Tissue and Cell, Год журнала: 2024, Номер 93, С. 102699 - 102699
Опубликована: Дек. 24, 2024
Язык: Английский
Biomarker Research, Год журнала: 2024, Номер 12(1)
Опубликована: Март 21, 2024
Mesenchymal stromal/stem cells (MSCs) are used in many studies due to their therapeutic potential, including differentiative ability and immunomodulatory properties. These perform functions by using various mechanisms, such as the production of anti-inflammatory cytokines, growth factors, direct cell-to-cell contact, extracellular vesicles (EVs) production, mitochondrial transfer. However, mechanisms related immune checkpoints (ICPs) effect on MSCs less discussed. The main function ICPs is prevent initiation unwanted responses regulate system maintain homeostasis these responses. produced types regulatory cells, defects expression may be associated with excessive that can ultimately lead autoimmunity. Also, expressing different ligands (ICPLs), tumor formation durability responses, which leads tumors' escape. ICPLs affect cell both through secretion into microenvironment or interaction. Pre-treatment inflammatory conditions an increase potential. In addition environments have cytokines MSCs, they ICPLs. this review, we discuss expressed
Язык: Английский
Процитировано
13
Pharmaceutics, Год журнала: 2023, Номер 15(9), С. 2276 - 2276
Опубликована: Сен. 4, 2023
Inflammatory diseases are common pathological processes caused by various acute and chronic factors, some of them autoimmune diseases. Exosomes fundamental extracellular vesicles secreted almost all cells, which contain a series constituents, i.e., cytoskeletal cytosolic proteins (actin, tubulin, histones), nucleic acids (mRNA, miRNA, DNA), lipids (diacylglycerophosphates, cholesterol, sphingomyelin, ceramide), other bioactive components (cytokines, signal transduction proteins, enzymes, antigen presentation membrane transport/fusion molecules, adhesion molecules). This review will be synopsis the knowledge on contribution exosomes from different cell sources as possible therapeutic agents against inflammation, focusing several inflammatory diseases, neurological rheumatoid arthritis osteoarthritis, intestinal bowel disease, asthma, liver kidney injuries. Current indicates that role in therapy inflammation could distinctive. The main limitations to their clinical translation still production, isolation, storage. Additionally, there is an urgent need personalize treatments terms selection exosomes; dosages routes administration; deeper about biodistribution, type incidence adverse events, long-term effects exosomes. In conclusion, can very promising next-generation option, superior synthetic nanocarriers therapy, represent new strategy effective, safe, versatile, selective delivery systems future.
Язык: Английский
Процитировано
11
Pathology - Research and Practice, Год журнала: 2024, Номер 259, С. 155388 - 155388
Опубликована: Июнь 5, 2024
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Ноя. 3, 2023
Malignancies contain a relatively small number of Mesenchymal stem/stromal cells (MSCs), constituting crucial tumor microenvironment (TME) component. These comprise approximately 0.01–5% the total TME cell population. MSC differentiation potential and their interaction with environment enable these to affect cells’ growth, immune evasion, metastasis, drug resistance, angiogenesis. This type MSC, known as cancer-associated mesenchymal (CA-MSCs (interacts tumor/non-tumor in affects function by producing cytokines, chemokines, various growth factors facilitate migration, survival, proliferation, progression. Considering that effect different on each other is multi-faceted relationship, it essential discover role relationships for targeting therapy. Due immunomodulatory tissue repair characteristic MSCs, can help from aspects. CA-MSCs indirectly suppress antitumor response through several mechanisms, including decreasing dendritic (DCs) antigen presentation potential, disrupting natural killer (NK) differentiation, inducing immunoinhibitory subsets like tumor-associated macrophages (TAMs) Treg cells, checkpoint expression reduce effector T responses. Therefore, if be targeted treatment so population decreases, we hope improvement conditions. Also, studies show vital aspects tumor, angiogenesis, invasion metastasis. In this review article, will discuss detail some mechanisms which innate adaptive systems related
Язык: Английский
Процитировано
9
International Journal of Pharmaceutics, Год журнала: 2023, Номер 647, С. 123551 - 123551
Опубликована: Окт. 24, 2023
Язык: Английский
Процитировано
5
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 8, 2024
Due to the vital importance of lungs, lung-related diseases and their control are very important. Severe inflammatory responses mediated by immune cells were among leading causes lung tissue pathology damage during COVID-19 pandemic. In addition, uncontrolled cell can lead in other infectious non-infectious diseases. It is essential a way that leads homeostasis. Immunosuppressive drugs only suppress do not affect homeostasis reactions. The therapeutic application mesenchymal stem (MSCs), addition restoring homeostasis, promote regeneration through production growth factors differentiation into cells. However, communication between MSCs after treatment pulmonary essential, investigating this help develop clinical perspective. Different studies phase showed reverse fibrosis, increase regeneration, airway remodeling, reduce tissue. proliferation potential one mechanisms effects. Furthermore, they secrete exosomes function change function. Another important mechanism harmful with innate adaptive cells, which shift system toward regulatory hemostatic responses.
Язык: Английский
Процитировано
0
Tissue and Cell, Год журнала: 2024, Номер 93, С. 102699 - 102699
Опубликована: Дек. 24, 2024
Язык: Английский
Процитировано
0