Diabetes Metabolic Syndrome and Obesity, Год журнала: 2024, Номер Volume 17, С. 4105 - 4113
Опубликована: Ноя. 1, 2024
Diabetes kidney disease (DKD) is a common complication of diabetes and currently considered the primary cause end-stage renal disease. Ferroptosis has been found to participate in development DKD. However, no ferroptosis-related markers have evaluated human DKD samples. This study aimed examine pathological alterations
Язык: Английский
Cancers, Год журнала: 2024, Номер 16(3), С. 601 - 601
Опубликована: Янв. 31, 2024
Germline inactivation of the Von Hippel-Lindau (VHL) tumor suppressor is defining hallmark in hereditary VHL disease and VHL-associated renal cell carcinoma (RCC). However, somatic mutations are also observed patients with sporadic RCC. Loss function result constitutive activation hypoxia-inducible factor-2 alpha (HIF-2α), which leads to increased expression HIF target genes that promote angiogenesis growth. As 2023, belzutifan currently only approved HIF-2α inhibitor for both metastatic RCC (mRCC). there potential resistance inhibitors warrants novel HIF-2α-targeting strategies. In this review, we discuss mechanisms current clinical trials evaluating combinations other targeted therapies immune checkpoint may enhance efficacy targeting. Lastly, newer generation under early investigation outline future directions challenges mRCC.
Язык: Английский
Процитировано
11
Veterinary Research, Год журнала: 2024, Номер 55(1)
Опубликована: Авг. 18, 2024
Porcine reproductive and respiratory syndrome virus (PRRSV) is a severe disease with substantial economic consequences for the swine industry. The DEAD-box helicase 3 (DDX3X) an RNA that plays crucial role in regulating metabolism, immunological response, even infection. However, it unclear whether contributes to PRRSV Recent studies have found expression of DDX3X considerably increases Marc-145 cells when infected live strains Ch-1R SD16; however, was observed inactivated viruses did not lead any changes. By using RK-33 inhibitor or DDX3X-specific siRNAs reduce expression, there significant decrease production progenies. In contrast, overexpression host substantially increased proliferation PRRSV. A combination transcriptomics metabolomics investigations revealed PRRSV-infected cells, gene silencing severely affected biological processes such as ferroptosis, FoxO signalling pathway, glutathione metabolism. subsequent transmission electron microscopy (TEM) imaging displayed typical ferroptosis features mitochondrial shrinkage, reduction disappearance cristae, cytoplasmic membrane rupture. Conversely, morphology unchanged DDX3X-inhibited cells. Furthermore, changed ferroptosis-related genes inhibited proliferation, while drug-induced inversely promoted replication. summary, these results present updated perspective how infection uses self-replication, potentially leading via various mechanisms promote
Язык: Английский
Процитировано
4
Biological Trace Element Research, Год журнала: 2024, Номер 202(10), С. 4674 - 4686
Опубликована: Янв. 4, 2024
Язык: Английский
Процитировано
3
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Окт. 9, 2024
The prevalence of urological malignancies remains a significant global health concern, particularly given the challenging prognosis for patients in advanced disease stages. Consequently, there is pressing need to explore molecular mechanisms that regulate development discover novel breakthroughs diagnosis and treatment. Ferroptosis, characterized by iron-ion-dependent lipid peroxidation, form programmed cell death (PCD) distinct from apoptosis, autophagy, necrosis. Notably, lipid, iron, glutathione metabolism intricately intracellular ferroptosis, playing essential roles progression various neoplasms drug resistance. In recent years, ferroptosis has been found be closely related malignancies. This paper provides an overview involvement pathogenesis malignancies, elucidates governing its regulation, synthesizes diagnosing treating these We aim provide new direction clinical treatment
Язык: Английский
Процитировано
3
Experimental Cell Research, Год журнала: 2025, Номер unknown, С. 114497 - 114497
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
EMBO Molecular Medicine, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
Abstract The oncogenic mechanisms by which TFE3 fusion proteins drive translocation renal cell carcinoma (tRCC) are poorly characterized. Here, we integrated loss and gain of function experiments with multi-omics analyses in tRCC lines patient tumors. High nuclear accumulation NONO-TFE3 or PRCC-TFE3 promotes their broad binding across the genome at H3K27ac-marked active chromatin, engaging a core set M/E-box-containing regulatory elements to activate specific gene expression programs as well promiscuous promoters stimulate mRNA synthesis. Within program, fusions directly regulate genes involved ferroptosis resistance oxidative phosphorylation metabolism (OxPhos). Consequently, human tumors display high OxPhos scores that persist during epithelial mesenchymal transition (EMT). We further show tumor aggressiveness is related EMT associated enrichment myofibroblast cancer-associated fibroblasts (myCAFs) both hallmarks poor prognostic outcomes. define novel metabolic subtype cancer provide unique insights into how genomic regulates resistance.
Язык: Английский
Процитировано
0
Cell Biology and Toxicology, Год журнала: 2025, Номер 41(1)
Опубликована: Май 30, 2025
Macrophages are closely associated with the progression of Kidney renal clear cell carcinoma (KIRC) and can influence programmed death (PCD) tumour cells. To identify prognostic biomarkers for KIRC, it is essential to investigate association between macrophage-related genes PCD characteristics. Clinical details transcriptome data from 693 KIRC samples were obtained multiple databases, including TCGA GEO. Genes macrophages identified key regulatory patterns analyzed. The relationship 18 types under investigation a powerful computational framework. Ten machine learning algorithms, 101 unique combinations algorithms utilized build macrophage-associated (MacPCD) model predict patient survival. Immunohistochemistry RT-qPCR used genetic analysis MacPCD models. made up six which showed strong predictive power prognosis patients KIRC. that among genes, BID, SLC25A37 BNIP3L highly expressed in tissues, whereas ACSL1, SDHB ALDH2 normal tissues. Biologically, high group higher tumor mutation burden increased immune infiltration expression immunomodulators. In particular, was an independent indicator best predictor survival (AUC = 0.920) compared clinical variables (Age, M, Stage). We framework highlight great potential providing personalised risk assessment immunotherapy intervention recommendations patients.
Язык: Английский
Процитировано
0
BioFactors, Год журнала: 2023, Номер 50(2), С. 266 - 293
Опубликована: Дек. 7, 2023
Ferroptosis is a new form of regulated cell death caused by iron-dependent accumulation lethal polyunsaturated phospholipids peroxidation. It has received considerable attention owing to its putative involvement in wide range pathophysiological processes such as organ injury, cardiac ischemia/reperfusion, degenerative disease and prevalence plants, invertebrates, yeasts, bacteria, archaea. To counter ferroptosis, living organisms have evolved myriad intrinsic efficient defense systems, cyst(e)ine-glutathione-glutathione peroxidase 4 system (cyst(e)ine-GPX4 system), guanosine triphosphate cyclohydrolase 1/tetrahydrobiopterin (BH
Язык: Английский
Процитировано
6
Life Sciences, Год журнала: 2024, Номер 358, С. 123190 - 123190
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
1
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Ноя. 23, 2024
Язык: Английский
Процитировано
1