, including proteins, lipids, nucleic acids (such as miRNAs and mRNAs), offering therapeutic advantages for variety diseases. This investigation assesses the utility pomegranate‐derived exosome‐like (PNVs) in both preventing treating complications such liver damage increased intestinal permeability found Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD). Utilizing Transmission Electron Microscopy (TEM) Nanoparticle Tracking Analysis (NTA), we successfully isolated PNVs characterized their structural properties. Upon administration live model, these were efficiently distributed to critical organs, intestines, demonstrating biocompatibility by avoiding toxic effects. Remarkably, vesicles enriched with ellagic acid, known its strong antioxidant capabilities. In controlled MASLD mouse study, treatment significantly lowered serum endotoxin levels, reinforced barrier functions, altered gut microbiota profile favorably. Furthermore, application reduced oxidative stress presence fibrosis markers normal levels. These results indicate that could be viable option addressing MASLD, enhancing integrity, reducing injury, diminishing through modulation gut‐liver axis.
Язык: Английский
Процитировано
0
Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Апрель 15, 2025
With growing recognition of the pivotal role gut microbiota in human health, probiotics have gained widespread attention for their potential to restore microbial homeostasis. However, a critical challenge persists: limited colonization efficiency among most probiotic strains compromises therapeutic efficacy. This overview synthesizes ecological principles with cutting-edge microbiome research elucidate dynamic interplay between dietary components and within intestinal niche. systematically analyzes: (1) stage-specific mechanisms spanning introduction, establishment, proliferation; (2) nutrient-driven modulation composition function; (3) dual common patterns as both facilitators disruptors persistence. Notably, this identifies key strategies, including precision delivery prebiotic fibers polyphenol-microbiota crosstalk, that enhance niche adaptation through pH optimization, adhesion potentiation, competitive exclusion pathogens. Furthermore, critically evaluates current limitations research, particularly strain-specific variability methodological constraints simulating host-microbe-diet tripartite interactions. To bridge these gaps, proposes an interdisciplinary framework integrating omics-driven strain selection, engineered systems, personalized nutrition models. Collectively, work advances mechanistic understanding diet-microbiota interactions while providing actionable insights developing targeted therapies evidence-based interventions optimize ecosystem resilience.
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2024, Номер 13(11), С. 1314 - 1314
Опубликована: Окт. 29, 2024
During the past few years, researchers have dedicated themselves to studying phytochemicals which make up nutritional and non-nutritional bioactive compounds found in fruits, vegetables, cereals, other plant foods [...].
Язык: Английский
Процитировано
1