Transtornos psiquiátricos no Covid longa: revisão integrativa da prevalência global

Revista Científica Multidisciplinar Núcleo do Conhecimento, Год журнала: 2025, Номер unknown, С. 05 - 24

Опубликована: Фев. 25, 2025

A pandemia de Covid-19 trouxe impactos relevantes e duradouros na saúde mental grande parte dos indivíduos que tiveram contato com o vírus SARS-CoV-2, especialmente aqueles manifestaram determinados sintomas após a infecção inicial, caracterizando síndrome pós-covid. Este estudo buscou realizar uma revisão integrativa da literatura para elucidar prevalência transtornos psiquiátricos associados ao Covid Longa, tais como ansiedade, depressão, transtorno estresse pós-traumático (TEPT) distúrbios do sono, bem determinar base nos estudos os principais fatores risco à COVID Longa. Para tanto, foram pesquisados artigos completos nas bases dados pesquisa Scientific Eletronic Library Online, Biblioteca Virtual em Saúde PubMed, publicados entre 2020 2024, idiomas inglês português. Após triagem, 19 incluídos. Destacam-se resultados: alta ansiedade sono TEPT. faixa etária pediátrica apresentou menores taxas sintomas, porém efeitos significativos no desenvolvimento socioemocional. Fatores determinantes indicam maior vulnerabilidade são: sexo feminino, idade avançada, comorbidades prévias, infecções graves internação Unidade Terapia Intensiva (UTI). Desse modo, conclui-se Longa são frequentes persistentes, apresentando implicações profundas global, evidencia necessidade estratégias multidisciplinares personalizadas reabilitação enfoque suporte psicológico.

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Long Covid oder psychisch krank?

MMW - Fortschritte der Medizin, Год журнала: 2025, Номер 167(5), С. 60 - 65

Опубликована: Март 1, 2025

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Emerging Viral Infections (ZIKV, SARS‐CoV‐2, and MPXV) and Depression: Ketamine and (S, R)‐Ketamine as Promising Antidepressants

Reviews in Medical Virology, Год журнала: 2025, Номер 35(3)

Опубликована: Апрель 9, 2025

ABSTRACT Emerging viral pathogens, newly reported or rapidly evolving viruses, are a significant public health concern worldwide. Beyond their characteristic clinical presentations, emerging such as monkeypox virus (MPXV) and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), have been increasingly implicated in the development of various neuropsychiatric complications including depression, mainly due to ability induce neuroinflammation, immune dysfunction, neurotransmitter imbalances. Depression is common mental condition characterised by continuous low mood sadness, pessimism, anxiety, even tendency suicide main symptoms. Post depression commonly shows challenges, traditional antidepressant agents exhibit suboptimal efficacy prolonged onset action. Regarding this, ketamine its enantiomers, S‐ketamine R‐ketamine, recently received increasing attention potential options light potent effective properties. The present review describes underlying pathophysiological mechanisms associated with highlighting role neuroinflammation disturbances inneurotransmitter systems. It also discusses current evidence demonstrating effectiveness safety, especially case treatment‐resistant growing relevance for linked infections, depression. Although preliminary reports propose effectiveness, additional studies needed optimal treatment strategies, long‐term incorporation into practice. Addressing these challenges will be critical optimising ketamine‐ (S, R)‐ketamine‐containing therapeutic protocols treating infections.

Язык: Английский

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Sex-Specific Inflammatory Profiles Affect Neuropsychiatric Issues in COVID-19 Survivors

Biomolecules, Год журнала: 2025, Номер 15(4), С. 600 - 600

Опубликована: Апрель 18, 2025

Post-COVID syndrome has unveiled intricate connections between inflammation, depressive psychopathology, and cognitive impairment. This study investigates these relationships in 101 COVID-19 survivors, focusing on sex-specific variations. Utilizing path modelling techniques, we analyzed the interplay of a one-month 48-biomarker inflammatory panel, with three-months symptoms performance. The findings indicate that impairment is influenced by both inflammation depression overall cohort. However, prominent differences emerged. In females, lingering imbalance pro- anti-inflammatory responses—likely reflecting long-lasting immune alterations triggered COVID-19—significantly affects functioning shows marginal, though not statistically significant, association symptoms. suggests mixed profile may contribute to outcomes. Conversely, males, was inversely associated severity, protective effects from regulatory mediators (IL-2, IL-4, IL-6, IL-15, LIF, TNF-α, β-NGF) against depression. appeared be driven mainly symptoms, minimal influence markers. These results highlight distinct pathways responses post-COVID-19, potentially shaped endocrine mechanisms. suggest persistent foster long-term neuropsychiatric sequelae, possibly through its brain, underscore need for sex-tailored therapeutic strategies address lasting impact COVID-19.

Язык: Английский

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Breaking free from the inflammatory trap of depression: Regulating the interplay between immune activation and plasticity to foster mental health

Neuroscience Applied, Год журнала: 2023, Номер 3, С. 103923 - 103923

Опубликована: Ноя. 8, 2023

Immune alterations have been widely implicated in the onset, progression, and treatment of major depressive disorder. However, our comprehension intricate link between immune function psychopathology remains fragmented limited. Here we propose that interplay neural plasticity is key transition from to mental wellbeing. In particular, any deviation toward an extreme activation or suppression leads a dysregulation molecular machinery underlying plasticity. Therefore, pro–inflammatory conditions depressed patients are associated with impaired plasticity, limiting potential recover. Patient's confinement within their pathological state here referred as inflammatory trap depression. The normalization reinstates thereby restoring capacity attain Since growing evidence showing reinstating does not lead improvement per se but increases likelihood recovery, combining activity environmental promoting wellbeing critical achieve beneficial outcome. This theoretical framework allows reconcile conceptual discrepancies immunopsychiatry such egg chicken nor sufficient necessary issues. Overall, tuning system promote promising approach refine develop innovative therapeutic strategies for depression, leading personalized highly effective treatments.

Язык: Английский

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Cognitive reserve, depressive symptoms, obesity, and change in employment status predict mental processing speed and executive function after COVID-19

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Янв. 29, 2024

Abstract The risk factors for post-COVID-19 cognitive impairment have been poorly described. This study aimed to identify the sociodemographic, clinical, and lifestyle characteristics that characterize a group of condition (PCC) participants with neuropsychological impairment. sample included 426 PCC who underwent neurobehavioral evaluation. We selected seven mental speed processing executive function variables obtain data-driven partition. Clustering algorithms were applied, including K-means, bisecting Gaussian mixture models. Different machine learning then used classifier able separate two clusters according demographic, emotional, variables, logistic regression least absolute shrinkage selection operator (LASSO) (L1) Ridge (L2) regularization, support vector machines (linear/quadratic/radial basis kernels), decision tree ensembles (random forest/gradient boosting trees). All clustering quality measures in agreement detecting only data based solely on performance. A model four (cognitive reserve, depressive symptoms, obesity, change work situation) obtained LASSO regularization was classify between good poor performers an accuracy weighted averaged precision 72%, recall 73%, area under curve 0.72. individuals lower more employment status at greater performance tasks requiring function. Study registration : www.ClinicalTrials.gov , identifier NCT05307575.

Язык: Английский

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Trajectory of anxiety/depressive symptoms and sleep quality in individuals who had been hospitalized by COVID-19: The LONG-COVID-EXP multicenter study

Journal of Psychosomatic Research, Год журнала: 2024, Номер 179, С. 111635 - 111635

Опубликована: Март 1, 2024

To apply Sankey plots and exponential bar for visualizing the evolution of anxiety/depressive symptoms poor sleep in previously hospitalized COVID-19 survivors. A sample 1266 subjects who were due to a SARS-CoV-2 from March–May 2020 assessed at 8.4 (T1), 13.2 (T2) 18.3 (T3) months after hospitalization. The Hospital Anxiety Depression Scale was used determine anxiety (HADS-A) depressive (HADS-D) symptoms. Pittsburgh Sleep Quality Index (PSQI) evaluated quality. Clinical features, onset hospital data collected medical records. revealed that prevalence symptomatology (HADS-A ≥ 8 points) 22.5% (n = 285) T1, 17.6% 223) T2, 7.9% 100) T3, whereas (HADS-D 14.6% 185) 10.9% 138) 6.1% 78) T3. Finally, (PSQI≥8 decreased 32.8% 415) 28.8% 365) 24.8% 314) recovery curves show decrease trend these recovered following years discharge. regression models did not reveal records associated with or sleep. use shows fluctuating during first infection. In addition, No risk factors identified this cohort.

Язык: Английский

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The Role of Diet and Specific Nutrients during the COVID-19 Pandemic: What Have We Learned over the Last Three Years?

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(7), С. 5400 - 5400

Опубликована: Апрель 4, 2023

Nutrients and diets have an important impact on our immune system infection risk a huge number of papers been published dealing with various aspects nutrition in relation to SARS-CoV-2 or COVID-19 severity. This narrative review aims give update this association tries summarize some the most findings after three years pandemic. The analysis major studies systematic reviews leads conclusion that healthy plant-based diet reduces risks for especially Regarding micronutrients, vitamin D is fore, but also zinc, C and, extent, selenium may play role COVID-19. Furthermore, omega-3-fatty acids their anti-inflammatory effects deserve attention. Therefore, aim societal nutritional efforts future should be foster high quality diet, which not only exerts beneficial non-communicable diseases such as type 2 diabetes obesity are primary factors worse outcomes. Another focus good supply critical immune-effective nutrients, zinc.

Язык: Английский

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Post-COVID Trajectory of Pentraxin 3 Plasma Levels Over 6 Months and Their Association with the Risk of Developing Post-Acute Depression and Anxiety

CNS Drugs, Год журнала: 2024, Номер 38(6), С. 459 - 472

Опубликована: Апрель 24, 2024

Язык: Английский

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Effects of Perceived COVID-19 Exposure and Action-Outcome Predictability on the Motivation to Invest Cognitive Effort

Zeitschrift für Neuropsychologie, Год журнала: 2024, Номер 35(2), С. 89 - 103

Опубликована: Май 1, 2024

Abstract: Everyday life situations characterized by poor controllability because of restrictions and uncertainty about action outcomes may attenuate motivational states executive control. This article explores the interaction a prior experience with COVID-19 susceptibility to respond challenging situation low action-outcome predictability. We assessed cognitive effort readiness as willingness invest in cognitively demanding tasks. Individuals history exhibited more pronounced reduction after experiencing experimentally induced unpredictability compared controls. These results suggest generalization perceived loss control among individuals history. findings contribute conceptualizing assessing long-term consequences pandemic-induced emotional problems.

Язык: Английский

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