The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(7), С. 5200 - 5206
Опубликована: Март 19, 2024
A
regiodivergent
allylation
of
1H-indoles
highly
selectively
at
the
C3
and
N1
positions
with
β-acyl
allylic
sulfides
through
desulfurative
C–C/C–N
bond-forming
reactions
has
been
developed
under
mild
conditions.
Notably,
remarkable
site-selective
switch
can
be
achieved
by
a
delicate
choice
solvents
bases.
This
cost-efficient
method
displays
broad
substrate
scope,
good
functional
compatibility,
excellent
site-selectivity,
thus
offering
divergent
synthesis
indole
substituted
α-branched
enones,
which
possess
diverse
potential
opportunities
for
further
applications
derivatization.
RSC Advances,
Год журнала:
2025,
Номер
15(2), С. 1134 - 1151
Опубликована: Янв. 1, 2025
Due
to
the
presence
of
pyridyl
directing
group,
N-aryl-2-aminopyridines
can
quickly
form
stable
complexes
with
metals,
leading
cyclization
and
functionalization
reactions.
A
large
number
N-heterocycles
nitrogen-based
molecules
be
easily
constructed
via
this
direct
atom-economical
cross-coupling
strategy.
In
review,
we
have
highlighted
transformations
in
various
transition
metal
catalysts,
such
as
palladium,
rhodium,
iridium,
ruthenium,
cobalt
copper.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(11), С. 2587 - 2595
Опубликована: Апрель 19, 2024
Abstract
A
photochemical
synthesis
of
biologically
relevant
benzyl
oxindoles
is
presented
via
electron‐donor
acceptor
(EDA)
complex
strategy.
This
exogenous
photocatalyst‐free
method
describes
the
formation
a
new
electron
donor‐acceptor
based
on
potassium
carbonate
and
thianthrenium
salts
for
C(
sp
2
)−C(
3
)
bond
formation.
transition‐metal
free
reaction
allows
rapid
increase
in
molecular
complexity
chemical
space,
tolerating
different
functional
groups
as
well
sophisticated
biomolecules.
The
scalability
sustainability
this
highlighted
by
an
important
waste
recovery
protocol.
Mechanistic
investigations
support
EDA
that
induces
radical
chain,
applicability
showcased
straightforward
derivatization
reactions.
Journal of Heterocyclic Chemistry,
Год журнала:
2023,
Номер
61(1), С. 29 - 70
Опубликована: Окт. 26, 2023
Abstract
Sulfur
ylides
are
versatile
structures
that
display
various
characteristics
and
participate
in
a
myriad
of
reactions
to
produce
simple,
effective,
sometimes
stereoselective
toward
synthesizing
sulfur‐containing
compounds.
Nonetheless,
their
fulfillment
tremendous
developments
have
been
made
this
field
the
past
few
decades.
In
comprehensive
review,
luminosity
is
illuminated
on
application
sulfur
involved
domino,
cascade
annulation
reactions,
carbene
trapping
reagents
with
chameleonic
reactivity.
numerous
decennary,
chemists
used
solvent‐dependent,
rhodium
catalyzed,
dealkylative
intercepted,
photochemical
reaction,
halotrifluoromethylation,
benzannulation,
amidation
name
such
as
Mizoroki–Heck,
Suzuki–Miyaura,
Sommelet–Hauser
rearrangements.
Moreover,
other
prime
applications
include
metal
catalysis,
epoxidation
carbonyl
compounds,
acylmethylation,
cyclomerization,
oxidation,
insertion
reactions.
Additionally,
some
extremely
useful
play
major
role
synthesis
medicinally
active
heterocycles
structural
motifs.
This
review
article
discusses
all
these
proposed
mechanisms,
current
scenario,
at
length.
tutorial
concludes
by
providing
future
outlook
investigation
into
compounds
synthesized
using
it
great
potential
be
industries,
laboratories,
pharmaceutical
companies,
drug
production,
clinical
use,
medicinal
chemistry,
agrochemical
purposes.
Abstract
In
this
report,
we
have
synthesized
two
new
NCS
pincer
ligands
by
the
Schiff
base
reaction
of
3‐((phenylthio)methoxy)benzaldehyde
(
P
)
with
alkyl
amines
t
butylamine
L1
and
1‐adamantylamine
L2
)).
The
palladium
complexes
butylamine=
C1
1‐adamantylamine=
C2
these
were
their
PdCl
2
(CH
3
CN)
precursor.
newly
characterized
using
various
analytical
spectroscopic
techniques
such
as
1
H,
13
C{
H}
Nuclear
Magnetic
Resonance
(NMR),
Ultraviolet–visible
(UV‐Visible),
Fourier
Transform
Infrared
(FTIR)
Spectroscopy,
High‐Resolution
Mass
Spectrometry
(HRMS).
structure
ligand
its
coordination
mode
precursor
studied
help
single‐crystal
X‐ray
diffraction.
showed
distorted
square
planar
geometry
around
center.
used
catalysts
for
regioselective
cross‐dehydrogenative
alkenation
2‐arylthiophene
derivatives.
complex
,
where
sterically
bulky
adamantyl
is
part
side
arm
a
higher
yield
reaction.
Only
2.5
mol%
catalyst
loading
was
sufficient
to
achieve
74–95
%
yields
desired
products
excellent
functional
group
tolerance
under
mild
conditions.
poisoning
experiments
(PPh
Hg)
homogeneous
nature
catalytic
process.
plausible
mechanism
proposed
based
on
control
time‐dependent
HRMS
studies.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
summarizes
recent
progress
in
EDA
complex-promoted
C–S
bond
formation
using
various
sulfur-containing
substrates
under
mild
conditions
via
visible
light
irradiation.
The Chemical Record,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
Abstract
Selectfluor,
[1‐chloromethyl‐4‐fluoro‐1,4‐diazoniabicyclo[2.2.2]octane
bis(tetrafluoroborate)],
is
a
highly
valuable
reagent
in
contemporary
chemistry,
serving
not
only
as
an
electrophilic
fluorinating
agent
but
also
effective
catalyst
the
synthesis
of
various
pharmaceutically
relevant
heterocycles.
This
review
article
seeks
to
present
comprehensive
overview
significant
heterocyclic
ring
formations
facilitated
by
selectfluor.
Both
metal‐free
and
metal‐catalyzed
recent
advancement
on
selectfluor
mediated
cyclisation
processes
are
discussed
this
mainly
over
last
eight
years
(2017‐April
2024).
