ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(12), С. 14605 - 14625
Опубликована: Март 15, 2024
In
the
face
of
severe
side
effects
systemic
chemotherapy
used
in
cervical
cancer,
topical
selective
drug
carriers
with
long-lasting
are
being
sought.
Hydrogels
suitable
platforms,
but
their
use
is
problematic
case
delivery
hydrophobic
drugs
anticancer
activity.
Herein,
hydrogels
constructed
unimolecular
micelles
displaying
enhanced
solubilization
aromatic
lipophilic
bioactive
compounds
presented.
Star-shaped
poly(benzyl
glycidyl
ether)-block-poly(glycidyl
glycerol
ether)
an
aryl-enriched
core
show
high
encapsulation
capacity
poor
water-soluble
nifuratel
and
clotrimazole.
Nifuratel
attained
selectivity
against
cancer
cells,
whereas
clotrimazole
preserved
its
original
selectivity.
The
combination
loaded
both
provided
synergism;
however,
they
were
still
cells.
cross-linking
drug-loaded
via
dynamic
boronic
esters
injectable
self-healable
hydrogel
also
synergistic
activity,
for
intravaginal
administration
assuring
effective
coverage
afflicted
tissue
area
efficient
permeability
compounds.
Here,
we
that
star-shaped
polyether
amphiphiles
ester
chemistry
provides
a
new
strategy
obtaining
platforms
delivery.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(13), С. 10858 - 10858
Опубликована: Июнь 29, 2023
Hepatocellular
carcinoma
(HCC)
is
the
most
common
primary
liver
tumor
and
often
diagnosed
at
an
unresectable
advanced
stage.
Systemic
chemotherapy
as
well
transarterial
chemoembolization
(TACE)
hepatic
arterial
infusion
(HAIC)
are
used
to
treat
HCC.
TACE
HAIC
have
long
been
standard
of
care
for
patients
with
HCC
but
limited
treatment
intrahepatic
lesions.
doxorubicin
or
chemohormonal
therapy
tamoxifen
also
considered,
neither
has
demonstrated
survival
benefits.
In
HCC,
cisplatin
administered
transhepatic
arterially
local
treatment.
Subsequently,
cisplatin-refractory
cases
due
drug
resistance,
a
shift
systemic
different
mechanism
action
expected
produce
new
antitumor
effects.
Cisplatin
tumors
other
than
This
review
summarizes
resistance
describes
major
hepatobiliary
cancers
which
anticancer
agent,
focus
on
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 8, 2024
Lactic
acid
was
formerly
regarded
as
a
byproduct
of
metabolism.
However,
extensive
investigations
into
the
intricacies
cancer
development
have
revealed
its
significant
contributions
to
tumor
growth,
migration,
and
invasion.
Post-translational
modifications
involving
lactate
been
widely
observed
in
histone
non-histone
proteins,
these
play
crucial
role
regulating
gene
expression
by
covalently
attaching
lactoyl
groups
lysine
residues
proteins.
This
discovery
has
greatly
enhanced
our
comprehension
lactic
acid's
involvement
disease
pathogenesis.
In
this
article,
we
provide
comprehensive
review
intricate
relationship
between
immunity,
occurrence
lactylation
malignant
tumors,
exploitation
targeted
lactate-lactylation
immunotherapy.
Additionally,
discuss
future
research
directions,
aiming
offer
novel
insights
that
could
inform
investigation,
diagnosis,
treatment
related
diseases.
Life Sciences,
Год журнала:
2024,
Номер
349, С. 122720 - 122720
Опубликована: Май 16, 2024
This
review
investigates
the
role
of
ferroptosis
in
combating
chemotherapy
resistance
ovarian
cancer,
with
a
focus
on
its
underlying
mechanisms
and
therapeutic
implications.
Antioxidants,
Год журнала:
2025,
Номер
14(2), С. 141 - 141
Опубликована: Янв. 24, 2025
Hepatocellular
carcinoma
(HCC)
is
the
third
most
common
cancer
in
terms
of
mortality
and
sixth
incidence
worldwide.
Treatment
varies
by
tumor
stage,
but
low
survival
rates
are
across
all
stages.
Due
to
these
poor
outcomes,
there
a
critical
need
for
new
treatment
options
lead
compounds,
prompting
an
active
search.
Geopropolis
has
been
identified
as
source
bioactive
compounds
with
various
pharmacological
activities,
including
anticancer
effects
against
different
types
cancer.
Since
stingless
bees
may
be
selective
native
botanical
species,
geopropolis
they
produce
can
have
unusual
chemical
profile.
In
this
study,
we
report
antioxidant
properties
potential
extracts
produced
Melipona
bicolor,
M.
marginata,
mondury
using
2D-
3D-
cell
culture
models.
The
profile
samples
UPLC-QTOF
HRMS/MS
indicated
ferreirin
dihydrokaempferide
main
flavonoids,
along
cupressic
acid
15-acetoxyisocupressic
abundant
diterpenoids.
Interestingly,
artepillin
C,
component
green
propolis,
was
also
detected.
showed
good
viability
inhibition
selectivity
indices
comparison
cisplatin
used
HCC
option.
capacity
high
correlated
cytotoxic
effect
cells.
Investigations
into
mechanisms
show
ability
induce
apoptosis
suppress
clonogenic
lines.
We
observed
spheroid
formation,
viability,
morphology
alterations.
This
first
time
described
panel
PLoS ONE,
Год журнала:
2025,
Номер
20(3), С. e0318740 - e0318740
Опубликована: Март 10, 2025
Ovarian
cancer
therapy
remains
a
challenge
for
human
health,
partly
due
to
chemotherapy
resistance.
Understanding
the
molecular
mechanisms
underlying
this
resistance
is
crucial.
Therefore,
identify
genes
involved
in
cisplatin
ovarian
cancer,
RNA-seq
analysis
of
A2780cp
(cisplatin-resistant)
and
A2780
(cisplatin-sensitive)
cell
lines
was
performed,
revealing
1-acylglycerol-3-phosphate
O-acyltransferase
3
(
AGPAT3
)
as
differentially
expressed
candidate
gene.
First,
MTT
confirmed
drug
sensitivity
lines.
Subsequent
reverse
transcription
quantitative
polymerase
chain
reaction
(RT-qPCR)
western
blotting
analyses
revealed
elevated
mTOR
expression
cells
compared
with
cells.
Additionally,
showed
increased
p-mTOR
(phospho-mTOR)/mTOR
p-S6K
(phospho-S6K)/S6K
ratios
The
overexpression
led
p-mTOR/mTOR
p-S6K/S6K
IC50
values,
shown
by
RT-qPCR,
blotting,
analysis.
Conversely,
shRNA-mediated
downregulation
resulted
reduced
ratios.
At
cellular
level,
survival
rates,
decreased
apoptosis,
caused
G2/M
cycle
arrest
under
treatment,
detected
apoptosis
assay,
flow
cytometry
Overall,
we
conclude
that
propose
targeting
gene
or
its
enzymatic
product
could
help
overcome
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101707 - 101707
Опубликована: Март 1, 2025
Cancer
stemness,
characterized
by
the
self-renewal
and
differentiation
capabilities
of
cancer
stem
cells
(CSCs),
is
a
critical
determinant
colorectal
(CRC)
chemo-immunotherapy.
Herein,
we
repurposed
copper-coordination
driven
metal-organic
nano-frameworks
(Cu-MOFs)
to
address
chemo-immunotherapy
resistance
posed
stemness.
These
Cu-MOFs
were
loaded
with
chemotherapeutic
agent
cisplatin
(CDDP),
resulting
in
formation
Cu-MOF@CDDP.
The
Cu-MOF@CDDP
are
efficiently
internalized
CRC
via
nanoparticle
mediated
endocytosis,
where
they
release
free
copper
ions
(Cu2+)
CDDP
high-glutathione
(GSH)
environment.
After
that,
forms
DNA-CDDP
adducts
that
inhibit
DNA
synthesis
repair,
while
Cu2+
induces
cuproptosis
disrupting
mitochondrial
metabolism.
Moreover,
fragments
originating
from
both
nucleus
mitochondria
activate
cGAS-STING
pathway,
thereby
initiating
anti-tumor
immune
responses.
Meanwhile,
depletes
intracellular
GSH
cuproptosis,
leading
downregulation
stemness-related
proteins
such
as
ZEB1
c-MYC,
which
enhances
efficacy
targeting
pathways
involved
maintaining
Consequently,
our
results
underscore
substantial
promise
overcoming
stemness-driven
therapeutic
resistance,
offering
transformative
approach
sensitize
