Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 13, 2025

Resveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties. Recent studies suggest that these effects are partly mediated through the regulation of macrophage polarization, wherein macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Our review highlights how resveratrol modulates polarization various signaling pathways to achieve therapeutic effects. For example, can activate senescence-associated secretory phenotype (SASP) pathway inhibit signal transducer activator transcription (STAT3) sphingosine-1-phosphate (S1P)-YAP axes, promoting suppressing thereby inhibiting tumor growth. Conversely, it promote suppress by NF-κB activating PI3K/Akt AMP-activated protein kinase (AMPK) pathways, thus alleviating inflammatory responses. Notably, effect on is concentration-dependent; moderate concentrations tend while higher may favor polarization. This concentration dependence offers new perspectives clinical treatment but also underscores necessity precise dosage control when using resveratrol. In summary, exhibits significant potential in regulating treating related diseases.

Язык: Английский

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Silybin: A Review of Its Targeted and Novel Agents for Treating Liver Diseases Based on Pathogenesis

Phytotherapy Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Liver disease represents a significant global public health concern. Silybin, derived from Silybum marianum, has been demonstrated to exhibit range of beneficial properties, including anti-inflammatory, antioxidative, antifibrotic, antiviral, and cytoprotective effects. These attributes render it promising candidate for the treatment liver fibrosis, cirrhosis, cancer, viral hepatitis, non-alcoholic fatty disease, other conditions. Nevertheless, its low solubility bioavailability have emerged as limitations in clinical application. To address these limitations, researchers developed number silybin formulations. This study presents comprehensive review results research on diseases recent decades, with particular focus novel formulations based pathogenesis disease. include approaches targeting via CD44 receptor, folic acid, vitamin A, others. Furthermore, findings studies that employed nanotechnology enhance silybin. includes use nanoparticles, liposomes, nanosuspensions. reviews application preparations diseases. However, further high-quality more complete experimental are still required gain understanding efficacy safety preparations. Finally, considers issues arise during

Язык: Английский

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Wogonin Mitigates Acetaminophen-Induced Liver Injury in Mice through Inhibition of the PI3K/AKT Signaling Pathway

Journal of Ethnopharmacology, Год журнала: 2024, Номер 332, С. 118364 - 118364

Опубликована: Май 18, 2024

Scutellaria baicalensis Georgi (SBG), a widely used traditional Chinese medicine, exhibits anti-inflammatory and antioxidant properties. Wogonin is one of the primary bioactive components SBG. Acetaminophen (APAP)-induced liver injury (AILI) represents prevalent form drug-induced damage primarily driven by inflammatory responses oxidative stress.

Язык: Английский

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Quercetin restores respiratory mucosal barrier dysfunction in Mycoplasma gallisepticum-infected chicks by enhancing Th2 immune response

Phytomedicine, Год журнала: 2024, Номер 133, С. 155953 - 155953

Опубликована: Авг. 12, 2024

Язык: Английский

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Fibrosis and Hepatocarcinogenesis: Role of Gene-Environment Interactions in Liver Disease Progression

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8641 - 8641

Опубликована: Авг. 8, 2024

The liver is a complex organ that performs vital functions in the body. Despite its extraordinary regenerative capacity compared to other organs, exposure chemical, infectious, metabolic and immunologic insults toxins renders vulnerable inflammation, degeneration fibrosis. Abnormal wound healing response mediated by aberrant signaling pathways causes chronic activation of hepatic stellate cells (HSCs) excessive accumulation extracellular matrix (ECM), leading fibrosis cirrhosis. Fibrosis plays key role carcinogenesis. Once thought be irreversible, recent clinical studies show can reversed, even advanced stage. Experimental evidence shows removal insult or injury inactivate HSCs reduce inflammatory response, eventually fibrolysis degradation ECM. Thus, it critical understand gene-environment interactions context progression regression order identify specific therapeutic targets for optimized treatment induce regression, prevent HCC development and, ultimately, improve outcome.

Язык: Английский

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Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Ноя. 29, 2023

Alcohol-associated liver disease (ALD) is a condition that develops due to prolonged and excessive alcohol consumption. It encompasses various stages of damage, including fatty liver, alcoholic hepatitis, cirrhosis. Immune cells, particularly macrophages, types play significant role in the onset progression disease. Macrophages observed exhibit diverse differentiation forms, perform range functions. Beyond M1 M2 human macrophages can polarize into distinct phenotypes response stimuli. Recent advancements have improved our understanding macrophage diversity their ALD. This mini-review provides concise overview latest findings on Additionally, it discusses potential therapeutic targets associated with explores strategies.

Язык: Английский

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Cardiomyocyte-derived Galectin-9 induces macrophage M2 polarization via the TIM3 pathway to attenuate myocardial remodeling post-myocardial infarction

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Язык: Английский

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The Metabolic Syndrome: An Overview and Proposed Mechanisms

Obesities, Год журнала: 2024, Номер 4(3), С. 226 - 255

Опубликована: Июль 22, 2024

Obesity has emerged as a major public health challenge in the 21st century, contributing to rising prevalence of metabolic syndrome (MetS), cluster interrelated risk factors. These factors include obesity or abdominal obesity, type 2 diabetes mellitus (T2DM), hypertension (HTN), and dyslipidaemia. In this review, we will explore important aspects regulation dynamics lipoprotein metabolism see how they underlie each these risks. Additionally, highlight role ferroptosis, an iron-dependent regulated cell death process, relation inflammatory responses its critical contribution pathophysiology MetS. inflammasome activation, lipotoxicity, influence adipocytokines, adipose tissue macrophages. By exploring interconnections, review aims provide insights into crosstalk, outline pathological mechanisms occurring, identify potential therapeutic targets for managing preventing progression

Язык: Английский

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B-Type Trimeric Procyanidins Attenuate Nonalcoholic Hepatic Steatosis Through AMPK/mTOR Signaling Pathway in Oleic Acid-Induced HepG2 Cells and High-Fat Diet- Fed Zebrafish

Plant Foods for Human Nutrition, Год журнала: 2025, Номер 80(1)

Опубликована: Янв. 23, 2025

NAFLD is one of the most common and rapidly increasing liver diseases. Procyanidin C1 procyanidin C2, B-type trimeric procyanidins, show beneficial effects on regulating lipid metabolism. However, mechanism underlying these remain elusive. Therefore, we investigated anti-NAFLD mechanisms C2 HFD- induced zebrafish OA-treated HepG2 cells. Network pharmacology, molecular docking dynamics simulations were used to predict potential targets analyze intermolecular forces. The results demonstrated that significantly reduce accumulation oxidative stress in both HFD-induced cell. And, treatment with enhance fatty acid oxidation improve mitochondria function. Furthermore, increased phosphorylated AMPKα levels inhibited mTOR, along downstream lipogenic proteins such as SREBP-1c, FAS, ACC, SCD-1 PPARγ.

Язык: Английский

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Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 7, 2025

Exosomes derived from pre-stimulated mesenchymal stem cells (MSCs) have improved therapeutic effects in disease-associated microenvironments. In this study, we investigated the potential of exosomes MSCs stimulated with plasma patients liver failure (LF-Exos). Untreated (NC-Exos) and LF-Exos were extracted characterized by nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), western blotting, miRNA sequencing. We then examined protective on hepatocytes acutely injured D-galactosamine (D-GalN)/lipopolysaccharide (LPS) co-treatment a mouse model acute (ALF). Apoptosis was assessed using CCK-8 assay flow cytometry. Liver tissue damage hematoxylin eosin staining immunohistochemistry. The levels signaling pathway proteins determined blotting. Stimulation significantly altered morphology reduced their proliferative activity. Gene chip identified 31 differentially expressed miRNAs, further showed that these miRNAs may affect PI3K-AKT pathway. Compared to NC-Exos, induced AKT phosphorylation tissues, inhibited D-GalN/LPS-induced apoptosis hepatocytes, pathological injury ALF. biological Exos after stimulation failure. inhibit activity NLRP3 inflammasome activate exert

Язык: Английский

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