Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil
Food Reviews International,
Год журнала:
2025,
Номер
unknown, С. 1 - 50
Опубликована: Янв. 4, 2025
Cancer
is
the
world's
second
most
common
cause
of
death,
with
colon
cancer
(CC)
ranking
third
in
prevalence
and
cancer-related
fatalities.
CC
originates
or
rectum
influenced
by
genetic
mutations,
lifestyle,
diet.
Although
chemotherapy,
especially
5-fluorouracil
(5-FU),
fundamental
to
treatment
has
improved
patient
survival,
its
benefits
are
often
limited
significant
side
effects
emerging
drug
resistance.
Recently,
plant-based
foods
have
drawn
interest
research
for
their
natural
bioactive
compounds
relatively
low
toxicity.
Certain
plant
not
only
exhibit
anti-cancer
activity
but
may
also
boost
effectiveness
5-FU
while
reducing
adverse
effects.
Despite
evidence
suggesting
a
synergistic
effect
between
5-FU,
this
area
remains
fragmented.
This
review
consolidates
current
on
including
fruits,
vegetables,
legumes,
tea
bioactives
treatment.
Besides,
it
explores
mechanisms
through
which
these
enhance
efficacy
reduce
effects,
evaluates
clinical
application
prospects,
identifies
challenges
future
directions.
comprehensive
analysis
aims
provide
scientific
foundation
integrated
CC,
highlighting
potential
enhancing
chemotherapy
associated
toxicities.
Язык: Английский
The Pharmaceutical and Pharmacological Potential Applications of Bilosomes as Nanocarriers for Drug Delivery
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1181 - 1181
Опубликована: Март 6, 2025
Nano-drug
delivery
systems
provide
targeted
solutions
for
addressing
various
drug
challenges,
leveraging
nanotechnology
to
enhance
solubility
and
permeability.
Liposomes,
explored
several
decades,
face
hurdles,
especially
in
oral
delivery.
Bile-acid
stabilized
vesicles
(bilosomes)
are
flexible
lipid
vesicles,
composed
of
phospholipids
or
other
surfactants,
along
with
amphiphilic
bile
salts,
they
show
superior
stability
pharmacokinetic
behavior
comparison
conventional
vesicular
(liposomes
niosomes).
Bilosomes
skin
penetration,
fluidize
the
stratum
corneum,
improve
stability.
In
applications,
bilosomes
overcome
drawbacks,
offering
improved
bioavailability,
controlled
release,
reduced
side
effects.
Vaccines
using
demonstrate
efficacy,
intranasal,
inhalation,
ocular,
buccal
applications
delivery,
targeted,
efficient,
activities.
Formulations
vary
based
on
active
substances
optimization
techniques,
showcasing
versatility
potential
across
diverse
routes.
Therefore,
aim
this
comprehensive
review
was
critically
explore
state-of-the-art
therapeutic
applications.
Язык: Английский
Inhibition of α-amylase activity by quercetin via multi-spectroscopic and molecular docking approaches
Food Bioscience,
Год журнала:
2024,
Номер
61, С. 104951 - 104951
Опубликована: Авг. 17, 2024
Язык: Английский
Bile salts: unlocking the potential as bio-surfactant for enhanced drug absorption
Pidugu Shivaji Ashok Chakravarthy,
Pankaj Popli,
Ranadheer Reddy Challa
и другие.
Journal of Nanoparticle Research,
Год журнала:
2024,
Номер
26(4)
Опубликована: Апрель 1, 2024
Язык: Английский
Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy
Russian Chemical Reviews,
Год журнала:
2024,
Номер
93(11), С. RCR5150 - RCR5150
Опубликована: Окт. 30, 2024
Diabetes
and
its
complications
derived
are
among
serious
global
health
concerns
that
critically
deteriorate
the
quality
of
life
patients
and,
in
some
cases,
result
lethal
outcome.
Herein,
general
information
on
pathogenesis,
factors
aggravating
course
disease
drugs
used
for
treatment
two
types
diabetes
briefly
discussed.
The
aim
review
is
to
introduce
supramolecular
strategies
currently
being
developed
mellitus
present
a
very
effective
alternative
chemical
synthesis,
allowing
fabrication
nanocontainers
with
switchable
characteristics
meet
criteria
green
chemistry.
Particular
attention
paid
organic
(amphiphilic
polymeric)
formulations,
including
those
natural
origin,
due
their
biocompatibility,
low
toxicity,
bioavailability.
advantages
limitations
different
nanosystems
discussed,
emphasis
adaptivity
noninvasive
administration
routes.<br>The
bibliography
includes
378
references.
Язык: Английский