Numerical simulation of the influence of microchannel flow field on particle separation under changes in geometric structure

Physics of Fluids, Год журнала: 2025, Номер 37(1)

Опубликована: Янв. 1, 2025

This paper systematically investigated the microfluidic chip with inertial contraction and expansion channels based on numerical simulation methods. The influence of geometric shape changes particle separation effect was focused on. We varied microchannel structural parameters such as channel length width, overall curvature microchannel. results indicated that different structures hold diverse effects recovery rate. An appropriate shrinkage–expansion ratio can improve effect. In microchannel, we found six seven are optimal structure, which capable achieving effective three types particles. vortex structure in dramatically impacts focusing width particles distance particles, may be considered internal mechanism to explain trajectory channel. Furthermore, has a great rate As degree bending leaps, will first decrease then increase. study establishes theoretical foundation for understanding interaction between diversifications chips efficiency.

Язык: Английский

---

Zweifach–Fung Microfluidic Device for Efficient Microparticle Separation: Cost-Effective Fabrication Using CO2 Laser-Ablated PMMA

Micromachines, Год журнала: 2024, Номер 15(7), С. 932 - 932

Опубликована: Июль 22, 2024

Microfluidic separators play a pivotal role in the biomedical and chemical industries by enabling precise fluid manipulations. Traditional fabrication of these devices typically requires costly cleanroom facilities, which limits their broader application. This study introduces novel microfluidic device that leverages passive Zweifach–Fung principle to overcome financial barriers. Through Lagrangian computational simulations, we optimized an eleven-channel configuration achieved perfect 100% recall rate for particles following specified normal distribution. Experimental evaluations determined 2 mL/h as optimal total flow (TFR), under showcased exceptional performance enhancements precision micrometer-sized particles, achieving overall accuracy 94% ± 3%. Fabricated using cost-effective, non-cleanroom method, this approach represents significant shift from conventional practices, dramatically reducing production costs while maintaining high operational efficacy. The cost each chip is less than USD 0.90 cents manufacturing process takes only 15 min. development not makes technology more accessible but also sets new standard future advancements field.

Язык: Английский

---

Isolation Techniques of Micro/Nano‐Scaled Species for Biomedical Applications

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 24, 2025

Abstract Isolation of micro/nano‐scaled bioparticles, such as circulating tumor cells (CTCs), exosomes, bacteria, white blood (WBCs), platelets, and viruses, from the sample is essential for cancer diagnosis treatment, preventing bacterial infections, monitoring human health. Numerous separation techniques, including magnetophoresis, dielectrophoresis, acoustophoresis, optophoresis, fluorescence‐activated sorting (FAS) have been developed to isolate target bioparticles complex samples accurately. However, these active methods usually rely on sophisticated instruments which are expensive bulky. Passive platforms with high throughput, low cost, small volume gradually become alternative methods. Alongside this context, review paper no longer confined one specific category isolation advanced systems that in recent years comprehensively introduced. Characteristics limitations each technology discussed according critical performance parameters purity, recovery rate, resolution, size, convenience. Specific biomedical applications techniques summarized provide practical implications disease diagnosis, mechanism research. This also addresses current challenges, potential solutions, prospects field, laying foundation further optimization, innovation, cross‐integration future.

Язык: Английский

---

High-throughput separation of microalgae on a runway-shaped channel with ordered semicircular micro-obstacles

Microfluidics and Nanofluidics, Год журнала: 2024, Номер 28(12)

Опубликована: Ноя. 23, 2024

Язык: Английский

---

High-throughput separation of microalgae on a runway-shaped channel with ordered semicircular micro-obstacles

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 23, 2024

Microalgae serve as a valuable biological resource in many industrial applications. Thus, it is essential to obtain high-efficiency separation technique for microalgae precisely. In this study, runway-shaped microchannel with ordered semicircular micro-obstacles was introduced conduct the of different sizes. The combined spiral characteristics series realize advantage sheathless, high-throughput, and low aspect ratio configuration. These improved performance particle focusing, which can promote effectively. simulated results demonstrated that channel could form evident distribution local Dean vortices separate particles size or volume. When flow rate considered 4mL/min, experiment indicated Chlorella vulgaris Haematococcus pluvialis 94.6% 81.5%, respectively. high throughput efficiency competent carry out task microalgal screening artificial cultivation.

Язык: Английский

---

Microfluidic chip-assisted separation process and post-chip microalgae cultivation for carotenoid production

Journal of Applied Phycology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 27, 2024

Язык: Английский

---