Targeting cholesterol metabolism: a promising therapy strategy for cancer
Acta Pharmacologica Sinica,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Язык: Английский
The Role of Cholesterol Metabolism and Its Regulation in Tumor Development
Yongmei Wu,
Wenqian Song,
Su Min
и другие.
Cancer Medicine,
Год журнала:
2025,
Номер
14(7)
Опубликована: Март 27, 2025
ABSTRACT
Background
Within
the
tumor
microenvironment,
cells
undergo
metabolic
reprogramming
of
cholesterol
due
to
intrinsic
cellular
alterations
and
changes
in
extracellular
milieu.
Furthermore,
within
this
microenvironment
influences
immune
landscape
tumors,
facilitating
evasion
consequently
promoting
tumorigenesis.
These
biological
involve
modifications
numerous
enzymes
associated
with
uptake
synthesis,
including
NPC1L1,
SREBP,
HMGCR,
SQLE,
PCSK9.
Review
This
review
systematically
summarizes
role
metabolism
its
cancer
progression,
examines
mechanisms
through
which
dysregulation
affects
discusses
recent
advancements
therapies
that
target
metabolism.
Conclusion
Targeting
metabolism‐related
can
inhibit
growth,
reshape
landscapes,
rejuvenate
antitumor
immunity,
offering
potential
therapeutic
avenues
treatment.
Язык: Английский
Decoding Hepatocellular Carcinoma Metastasis: Molecular Mechanisms, Targeted Therapies, and Potential Biomarkers
Ke Wei,
Chunxiu Peng,
Yang Ou
и другие.
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(4), С. 263 - 263
Опубликована: Апрель 8, 2025
Hepatocellular
carcinoma
(HCC)
is
a
leading
cause
of
cancer-related
mortality
worldwide,
with
metastasis
representing
pivotal
factor
in
poor
prognosis
and
high
fatality
rates.
This
review
offers
comprehensive
examination
the
key
molecular
events
regulatory
mechanisms
driving
HCC
metastasis,
particular
focus
on
genetic
mutations,
epigenetic
alterations,
dysregulated
signaling
pathways.
Special
emphasis
placed
role
three-dimensional
genome
structural
remodeling
initiation
metastatic
progression.
Additionally,
latest
advances
targeted
therapies
for
advanced
are
summarized,
including
both
first-line
second-line
treatments,
highlighting
their
impact
controlling
disease.
The
also
examines
variety
potential
biomarkers
linked
to
circulating
tumor
cells,
DNA,
exosomal
contents,
all
which
demonstrate
significant
promise
early
detection,
diagnosis,
therapeutic
monitoring
metastasis.
By
bridging
insights
clinical
applications,
this
provides
valuable
perspectives
guide
future
research
diagnosis
treatment
Язык: Английский
Comprehensive analysis of the value of angiogenesis and stemness‐related genes in the prognosis and immunotherapy of ovarian cancer
BioFactors,
Год журнала:
2024,
Номер
51(1)
Опубликована: Дек. 20, 2024
Abstract
Tumor
angiogenesis
and
the
presence
of
cancer
stem
cells
(CSCs)
are
critical
characteristics
tumors.
Previous
research
has
demonstrated
that
promote
tumor
angiogenesis,
while
increased
vascularity,
in
turn,
fosters
growth
cells.
This
creates
a
detrimental
cycle
contributes
to
progression.
However,
studies
investigating
stemness
ovarian
(OV)
limited.
In
this
study,
we
employed
cluster
analysis
LASSO
methods
assess
significance
angiogenesis‐
stemness‐related
genes
efficacy
OV
immunotherapy.
Through
multivariate
Cox
regression
Friends
analysis,
identified
TNFSF11
as
most
significant
prognostic
gene
associated
with
stemness.
Additionally,
molecular
docking
results
confirmed
exhibits
high
affinity
for
sorafenib
sunitinib.
summary,
first
time,
conducted
comprehensive
roles
prognosis
immunotherapy
patients,
revealing
novel
therapeutic
target.
Язык: Английский