Unveiling potent Schiff base derivatives with selective xanthine oxidase inhibition: In silico and in vitro approach

Saudi Pharmaceutical Journal, Год журнала: 2024, Номер 32(5), С. 102062 - 102062

Опубликована: Апрель 4, 2024

This research describes the synthesis by an environmentally-friendly method, microwave irradiation, development and analysis of three novel one previously identified Schiff base derivative as a potential inhibitor bovine xanthine oxidase (BXO), key enzyme implicated in progression gout. Meticulous experimentation revealed that these compounds (

Язык: Английский

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Research progress on antioxidants and protein aggregation inhibitors in cataract prevention and therapy (Review)

Molecular Medicine Reports, Год журнала: 2024, Номер 31(1)

Опубликована: Ноя. 7, 2024

Cataracts are primarily caused by aging or gene mutations and the leading cause of blindness globally. As older population increases, number patients with a cataract is expected to grow rapidly. At present, surgery replace lens an artificial intraocular principal treatment method. However, has several drawbacks, including economic burdens complications such as inflammation, xerophthalmia, macular edema posterior capsular opacification. Thus, developing effective non‑surgical strategy beneficial both public health. Mechanistically, formation may be due various reasons but initiated promoted oxidative stress closely associated crystallin aggregation. In present review, current research progress on anti‑cataract drugs, antioxidants protein aggregation inhibitors examined. It summarizes strategies for preventing treating through cell apoptosis inhibition while discussing their limitations further prospects. 

Язык: Английский

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Increased V-ATPase activity can lead to chemo-resistance in oral squamous cell carcinoma via autophagy induction: new insights

Medical Oncology, Год журнала: 2024, Номер 41(5)

Опубликована: Апрель 9, 2024

Язык: Английский

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Designing and Synthesis of Novel Fexofenadine‐Derived Hydrazone‐Schiff bases as Potential Urease Inhibitors: In‐Vitro, Molecular Docking and DFT Investigations

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(8)

Опубликована: Май 23, 2024

Thirteen novel hydrazone-Schiff bases (3-15) of fexofenadine were succesfully synthesized, structurally deduced and finally assessed their capability to inhibit urease enzyme (in vitro). In the series, six compounds 12 (IC

Язык: Английский

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Cartilage tissue engineering using decellularized biomatrix hydrogel containing TGF-β-loaded alginate microspheres in mechanically loaded bioreactor

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 25, 2024

Abstract Physiochemical tissue inducers and mechanical stimulation are both efficient variables in cartilage fabrication regeneration. In the presence of biomolecules, decellularized extracellular matrix (ECM) may trigger enhance stem cell proliferation differentiation. Here, we investigated controlled release transforming growth factor beta (TGF-β1) as an active mediator mesenchymal stromal cells (MSCs) a biocompatible scaffold for engineering. ECM-derived hydrogel with TGF-β1-loaded alginate-based microspheres (MSs) was created to promote human MSC chondrogenic development. Ex vivo explants complicated multiaxial loading bioreactor replicated physiological conditions. Hydrogels with/without MSs TGF-β1 were highly cytocompatible. MSCs containing TGF-β1/MSs showed comparable gene expression levels those hydrogels added culture media or without TGF-β1. However, constructs directly within had inferior properties under unloaded The group including circumstances formed better ex osteochondral defect than control settings. This study demonstrates that local delivery using is essential neocartilage formation by further optimization needed prevent differentiation towards hypertrophy.

Язык: Английский

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Nanoparticle-mediated metronomic chemotherapy in cancer: A paradigm of precision and persistence

Cancer Letters, Год журнала: 2024, Номер 594, С. 216990 - 216990

Опубликована: Май 25, 2024

Язык: Английский

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Regulation of the Nrf2/HO-1 axis by mesenchymal stem cells-derived extracellular vesicles: implications for disease treatment

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Июнь 10, 2024

This comprehensive review inspects the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) across multiple organ systems. Examining their impact on integumentary, respiratory, cardiovascular, urinary, and skeletal systems, study highlights versatility MSC-EVs in addressing diverse medical conditions. Key pathways, such as Nrf2/HO-1, consistently emerge central mediators antioxidative anti-inflammatory effects. From expediting diabetic wound healing to mitigating oxidative stress-induced skin injuries, alleviating acute lung even offering solutions for conditions like myocardial infarction renal ischemia-reperfusion injury, demonstrate promising efficacy. Their adaptability different administration routes identifying specific factors opens avenues innovative regenerative strategies. positions candidates future clinical applications, providing a overview medicine.

Язык: Английский

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Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

The reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect the response. Metabolic intermediates accumulate a result adaptations mediate functions outside metabolism regulation immunity inflammation. In macrophages, there been major focus on 3 metabolites linked to Krebs cycle, itaconate, succinate, fumarate, which have shown regulate multiple processes. Here, we discuss recent progress these with regard their effect macrophages host defense inflammatory diseases. We also consider therapeutic opportunities presented from mimicry or by targeting enzymes that make metabolize them order leverage body's own anti-inflammatory

Язык: Английский

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One-pot four-component synthesis of some novel hydrazone-Schiff bases of polyhydroquinoline as potent tyrosinase inhibitors: in vitro, molecular docking and simulations approaches

Journal of Biomolecular Structure and Dynamics, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Май 5, 2025

Seventeen novel polyhydroquinoline (1) based Schiff bases (4-20) were synthesized in excellent yields through Hantzsch reaction, characterized by means of spectroscopic techniques and finally screened for their vitro tyrosinase inhibitory potential. Among the series, five compounds 12 (IC50 = 8.93 ± 0.27 µM), 8 16.64 0.32 5 17.74 0.34 4 18.46 0.37 µM) 18 18.64 0.39 found potent inhibitors enzyme comparing with kojic acid 18.30 0.41 µM). Likewise, eight derivatives 7, 15, 9, 6, 10, 13, 14 11 ascribed significant activity having IC50 values 20.72 0.45, 22.53 0.61, 24.17 0.40, 25.72 0.60, 26.43 0.39, 27.90 0.53, 28.37 0.59 29.15 0.64 µM respectively, while remaining four hydrazone-Schiff 19, 20, 17 16 exhibited good to less potential range from 31.58 0.67 63.69 1.30 µM. Docking studies indicate binding hydrazide moiety most active compound site residues tyrosinase. The molecular dynamic simulation indicates that showed root mean square deviation profile complexes stabilized at low nanoseconds, indicating stable conformations. These did not induce structural changes protein.

Язык: Английский

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Microfluidics devices for sports: A review on technology for biomedical application used in fields such as biomedicine, drug encapsulation, preparation of nanoparticles, cell targeting, analysis, diagnosis, and cell culture

Tissue and Cell, Год журнала: 2024, Номер 87, С. 102339 - 102339

Опубликована: Март 2, 2024

Язык: Английский

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