A critical review on the dissemination of PH and stimuli-responsive polymeric nanoparticular systems to improve drug delivery in cancer therapy

Critical Reviews in Oncology/Hematology, Год журнала: 2023, Номер 185, С. 103961 - 103961

Опубликована: Март 13, 2023

Язык: Английский

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The Pivotal Role of Preclinical Animal Models in Anti-Cancer Drug Discovery and Personalized Cancer Therapy Strategies

Pharmaceuticals, Год журнала: 2024, Номер 17(8), С. 1048 - 1048

Опубликована: Авг. 9, 2024

The establishment and utilization of preclinical animal models constitute a pivotal aspect across all facets cancer research, indispensably contributing to the comprehension disease initiation progression mechanisms, as well facilitating development innovative anti-cancer therapeutic approaches. These have emerged crucial bridges between basic clinical offering multifaceted support investigations. This study initially focuses on importance benefits establishing models, discussing different types recent advancements in research. It then delves into treatment, studying characteristics stages tumor drugs. By integrating hallmarks we elaborate path drug provide guidance personalized therapy strategies, including synthetic lethality approaches novel drugs widely adopted field. Ultimately, summarize strategic framework for selecting safety experiments, tailored experimental modalities species, present an outlook prospects challenges associated with models. undoubtedly offer new avenues encompassing protocols. Nevertheless, road ahead continues be lengthy fraught obstacles. Hence, encourage researchers persist harnessing advanced technologies refine thereby empowering these emerging paradigms positively impact patient outcomes.

Язык: Английский

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Effects of triggers of senescence and senolysis in murine pancreatic cancer cells

Hepatobiliary & pancreatic diseases international, Год журнала: 2024, Номер 23(6), С. 628 - 637

Опубликована: Июнь 4, 2024

Язык: Английский

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Mitochondrial uncoupling protein 2: a central player in pancreatic disease pathophysiology

Molecular Medicine, Год журнала: 2024, Номер 30(1)

Опубликована: Дек. 20, 2024

Язык: Английский

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