Epitranscriptomics in the Glioma Context: A Brief Overview

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 578 - 578

Published: Feb. 8, 2025

Epitranscriptomics, the study of chemical modifications in RNA, has emerged as a crucial field cellular regulation, adding another layer to established landscape DNA- and histone-based epigenetics. A wide range RNA modifications, including N6-methyladenosine, pseudouridine, inosine, have been identified across nearly all species, influencing essential processes such transcription, splicing, stability, translation. In context brain tumors, particularly gliomas, specific epitranscriptomic signatures reported play role tumorigenesis. Despite growing evidence, biological implications various remain poorly understood. This review offers an examination main interplay between modified unmodified molecules, how they could contribute glioma-like phenotypes, therapeutic impact targeting these mechanisms.

Language: Английский

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ADAR1 Promotes NUPR1 A-to-I RNA Editing to Exacerbate Ischemic Brain Injury by Microglia Mediated Neuroinflammation

NeuroMolecular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: Feb. 26, 2025

Language: Английский

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N6-methyladenosine in inflammatory diseases: Important actors and regulatory targets

Gene, Journal Year: 2024, Volume and Issue: 936, P. 149125 - 149125

Published: Nov. 27, 2024

Language: Английский

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Editorial overview: Epitranscriptomics: Exploring a new frontier in health and disease

Current Opinion in Genetics & Development, Journal Year: 2024, Volume and Issue: 89, P. 102271 - 102271

Published: Oct. 24, 2024

Language: Английский

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