Deciphering the molecular pathways of saroglitazar: A dual PPAR α/γ agonist for managing metabolic NAFLD

Metabolism, Год журнала: 2024, Номер 155, С. 155912 - 155912

Опубликована: Апрель 11, 2024

Язык: Английский

---

Involvement of intestinal mucosal microbiota in adenine-induced liver function injury

3 Biotech, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 12, 2024

Язык: Английский

---

The Essential Role of Mitochondrial Dynamics in Viral Infections

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1955 - 1955

Опубликована: Фев. 24, 2025

Mitochondria are dynamic organelles that play crucial roles in energy production, metabolic balance, calcium homeostasis, apoptosis, and innate immunity, key determinants of cell fate. They also targets for viral invasion the body. Many proteins target mitochondria, controlling mitochondrial morphology, metabolism, immune response, thereby achieving evasion, promoting their proliferation, accelerating infection process. Mitochondrial quality control is to maintaining normal physiological functions homeostasis. Dysregulation dynamics closely related development many diseases. New constantly being discovered. Viruses change by targeting mitochondria achieve a persistent state infection. Currently, understanding during limited. Research on impact provides foundation investigating pathogenesis infections, disease process, identifying potential therapeutic targets. This review focuses connection between priority areas research virus-mediated insight into regulation viruses explores means mitochondrial-mediated treatment

Язык: Английский

---

Mitochondrial Dysfunction in Endothelial Cells: A Key Driver of Organ Disorders and Aging

Antioxidants, Год журнала: 2025, Номер 14(4), С. 372 - 372

Опубликована: Март 21, 2025

Mitochondria are of great importance in cell biology since they major sites adenosine triphosphate (ATP) production and widely involved different cellular pathways the response to stress. During ATP production, reactive oxygen species (ROS) can be produced. While a small amount ROS may important for regulation physiological processes, at elevated levels turn into harmful agents leading damage. From pathological perspective, it could particularly interesting focus on mitochondrial function endothelial cells development aging onset diseases, including renal, cardio-metabolic, liver neurodegenerative ones. However, date, there no surveys which address above issues. To fill this gap, valuable collect recent findings about role mitochondria function, not only increase knowledge but also clinical applications. Here, we overview most issues view characterizing as an innovative potential target prevention aging, well treatment conditions.

Язык: Английский

---

Modification of MSCs with aHSCs-Targeting Peptide pPB for Enhanced Therapeutic Efficacy in Liver Fibrosis

Biomaterials, Год журнала: 2025, Номер unknown, С. 123295 - 123295

Опубликована: Март 1, 2025

Язык: Английский

---

Monitoring Ferroptosis with NIR Fluorescence Probe Capable of Reversible Mitochondria Nucleus Translocation

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Ferroptosis, a recently proposed form of regulated cell death, is characterized by surge in reactive oxygen species and subsequent depletion glutathione. The mitochondria nucleoli play pivotal roles the process ferroptosis. Therefore, monitoring interactions between during ferroptosis crucial for clarifying its physiological pathological processes. In this study, we designed synthesized near-infrared fluorescence probe MINU, which exhibits excellent stability against biological ions pH environments. Due to cationic structure good DNA affinity, MINU can target both nucleoli. Cell imaging demonstrates that reversibly migrate response changes mitochondrial membrane potential. By detecting localization intensity signals, effectively distinguish normal cell, apoptotic ferroptotic cell. Monitoring allows us more accurately appreciate processes

Язык: Английский

---

Neddylation and MASLD: From Pathophysiology to Therapy

Liver International, Год журнала: 2025, Номер 45(5)

Опубликована: Апрель 11, 2025

ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD), formerly known as non‐alcoholic fatty (NAFLD), is intimately linked to the dysregulation of key transcription factors or enzymes involved in hepatic metabolism. Neddylation, a post‐translational modification, refers covalent attachment neuronal precursor cell‐expressed developmentally down‐regulated 8 (Nedd8) specific substrates and plays significant role regulating protein conformation, localisation activity. The connection between neddylation MASLD burgeoning area research that presently focus extensive study. In this review, we on latest advancements regarding various critical pathological stages MASLD. We summarise both confirmed potential evidence neddylation's involvement onset progression Additionally, review biological basis neddylation, its correlation with propose directions for basic translational field. Finally, emphasise therapeutic applications targeting MASLD, particularly designing pharmacological inhibitors have broad effects

Язык: Английский

---

The role of mitochondria in iron overload-induced damage

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 25, 2024

Iron overload is a pathological condition characterized by the abnormal accumulation of iron within body, which may result from excessive intake, disorders metabolism, or specific disease states. This can lead to significant health complications and pose life-threatening risks. The induce cellular stress, adversely affecting structure function mitochondria, thereby compromising overall organ function. Given critical role mitochondria in metabolism homeostasis, it imperative investigate how mitochondrial dysfunction induced contributes progression, as well explore mitochondrial-related pathways potential therapeutic targets for various disorders. review examines mechanisms are implicated overload-induced damage, including increased oxidative DNA disruptions energy metabolism. Additionally, addresses relationship between these processes forms programmed cell death, alterations dynamics. Furthermore, discusses strategies aimed at alleviating mitigating associated with patients targeting pathways.

Язык: Английский

---

Mitochondrial oxidative stress and liver disease

Experimental and Clinical Gastroenterology, Год журнала: 2025, Номер 8, С. 143 - 157

Опубликована: Фев. 3, 2025

The liver is an important organ of metabolism and detoxification and, therefore, requires a large amount energy, which mainly produced by mitochondria. Mitochondrial oxidative stress, occurs when enzymatic non-enzymatic antioxidants are overloaded with reactive oxygen species (ROS) formed during various pathological processes. This leads to hepatocellular dysfunction eventually, fibrosis. review devoted modern concepts the pathophysiological foundations mitochondrial stress its effect on development chronic diseases etiologies.

Язык: Английский

---

Cortex Dictamni-induced hepatotoxicity by enhanced oxidative phosphorylation: insights from integrative transcriptomics, proteomics, and metabolomics analyses

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156511 - 156511

Опубликована: Фев. 1, 2025

Язык: Английский

---