Comprehensive analysis of the value of angiogenesis and stemness‐related genes in the prognosis and immunotherapy of ovarian cancer DOI Creative Commons
Linsen Zhou, Yu Min, Qiqi Cao

et al.

BioFactors, Journal Year: 2024, Volume and Issue: 51(1)

Published: Dec. 20, 2024

Abstract Tumor angiogenesis and the presence of cancer stem cells (CSCs) are critical characteristics tumors. Previous research has demonstrated that promote tumor angiogenesis, while increased vascularity, in turn, fosters growth cells. This creates a detrimental cycle contributes to progression. However, studies investigating stemness ovarian (OV) limited. In this study, we employed cluster analysis LASSO methods assess significance angiogenesis‐ stemness‐related genes efficacy OV immunotherapy. Through multivariate Cox regression Friends analysis, identified TNFSF11 as most significant prognostic gene associated with stemness. Additionally, molecular docking results confirmed exhibits high affinity for sorafenib sunitinib. summary, first time, conducted comprehensive roles prognosis immunotherapy patients, revealing novel therapeutic target.

Language: Английский

Targeting cholesterol metabolism: a promising therapy strategy for cancer DOI

Chun-Lan Dai,

Zhixin Qiu, Anqi Wang

et al.

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
The Role of Cholesterol Metabolism and Its Regulation in Tumor Development DOI Creative Commons

Yongmei Wu,

Wenqian Song,

Su Min

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(7)

Published: March 27, 2025

ABSTRACT Background Within the tumor microenvironment, cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in extracellular milieu. Furthermore, within this microenvironment influences immune landscape tumors, facilitating evasion consequently promoting tumorigenesis. These biological involve modifications numerous enzymes associated with uptake synthesis, including NPC1L1, SREBP, HMGCR, SQLE, PCSK9. Review This review systematically summarizes role metabolism its cancer progression, examines mechanisms through which dysregulation affects discusses recent advancements therapies that target metabolism. Conclusion Targeting metabolism‐related can inhibit growth, reshape landscapes, rejuvenate antitumor immunity, offering potential therapeutic avenues treatment.

Language: Английский

Citations

0
Decoding Hepatocellular Carcinoma Metastasis: Molecular Mechanisms, Targeted Therapies, and Potential Biomarkers DOI Creative Commons
Ke Wei,

Chunxiu Peng,

Yang Ou

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 263 - 263

Published: April 8, 2025

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with metastasis representing pivotal factor in poor prognosis and high fatality rates. This review offers comprehensive examination the key molecular events regulatory mechanisms driving HCC metastasis, particular focus on genetic mutations, epigenetic alterations, dysregulated signaling pathways. Special emphasis placed role three-dimensional genome structural remodeling initiation metastatic progression. Additionally, latest advances targeted therapies for advanced are summarized, including both first-line second-line treatments, highlighting their impact controlling disease. The also examines variety potential biomarkers linked to circulating tumor cells, DNA, exosomal contents, all which demonstrate significant promise early detection, diagnosis, therapeutic monitoring metastasis. By bridging insights clinical applications, this provides valuable perspectives guide future research diagnosis treatment

Language: Английский

Citations

0
Comprehensive analysis of the value of angiogenesis and stemness‐related genes in the prognosis and immunotherapy of ovarian cancer DOI Creative Commons
Linsen Zhou, Yu Min, Qiqi Cao

et al.

BioFactors, Journal Year: 2024, Volume and Issue: 51(1)

Published: Dec. 20, 2024

Abstract Tumor angiogenesis and the presence of cancer stem cells (CSCs) are critical characteristics tumors. Previous research has demonstrated that promote tumor angiogenesis, while increased vascularity, in turn, fosters growth cells. This creates a detrimental cycle contributes to progression. However, studies investigating stemness ovarian (OV) limited. In this study, we employed cluster analysis LASSO methods assess significance angiogenesis‐ stemness‐related genes efficacy OV immunotherapy. Through multivariate Cox regression Friends analysis, identified TNFSF11 as most significant prognostic gene associated with stemness. Additionally, molecular docking results confirmed exhibits high affinity for sorafenib sunitinib. summary, first time, conducted comprehensive roles prognosis immunotherapy patients, revealing novel therapeutic target.

Language: Английский

Citations

2