Critical Reviews in Therapeutic Drug Carrier Systems,
Год журнала:
2024,
Номер
42(1), С. 1 - 54
Опубликована: Сен. 26, 2024
Phytopharmaceuticals
are
the
newly
termed
herbal
medicine,
which
includes
standardized
extract,
bioactive
fraction,
and
phytoconstituent.
They
have
been
practiced
to
cure,
treat,
mitigate
diseases.
many
health
benefits,
but
their
therapeutic
efficacy
is
limited
due
poor
absorption,
low
bioavailability,
early
elimination
profile.
A
novel
phospholipid
complex
a
introduced
patented
technology
developed
incorporate
plant
extracts/fractions
or
water-soluble
phytoconstituents
into
phospholipids
produce
lipid
compatible
molecular
complex,
called
phytosome,
improves
absorption
bioavailability.
In
formulations,
phytosome
most
advanced
dosage
form
that
has
an
upgraded
rate
enhanced
pharmacokinetics
compared
with
conventional
products.
The
results
from
hydrogen
bonding
between
phytoconstituents,
offering
maximum
incorporation
of
active
ingredients
lipidic
layer
core.
increased
formation
amphiphilic
phospholipid-complex
medicine.
This
review
highlights
role
on
delivery
bioactives
natural
extracts
particular
emphasis
phytosomes.
Moreover,
status
bioavailabilities,
commercial
products,
patents,
clinical
trials
phytosomal
systems
phytopharmaceuticals
were
addressed.
Biologics,
Год журнала:
2024,
Номер
Volume 18, С. 229 - 255
Опубликована: Сен. 1, 2024
Natural
products
have
proven
to
be
promising
anti-cancer
agents
due
their
diverse
chemical
structures
and
bioactivity.This
review
examines
central
role
in
cancer
treatment,
focusing
on
mechanisms
of
action
therapeutic
benefits.Medicinal
plants
contain
bioactive
compounds,
such
as
flavonoids,
alkaloids,
terpenoids
polyphenols,
which
exhibit
various
anticancer
properties.These
compounds
induce
apoptosis,
inhibit
cell
proliferation
cycle
progression,
interfere
with
microtubule
formation,
act
topoisomerase
targets,
angiogenesis,
modulate
key
signaling
pathways,
improve
the
tumor
microenvironment,
reverse
drug
resistance
activate
immune
cells.Herbal
drugs
offer
advantages,
particularly
selective
toxicity
against
cells,
reducing
adverse
side
effects
associated
conventional
chemotherapy.Recent
studies
clinical
trials
highlight
benefits
herbal
medicines
alleviating
effects,
improving
tolerance
chemotherapy
occurrence
synergistic
treatments.For
example,
medicine
SH003
was
found
safe
potentially
effective
treatment
solid
cancers,
while
Fucoidan
showed
anti-inflammatory
properties
that
are
beneficial
for
patients
advanced
cancer.The
current
research
landscape
is
extensive.Numerous
investigating
efficacy,
safety
cancers
lung,
prostate,
breast
hepatocellular
carcinoma.Promising
developments
include
polypharmacological
approach,
combination
therapies,
immunomodulation
improvement
quality
life.However,
there
still
challenges
development
use
natural
drugs,
need
further
into
action,
possible
interactions
optimal
dosage.Standardizing
extracts,
bioavailability
delivery,
overcoming
regulatory
acceptance
hurdles
critical
issues
addressed.Nonetheless,
warrant
investigation
development.Multidisciplinary
collaboration
essential
advance
therapy
integrate
these
mainstream
treatment.
Journal of Microencapsulation,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Фев. 24, 2025
In
this
study,
antineoplastic
effects
of
a
novel
soy
lecithin-based
phytosome
drug
delivery
system
containing
Barleria
lupulina
Lindl.
extract
(BLSP)
was
evaluated.
BLSP
prepared
using
the
thin-film
hydration
method
and
analysed
energy-dispersive
X-ray
spectroscopy,
scanning
electron
microscopy,
diffraction,
Zetasizer
technique.
Phytosomes
showed
mean-diameter
135
±
0.29
nm,
zeta
potential
−56
1.16
mV,
entrapment
efficiency
57.24
0.12%.
The
release
profiles
exhibited
two-phase
pattern
with
protracted
sustained
after
first
release.
had
cytotoxic
against
MCF-7
breast
HeLa
cervical
cancers
demonstrated
concentration-dependent
reduction
reactive
oxygen
species
mitochondrial
membrane
potential.
caused
upregulation
B-cell
lymphoma-2-associated-X
protein,
caspase-8,
caspase-9,
cluster
differentiation-95,
downregulation
lymphoma-2.
in
vivo
toxicity
study
safety
BLSP.
Overall,
has
as
promising
formulation
for
delivering
B.
phytoconstituents
to
treat
cancer.
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
ABSTRACT
A
complete
investigation
into
phytosome‐based
formulations
and
innovative
nanotechnology
is
presented
in
this
review.
This
aims
to
improve
the
bioavailability
therapeutic
effectiveness
of
herbal
components.
Phytosomes
can
significantly
increase
solubility,
absorption,
stability
compared
standard
by
encapsulating
active
phytoconstituents
phospholipid
complexes.
unique
ability
phytosomes
overcome
limits
traditional
a
potential
game
changer
medicine.
study
highlights
different
uses
across
various
health
disorders,
such
as
neurodegenerative
illnesses,
inflammatory
conditions,
diabetes,
cardiovascular
diseases,
wound
healing.
The
review
also
discusses
treating
infectious
diseases
improving
delivery
bioactive
compounds
that
have
improved
anticancer
efficacy
antibacterial
properties.
Despite
emergence
numerous
groundbreaking
discoveries,
substantial
barriers
remain
hinder
their
widespread
application.
Challenges
must
be
addressed
include
stability,
large‐scale
manufacture,
regulatory
hurdles,
limited
clinical
translation.
examines
limitations
present
practice,
mainly
focusing
on
variability
bioavailability.
crucial
need
for
future
research
phytosomes,
engaging
researchers
emphasizing
continuous
evolution
promising
area
Lipid-based
Nanoparticles
(LBNPs)
have
emerged
as
a
transformative
approach
in
cancer
treatment,
offering
innovative
drug
delivery
solutions
that
enhance
therapeutic
efficacy
while
minimizing
adverse
effects.
By
exploring
the
characterization,
classification,
synthesis,
targeting
strategies,
and
advantages
of
LBNPs,
this
study
highlights
how
LBNPs
been
used
to
overcome
limitations
traditional
chemotherapy
improve
patient
outcomes.
As
nanotechnology
revolutionizes
therapy,
emergence
promising
strategy
for
targeted
has
led
optimism
regarding
future
treatment.
This
review
extensively
assesses
structure,
categories,
production
methods,
benefits,
recent
advancements
treating
cancer.
It
also
current
challenges
possible
directions.
is
aimed
at
providing
comprehensive
understanding
LBNPs’
potential
therapy.
Liposomes,
nanostructured
lipid
carriers,
solid
nanoparticles,
lipid-polymer
hybrid
nanoparticles
are
all
types
each
with
unique
features
interest
These
particles
can
be
synthesized
through
various
procedures,
such
bulk
nanoprecipitation,
solvent-based
emulsification,
or
microfluidics.
Passive
systems,
active
responsive
platforms
direct
tumors.
Consequently,
provide
an
improved
release
pattern
minimizes
side
effects
enhancing
efficacy.
With
combination
offer
hopeful
Continued
research
expected
outcomes
overall
quality
life
care.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4162 - 4162
Опубликована: Апрель 9, 2024
Metabolic
disorders
(MDs),
including
dyslipidemia,
non-alcoholic
fatty
liver
disease,
diabetes
mellitus,
obesity
and
cardiovascular
diseases
are
a
significant
threat
to
human
health,
despite
the
many
therapies
developed
for
their
treatment.
Different
classes
of
bioactive
compounds,
such
as
polyphenols,
flavonoids,
alkaloids,
triterpenes
have
shown
therapeutic
potential
in
ameliorating
various
disorders.
Most
these
compounds
present
low
bioavailability
when
administered
orally,
being
rapidly
metabolized
digestive
tract
which
makes
metabolites
less
effective.
Moreover,
some
cannot
fully
exert
beneficial
properties
due
solubility
complex
chemical
structure
impede
passive
diffusion
through
intestinal
cell
membranes.
To
overcome
limitations,
an
innovative
delivery
system
phytosomes
was
developed.
This
review
aims
highlight
scientific
evidence
proving
enhanced
benefits
formulated
compared
free
compounds.
The
existing
knowledge
concerning
phytosomes’
preparation,
characterization
well
commercially
available
with
alleviate
MDs
concisely
depicted.
brings
arguments
encourage
use
phytosome
formulation
diminish
risk
factors
inducing
MDs,
or
treat
already
installed
complementary
therapy
allopathic
medication.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 9411 - 9435
Опубликована: Сен. 1, 2024
extract
exhibits
antimalarial
activity,
mainly
due
to
its
secondary
metabolites-naphthoquinones,
flavonoids,
tannins,
and
saponins-where
naphthoquinone
is
the
primary
active
component.
However,
low
bioavailability
limits
effectiveness.
To
improve
this,
a
phytosome-based
vesicular
system
was
proposed.
This
study
focused
on
formulating
phytosome
with
Phytomedicine Plus,
Год журнала:
2024,
Номер
4(2), С. 100540 - 100540
Опубликована: Фев. 21, 2024
cancer
is
one
of
the
foremost
life-threatening
diseases
and
managed
by
various
strategies
like
surgery,
radiotherapy,
chemotherapy.
Among
all,
chemotherapy
most
preferential
strategy
for
management
but
faces
certain
limitations.
Phytochemicals
(PCs)
have
been
considered
potential
chemotherapeutics
chemopreventive
agents
their
clinical
application
can
be
questionable
because
poor
bioavailability
stability.
phytosomes
are
promising
carriers
to
deliver
anticancer
PCs
target
site
with
improved
stability
owing
unique
properties.
This
comprehensive
review
discusses
recent
advances
in
loaded
(covering
period
2013-December
2023)
overcome
limitations
PCs.
initially,
this
covers
that
under
trials
along
FDA-approved
(especially
management).
Here,
we
excluded
a)
an
experimental/preclinical
or
investigational
stage;
b)
possess
activity
other
than
anticancer;
c)
exhibit
combination
drugs;
d)
PC-based
drugs
anticancer.
Further,
article
mainly
emphasizes
Additionally,
cancer,
challenges,
future
directions
also
discussed.
versatile
alternatives
boost
PCs'
therapeutic
efficacy,
bioavailability,
specific
targeting
distinctive
structural
composition,
which
similar
composition
cell
membranes
enabling
them
close
physiological
systems.
Moreover,
these
vesicular
systems
increase
oral
polar
PCs,
protect
from
physical
chemical
degradation,
facilitate
efficiency
through
stimuli-responsive
sustained
release
Therefore,
will
help
researchers
develop
a
phytochemical-based
drug
delivery
system
successful
cancer.
