Epitranscriptomics in the Glioma Context: A Brief Overview

Cancers, Год журнала: 2025, Номер 17(4), С. 578 - 578

Опубликована: Фев. 8, 2025

Epitranscriptomics, the study of chemical modifications in RNA, has emerged as a crucial field cellular regulation, adding another layer to established landscape DNA- and histone-based epigenetics. A wide range RNA modifications, including N6-methyladenosine, pseudouridine, inosine, have been identified across nearly all species, influencing essential processes such transcription, splicing, stability, translation. In context brain tumors, particularly gliomas, specific epitranscriptomic signatures reported play role tumorigenesis. Despite growing evidence, biological implications various remain poorly understood. This review offers an examination main interplay between modified unmodified molecules, how they could contribute glioma-like phenotypes, therapeutic impact targeting these mechanisms.

Язык: Английский

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ADAR1 Promotes NUPR1 A-to-I RNA Editing to Exacerbate Ischemic Brain Injury by Microglia Mediated Neuroinflammation

NeuroMolecular Medicine, Год журнала: 2025, Номер 27(1)

Опубликована: Фев. 26, 2025

Язык: Английский

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N6-methyladenosine in inflammatory diseases: Important actors and regulatory targets

Gene, Год журнала: 2024, Номер 936, С. 149125 - 149125

Опубликована: Ноя. 27, 2024

Язык: Английский

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Editorial overview: Epitranscriptomics: Exploring a new frontier in health and disease

Current Opinion in Genetics & Development, Год журнала: 2024, Номер 89, С. 102271 - 102271

Опубликована: Окт. 24, 2024

Язык: Английский

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