Electrochemical multicomponent synthesis of 4-selanylpyrazoles under catalyst- and chemical-oxidant-free conditions

Green Chemistry, Год журнала: 2021, Номер 23(11), С. 3950 - 3954

Опубликована: Янв. 1, 2021

An electrochemical multicomponent reaction was established under catalyst-, chemical-oxidant-free and mild conditions, which provides an eco-friendly simple protocol for constructing 4-selanylpyrazoles from easily available raw materials with high yields.

Язык: Английский

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Visible-light-initiated tandem synthesis of difluoromethylated oxindoles in 2-MeTHF under additive-, metal catalyst-, external photosensitizer-free and mild conditions

Chinese Chemical Letters, Год журнала: 2021, Номер 32(6), С. 1907 - 1910

Опубликована: Янв. 18, 2021

Язык: Английский

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Carbon dioxide cycle via electrocatalysis: Electrochemical carboxylation of CO2 and decarboxylative functionalization of carboxylic acids

Green Synthesis and Catalysis, Год журнала: 2021, Номер 2(1), С. 19 - 26

Опубликована: Фев. 1, 2021

As one of the most important biogeochemical cycles, carbon dioxide (CO2) cycle between atmosphere and biosphere has a profound impact on life earth. Therefore, search for sustainable solutions to normalize currently unbalanced is central research topic many scientific disciplines. The green electrocatalysis offers very promising answer cycle. In this review, recent advances in enabled CO2 including electrochemical carboxylation decarboxylative functionalization carboxylic acids are highlighted.

Язык: Английский

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Transition-metal-free C–S bond cleavage and transformation of organosulfur compounds

Chemical Communications, Год журнала: 2023, Номер 59(36), С. 5343 - 5364

Опубликована: Янв. 1, 2023

The activation and transformation of organic chemical bonds is a fundamental scientific problem. In the past several decades, C-S bond cleavage for construction C-C C-heteroatom has received tremendous attention in chemistry. Although significant progress been made field transition metal strategies, variety novel transition-metal-free strategies have also developed using halogenated reagents, oxidants, acids, bases. Moreover, photochemical electrochemical methods to achieve organosulfur compounds. To date, however, no comprehensive review reported. Therefore, we herein provide major advances compounds, including thioethers, sulfoxides, sulfones, thioacetals, sulfonium salts, sulfur ylides.

Язык: Английский

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N‐Heterocyclic Carbene‐Catalyzed Atroposelective Annulation for Access to Thiazine Derivatives with C−N Axial Chirality

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(17), С. 9362 - 9367

Опубликована: Фев. 4, 2021

Abstract A catalytic atroposelective cycloaddition reaction between thioureas and ynals is developed. This features the first NHC‐catalyzed addition of to acetylenic acylazolium intermediates eventually set up C−N axial chirality with excellent optical purities. The obtained axially chiral thiazine derivative products bear multiple functional groups are feasible for further transformations.

Язык: Английский

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Sustainable electrochemical cross-dehydrogenative coupling of 4-quinolones and diorganyl diselenides

CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION), Год журнала: 2021, Номер 42(9), С. 1445 - 1450

Опубликована: Май 6, 2021

Язык: Английский

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Near-perfect control of the regioselective glucosylation enabled by rational design of glycosyltransferases

Green Synthesis and Catalysis, Год журнала: 2021, Номер 2(1), С. 45 - 53

Опубликована: Янв. 27, 2021

Regioselective syntheses of glycosides using modern chemical methods suffer from the need to invoke multiple steps protection and deprotection, even then product mixtures may occur. Discovering tuning by mutagenesis glycosyltransferases (GTs) with considerable substrate promiscuity is an alternative challenge. We tuned rational design based on extended Focused Rational Iterative Site-specific Mutagenesis (FRISM) a newly identified GT Siraitia grosvenorii (UGT74AC2) as catalyst in targeted regioselective glucosylation polyhydroxy silybin derivatives. A handful mutants was constructed restricted set rationally chosen amino acids, providing variants showing 94%, > 99% selectivity 3-OH, 7-OH 3,7-O-diglycoside, respectively, compared wildtype resulting 22%:39%:39% mixture. Remarkably, N- S-glucosylation achieved. Docking molecular dynamics (MD) simulations studies shed light origin regioselectivity. These findings can be invoked guide future enzymatic tailoring UGTs production flavonoids potent pharmaceuticals other useful compounds.

Язык: Английский

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Practical and sustainable approach for clean preparation of 5-organylselanyl uracils

Chinese Chemical Letters, Год журнала: 2020, Номер 32(1), С. 475 - 479

Опубликована: Сен. 23, 2020

Язык: Английский

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The application of clean production in organic synthesis

Chinese Chemical Letters, Год журнала: 2021, Номер 32(5), С. 1637 - 1644

Опубликована: Фев. 26, 2021

Язык: Английский

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Transition metal-catalyzed branch-selective hydroformylation of olefins in organic synthesis

Green Synthesis and Catalysis, Год журнала: 2021, Номер 2(3), С. 247 - 266

Опубликована: Май 7, 2021

Hydroformylation of olefins can generate linear and branched aldehydes, the aldehydes are attractive precursors for synthesis fine chemicals pharmaceuticals. is considered an important strategy green chemistry because its intrinsic atom economic nature recent development highly selective protocols. We herein summarize advances hydroformylation showing selectivity in organic synthesis. A mechanistic discussion provided prior to examples synthetically useful branch-selective reactions. Branch-selective further contribute construction chiral molecules design one-pot This review aims provide information about catalyst selection, reaction conditions, substrate scope hydroformylation, inspire this chemistry.

Язык: Английский

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