ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
11(2), С. 784 - 805
Опубликована: Янв. 30, 2025
Myocardial
infarction
(MI),
a
severe
cardiovascular
condition,
is
typically
triggered
by
coronary
artery
disease,
resulting
in
ischemic
damage
and
the
subsequent
necrosis
of
myocardium.
Macrophages,
known
for
their
remarkable
plasticity,
are
capable
exhibiting
range
phenotypes
functions
as
they
react
to
diverse
stimuli
within
local
microenvironment.
In
recent
years,
there
has
been
an
increasing
number
studies
on
regulation
macrophage
behavior
based
tissue
engineering
strategies,
its
regulatory
mechanisms
deserve
further
investigation.
This
review
first
summarizes
effects
key
factors
engineered
biomaterials
(including
bioactive
molecules,
conductivity,
some
microenvironmental
factors)
behavior,
then
explores
specific
methods
inducing
through
materials
promote
myocardial
repair,
role
macrophage-host
cell
crosstalk
regulating
inflammation,
vascularization,
remodeling.
Finally,
we
propose
future
challenges
macrophage-material
interactions
tailoring
personalized
guide
phenotypes.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(2), С. 195 - 195
Опубликована: Фев. 1, 2024
Hypoxia-inducible
factor-1
(HIF-1)
is
a
key
regulator
for
balancing
oxygen
in
the
cells.
It
transcription
factor
that
regulates
expression
of
target
genes
involved
homeostasis
response
to
hypoxia.
Recently,
research
has
demonstrated
multiple
roles
HIF-1
pathophysiology
various
diseases,
including
cancer.
crucial
mediator
hypoxic
and
metabolism,
thus
contributing
tumor
development
progression.
Studies
showed
HIF-1α
subunit
significantly
upregulated
cancer
cells
promotes
survival
by
mechanisms.
In
addition,
potential
progression,
cell
division,
survival,
proliferation,
angiogenesis,
metastasis.
Moreover,
role
regulating
cellular
metabolic
pathways,
particularly
anaerobic
metabolism
glucose.
Given
its
significant
it
been
an
intriguing
therapeutic
research.
Several
compounds
targeting
HIF-1-associated
processes
are
now
being
used
treat
different
types
This
review
outlines
emerging
strategies
as
well
relevance
regulation
pathways
addresses
employment
nanotechnology
developing
these
promising
strategies.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3313 - 3313
Опубликована: Март 14, 2024
Hypoxia-inducible
factor-1α
(HIF-1α)
is
a
major
transcriptional
factor,
which
plays
an
important
role
in
cellular
reprogramming
processes
under
hypoxic
conditions,
facilitate
solid
tumors'
progression.
HIF-1α
directly
involved
the
regulation
of
angiogenesis,
metabolic
reprogramming,
and
extracellular
matrix
remodeling
tumor
microenvironment.
Therefore,
in-depth
study
on
malignancies
required
to
develop
novel
anti-cancer
therapeutics.
also
critical
regulating
growth
factors,
such
as
vascular
endothelial
fibroblast
platelet-derived
network
manner.
Additionally,
it
significant
progression
chemotherapy
resistance
by
variety
angiogenic
including
angiopoietin
1
2,
metalloproteinase,
erythropoietin,
along
with
energy
pathways.
this
review
attempts
provide
comprehensive
insight
into
angiogenesis
pathways
tumors.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2060 - 2060
Опубликована: Фев. 8, 2024
In
the
realm
of
cancer
therapeutics,
targeting
hypoxia-inducible
factor
(HIF)
pathway
has
emerged
as
a
promising
strategy.
This
study
delves
into
intricate
web
HIF-associated
mechanisms,
exploring
avenues
for
future
anticancer
therapies.
Framing
investigation
within
broader
context
progression
and
hypoxia
response,
this
article
aims
to
decipher
pivotal
role
played
by
HIF
in
regulating
genes
influencing
angiogenesis,
cell
proliferation,
glucose
metabolism.
Employing
diverse
approaches
such
inhibitors,
anti-angiogenic
therapies,
hypoxia-activated
prodrugs,
research
methodologically
intervenes
at
different
nodes
pathway.
Findings
showcase
efficacy
agents
like
EZN-2968,
Minnelide,
Acriflavine
modulating
HIF-1α
protein
synthesis
destabilizing
HIF-1,
providing
preliminary
proof
mRNA
modulation
antitumor
activity.
However,
challenges,
including
toxicity,
necessitate
continued
exploration
development,
exemplified
ongoing
clinical
trials.
concludes
emphasizing
potential
targeted
therapies
disrupting
cancer-related
signaling
pathways.
Triple-negative
breast
cancer
(TNBC)
is
among
the
most
aggressive
forms
of
cancer,
characterized
by
a
dismal
prognosis.
In
absence
drug-targetable
receptors,
chemotherapy
remains
sole
systemic
treatment
alternative.
Recent
advancements
in
immunotherapy,
particularly
immune
checkpoint
inhibitors
(ICIs)
that
target
programmed
death
1/programmed
ligand
1
(PD-1/PD-L1)
and
cytotoxic
T
lymphocyte
associated
antigen
4
(CTLA-4),
have
provided
renewed
optimism
for
patients
with
TNBC.
Prior
research
has
indicated
expression
level
cell
polarity
protein
discs
large
homolog
5
(DLG5)
correlates
malignant
progression
prognosis
cancer;
nevertheless,
its
influence
on
PD-L1
function
immunotherapy
TNBC
require
further
investigation.
The
hypoxia
model
was
established
simulating
hypoxic
microenvironment
human
SUM159
MDA-MB-231
lines
using
cobalt
II
chloride
(CoCl2).
A
combination
DLG5
RNA
interference
techniques
used,
along
various
methods
including
counting
kit-8
(CCK-8),
colony
formation,
wound
healing,
transwell
migration,
reverse
transcription-quantitative
real-time
PCR
(RT-qPCR),
immunofluorescence,
immunohistochemical
staining
(IHC),
analysis
from
datasets
western
blotting.
These
were
employed
to
evaluate
changes
proliferation,
levels
DLG5.
Additionally,
correlation
between
clinical
samples
analyzed.
(1)
vitro
experiments,
cellular
effectively
utilizing
150
µM
CoCl₂.
Under
these
conditions,
clone
invasiveness,
migration
rate
all
significantly
inhibited.
(2)
increased
both
cells
following
(3)
Silencing
resulted
considerable
upregulation
under
normoxic
circumstances,
but
it
markedly
downregulated
settings.
Inhibition
increase
decreased
conditions.
Correlation
demonstrated
an
inverse
association
tissues.
This
study
provides
new
theoretical
evidence
potential
therapeutic
targets
strategies
TNBC,
holding
significant
application
value.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 6, 2025
The
hypoxia-inducible
factor-1α
(HIF-1α)
plays
a
key
role
in
facilitating
the
adaptation
of
cells
to
hypoxia,
profoundly
influencing
immune
vascular
microenvironment
(IVM)
and
immunotherapy
outcomes.
HIF-1α-mediated
tumor
hypoxia
drives
angiogenesis,
suppression,
extracellular
matrix
remodeling,
creating
an
environment
that
promotes
progression
resistance
immunotherapies.
HIF-1α
regulates
critical
pathways,
including
expression
endothelial
growth
factor
checkpoint
upregulation,
leading
tumor-infiltrating
lymphocyte
dysfunction
recruitment
immunosuppressive
like
regulatory
T
myeloid-derived
suppressor
cells.
These
alterations
reduce
efficacy
inhibitors
other
Recent
studies
highlight
therapeutic
strategies
target
HIF-1α,
such
as
use
pharmacological
inhibitors,
gene
editing
techniques,
hypoxia-modulating
treatments,
which
show
promise
enhancing
responses
immunotherapy.
This
review
explores
molecular
mechanisms
action
IVM,
its
impact
on
resistance,
well
potential
interventions,
emphasizing
need
for
innovative
approaches
circumvent
hypoxia-driven
immunosuppression
cancer
therapy.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 24, 2024
Osteosarcoma
(OS)
is
a
malignant
tumor
originating
from
mesenchymal
tissue.
Pulmonary
metastasis
usually
present
upon
initial
diagnosis,
and
the
primary
factor
affecting
poor
prognosis
of
patients
with
OS.
Current
research
shows
that
ability
to
regulate
cellular
microenvironment
essential
for
preventing
distant
OS,
anoxic
microenvironments
are
important
features
solid
tumors.
During
hypoxia,
hypoxia-inducible
factor-1α
(HIF-1α)
expression
levels
stability
increase.
Increased
HIF-1α
promotes
vascular
remodeling,
epithelial-mesenchymal
transformation
(EMT),
OS
cells
invasiveness;
this
leads
cells.
plays
an
role
in
mechanisms
metastasis.
In
order
develop
precise
prognostic
indicators
potential
therapeutic
targets
treatment,
review
examines
molecular
cells;
signal
transduction
pathways
mediated
by
also
discussed.
Heliyon,
Год журнала:
2024,
Номер
10(2), С. e24664 - e24664
Опубликована: Янв. 1, 2024
The
incidence
of
cervical
cancer
ranks
second
among
malignant
tumors
in
women,
exerting
a
significant
impact
on
their
quality
life
and
overall
well-being.
hypoxic
microenvironment
plays
pivotal
role
the
initiation
progression
tumorigenesis.
present
study
aims
to
investigate
fundamental
genes
pathways
associated
with
hypoxia-inducible
factor
(HIF-1A)
cancer,
aiming
identify
potential
downstream
targets
for
diagnostic
therapeutic
purposes.
The
integration
of
small
interfering
RNA
(siRNA)
with
traditional
cancer
therapies
represents
a
promising
frontier
in
oncology
aimed
at
enhancing
treatment
effectiveness,
reducing
side
effects,
and
overcoming
drug
resistance.
This
review
highlights
the
potential
siRNA
to
selectively
silence
genes
that
are
overexpressed
or
uniquely
expressed
cells,
thereby
disrupting
critical
pathways
support
tumor
growth
survival.
Key
target
discussed
include
survivin,
VEGF,
EGFR,
c-MET,
HER2,
MUC1,
Bcl-2,
all
which
play
vital
roles
proliferation,
angiogenesis,
resistance
therapies.
Clinical
trials
investigating
various
candidates,
such
as
EZN-3042
ALN-VSP,
indicate
these
generally
well-tolerated;
however,
significant
challenges
persist,
including
effective
delivery
stability
siRNA.
Recent
advancements
nanoparticle-based
systems
have
shown
promise
addressing
issues.
Future
research
will
focus
on
optimizing
methods,
personalizing
based
individual
genetic
profiles,
establishing
clearer
regulatory
guidelines
for
approval.
As
field
evolves,
siRNA-based
combination
poised
become
an
integral
part
precision
oncology,
offering
new
therapeutic
options
hope
patients
difficult-to-treat
cancers.
