Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 13, 2025
Resveratrol,
a
polyphenolic
compound
known
for
its
diverse
biological
activities,
has
demonstrated
multiple
pharmacological
effects,
including
anti-inflammatory,
anti-aging,
anti-diabetic,
anti-cancer,
and
cardiovascular
protective
properties.
Recent
studies
suggest
that
these
effects
are
partly
mediated
through
the
regulation
of
macrophage
polarization,
wherein
macrophages
differentiate
into
pro-inflammatory
M1
or
anti-inflammatory
M2
phenotypes.
Our
review
highlights
how
resveratrol
modulates
polarization
various
signaling
pathways
to
achieve
therapeutic
effects.
For
example,
can
activate
senescence-associated
secretory
phenotype
(SASP)
pathway
inhibit
signal
transducer
activator
transcription
(STAT3)
sphingosine-1-phosphate
(S1P)-YAP
axes,
promoting
suppressing
thereby
inhibiting
tumor
growth.
Conversely,
it
promote
suppress
by
NF-κB
activating
PI3K/Akt
AMP-activated
protein
kinase
(AMPK)
pathways,
thus
alleviating
inflammatory
responses.
Notably,
effect
on
is
concentration-dependent;
moderate
concentrations
tend
while
higher
may
favor
polarization.
This
concentration
dependence
offers
new
perspectives
clinical
treatment
but
also
underscores
necessity
precise
dosage
control
when
using
resveratrol.
In
summary,
exhibits
significant
potential
in
regulating
treating
related
diseases.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 23, 2024
Liver
disease
represents
a
significant
global
public
health
concern.
Silybin,
derived
from
Silybum
marianum,
has
been
demonstrated
to
exhibit
range
of
beneficial
properties,
including
anti-inflammatory,
antioxidative,
antifibrotic,
antiviral,
and
cytoprotective
effects.
These
attributes
render
it
promising
candidate
for
the
treatment
liver
fibrosis,
cirrhosis,
cancer,
viral
hepatitis,
non-alcoholic
fatty
disease,
other
conditions.
Nevertheless,
its
low
solubility
bioavailability
have
emerged
as
limitations
in
clinical
application.
To
address
these
limitations,
researchers
developed
number
silybin
formulations.
This
study
presents
comprehensive
review
results
research
on
diseases
recent
decades,
with
particular
focus
novel
formulations
based
pathogenesis
disease.
include
approaches
targeting
via
CD44
receptor,
folic
acid,
vitamin
A,
others.
Furthermore,
findings
studies
that
employed
nanotechnology
enhance
silybin.
includes
use
nanoparticles,
liposomes,
nanosuspensions.
reviews
application
preparations
diseases.
However,
further
high-quality
more
complete
experimental
are
still
required
gain
understanding
efficacy
safety
preparations.
Finally,
considers
issues
arise
during
Journal of Ethnopharmacology,
Journal Year:
2024,
Volume and Issue:
332, P. 118364 - 118364
Published: May 18, 2024
Scutellaria
baicalensis
Georgi
(SBG),
a
widely
used
traditional
Chinese
medicine,
exhibits
anti-inflammatory
and
antioxidant
properties.
Wogonin
is
one
of
the
primary
bioactive
components
SBG.
Acetaminophen
(APAP)-induced
liver
injury
(AILI)
represents
prevalent
form
drug-induced
damage
primarily
driven
by
inflammatory
responses
oxidative
stress.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8641 - 8641
Published: Aug. 8, 2024
The
liver
is
a
complex
organ
that
performs
vital
functions
in
the
body.
Despite
its
extraordinary
regenerative
capacity
compared
to
other
organs,
exposure
chemical,
infectious,
metabolic
and
immunologic
insults
toxins
renders
vulnerable
inflammation,
degeneration
fibrosis.
Abnormal
wound
healing
response
mediated
by
aberrant
signaling
pathways
causes
chronic
activation
of
hepatic
stellate
cells
(HSCs)
excessive
accumulation
extracellular
matrix
(ECM),
leading
fibrosis
cirrhosis.
Fibrosis
plays
key
role
carcinogenesis.
Once
thought
be
irreversible,
recent
clinical
studies
show
can
reversed,
even
advanced
stage.
Experimental
evidence
shows
removal
insult
or
injury
inactivate
HSCs
reduce
inflammatory
response,
eventually
fibrolysis
degradation
ECM.
Thus,
it
critical
understand
gene-environment
interactions
context
progression
regression
order
identify
specific
therapeutic
targets
for
optimized
treatment
induce
regression,
prevent
HCC
development
and,
ultimately,
improve
outcome.
Plant Foods for Human Nutrition,
Journal Year:
2025,
Volume and Issue:
80(1)
Published: Jan. 23, 2025
NAFLD
is
one
of
the
most
common
and
rapidly
increasing
liver
diseases.
Procyanidin
C1
procyanidin
C2,
B-type
trimeric
procyanidins,
show
beneficial
effects
on
regulating
lipid
metabolism.
However,
mechanism
underlying
these
remain
elusive.
Therefore,
we
investigated
anti-NAFLD
mechanisms
C2
HFD-
induced
zebrafish
OA-treated
HepG2
cells.
Network
pharmacology,
molecular
docking
dynamics
simulations
were
used
to
predict
potential
targets
analyze
intermolecular
forces.
The
results
demonstrated
that
significantly
reduce
accumulation
oxidative
stress
in
both
HFD-induced
cell.
And,
treatment
with
enhance
fatty
acid
oxidation
improve
mitochondria
function.
Furthermore,
increased
phosphorylated
AMPKα
levels
inhibited
mTOR,
along
downstream
lipogenic
proteins
such
as
SREBP-1c,
FAS,
ACC,
SCD-1
PPARγ.
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 7, 2025
Exosomes
derived
from
pre-stimulated
mesenchymal
stem
cells
(MSCs)
have
improved
therapeutic
effects
in
disease-associated
microenvironments.
In
this
study,
we
investigated
the
potential
of
exosomes
MSCs
stimulated
with
plasma
patients
liver
failure
(LF-Exos).
Untreated
(NC-Exos)
and
LF-Exos
were
extracted
characterized
by
nanoparticle
tracking
analysis
(NTA),
transmission
electron
microscopy
(TEM),
western
blotting,
miRNA
sequencing.
We
then
examined
protective
on
hepatocytes
acutely
injured
D-galactosamine
(D-GalN)/lipopolysaccharide
(LPS)
co-treatment
a
mouse
model
acute
(ALF).
Apoptosis
was
assessed
using
CCK-8
assay
flow
cytometry.
Liver
tissue
damage
hematoxylin
eosin
staining
immunohistochemistry.
The
levels
signaling
pathway
proteins
determined
blotting.
Stimulation
significantly
altered
morphology
reduced
their
proliferative
activity.
Gene
chip
identified
31
differentially
expressed
miRNAs,
further
showed
that
these
miRNAs
may
affect
PI3K-AKT
pathway.
Compared
to
NC-Exos,
induced
AKT
phosphorylation
tissues,
inhibited
D-GalN/LPS-induced
apoptosis
hepatocytes,
pathological
injury
ALF.
biological
Exos
after
stimulation
failure.
inhibit
activity
NLRP3
inflammasome
activate
exert
Frontiers in Cell and Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11
Published: Nov. 29, 2023
Alcohol-associated
liver
disease
(ALD)
is
a
condition
that
develops
due
to
prolonged
and
excessive
alcohol
consumption.
It
encompasses
various
stages
of
damage,
including
fatty
liver,
alcoholic
hepatitis,
cirrhosis.
Immune
cells,
particularly
macrophages,
types
play
significant
role
in
the
onset
progression
disease.
Macrophages
observed
exhibit
diverse
differentiation
forms,
perform
range
functions.
Beyond
M1
M2
human
macrophages
can
polarize
into
distinct
phenotypes
response
stimuli.
Recent
advancements
have
improved
our
understanding
macrophage
diversity
their
ALD.
This
mini-review
provides
concise
overview
latest
findings
on
Additionally,
it
discusses
potential
therapeutic
targets
associated
with
explores
strategies.
Obesities,
Journal Year:
2024,
Volume and Issue:
4(3), P. 226 - 255
Published: July 22, 2024
Obesity
has
emerged
as
a
major
public
health
challenge
in
the
21st
century,
contributing
to
rising
prevalence
of
metabolic
syndrome
(MetS),
cluster
interrelated
risk
factors.
These
factors
include
obesity
or
abdominal
obesity,
type
2
diabetes
mellitus
(T2DM),
hypertension
(HTN),
and
dyslipidaemia.
In
this
review,
we
will
explore
important
aspects
regulation
dynamics
lipoprotein
metabolism
see
how
they
underlie
each
these
risks.
Additionally,
highlight
role
ferroptosis,
an
iron-dependent
regulated
cell
death
process,
relation
inflammatory
responses
its
critical
contribution
pathophysiology
MetS.
inflammasome
activation,
lipotoxicity,
influence
adipocytokines,
adipose
tissue
macrophages.
By
exploring
interconnections,
review
aims
provide
insights
into
crosstalk,
outline
pathological
mechanisms
occurring,
identify
potential
therapeutic
targets
for
managing
preventing
progression
