Plant Secondary Metabolites as Modulators of Mitochondrial Health: An Overview of Their Anti-Oxidant, Anti-Apoptotic, and Mitophagic Mechanisms
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 380 - 380
Опубликована: Янв. 4, 2025
Plant
secondary
metabolites
(PSMs)
are
a
diverse
group
of
bioactive
compounds,
including
flavonoids,
polyphenols,
saponins,
and
terpenoids,
which
have
been
recognised
for
their
critical
role
in
modulating
cellular
functions.
This
review
provides
comprehensive
analysis
the
effects
PSMs
on
mitochondrial
health,
with
particular
emphasis
therapeutic
potential.
Emerging
evidence
shows
that
these
improve
function
by
reducing
oxidative
stress,
promoting
biogenesis,
regulating
key
processes
such
as
apoptosis
mitophagy.
Mitochondrial
dysfunction,
hallmark
many
pathologies,
neurodegenerative
disorders,
cardiovascular
diseases,
metabolic
syndrome,
has
shown
to
benefit
from
protective
PSMs.
Recent
studies
show
can
dynamics,
stabilise
membranes,
enhance
bioenergetics,
offering
significant
promise
prevention
treatment
mitochondrial-related
diseases.
The
molecular
mechanisms
underlying
effects,
modulation
signalling
pathways
direct
interactions
proteins,
discussed.
integration
into
strategies
is
highlighted
promising
avenue
improving
efficacy
while
minimising
side
commonly
associated
synthetic
drugs.
also
highlights
need
future
research
elucidate
specific
roles
individual
synergistic
within
complex
plant
matrices,
may
further
optimise
utility.
Overall,
this
work
valuable
insights
health
potential
natural
agents
targeting
dysfunction.
Язык: Английский
Neurobiological potential of astragaloside IV and prospects for its use in the treatment of Alzheimer’s disease
S S Korsakov Journal of Neurology and Psychiatry,
Год журнала:
2025,
Номер
125(2), С. 7 - 7
Опубликована: Март 6, 2025
The
review
presents
an
analysis
of
experimental
data
on
the
study
neurobiological
effects
astragaloside
IV,
which
can
be
used
in
treatment
Alzheimer's
disease.
Astragaloside
IV
is
a
cycloartan
triterpene
saponin,
found
roots
membranous
milk
vetch
(Astragalus
membranaceus
(Fisch.
ex
Link)
Bunge)
and
has
very
wide
range
pharmacological
activity.
In
recent
years,
this
compound
attracted
attention
due
to
its
diverse
effects.
Studies
have
shown
ability
modulate
microglial
protective
effect
saponin
neurons
from
glutamate-induced
neurotoxicity
been
demonstrated.
PC12
cells,
able
resolve
various
types
mitochondrial
dysfunction
inhibit
endoplasmic
reticulum
stress.
This
also
PPARγ
agonist.
vivo
experiments
that
test
substance
effectively
protects
synapses
as
well
improves
cognitive
functions,
including
memory
learning.
It
concluded
apparently,
may
future
multi-purpose
complex
therapy
for
Язык: Английский
Polysaccharides, saponins and flavonoids in Astragali Radix: a review of phytochemistry and pharmacology for future therapeutic applications
Phytochemistry Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Astragaloside IV protects against autoimmune myasthenia gravis in rats via regulation of mitophagy and apoptosis
Molecular Medicine Reports,
Год журнала:
2024,
Номер
30(1)
Опубликована: Май 24, 2024
Astragaloside
IV
(AS‑IV)
has
various
pharmacological
effects,
including
antioxidant
and
immunoregulatory
properties,
which
can
improve
myasthenia
gravis
(MG)
symptoms.
However,
the
potential
mechanism
underlying
effects
of
AS‑IV
on
MG
remains
to
be
elucidated.
The
present
study
aimed
investigate
whether
a
therapeutic
effect
its
action.
By
subcutaneously
immunizing
rats
with
R97‑116
peptide,
an
experimental
autoimmune
(EA)
rat
model
was
established.
(40
or
80
mg/kg/day)
treatment
then
applied
for
28
days
after
modeling.
results
demonstrated
that
significantly
ameliorated
weight
loss,
Lennon
score
pathological
changes
in
gastrocnemius
muscle
EAMG
compared
group.
Additionally,
levels
acetylcholine
receptor
antibody
(AChR‑Ab)
were
decreased,
whereas
mitochondrial
function
[ATPase
cytochrome
c
(Cyt‑C)
oxidase
activities]
ultrastructure
improved
treated
rats.
Moreover,
mRNA
protein
expression
phosphatase
tensin
homolog‑induced
putative
kinase
1,
Parkin,
LC3II
Bcl‑2,
key
signaling
molecules
mitophagy
apoptosis,
upregulated,
p62,
Cyt‑C,
Bax,
caspase
3
9
downregulated
following
intervention.
In
conclusion,
may
protect
against
by
modulating
apoptosis.
These
findings
indicated
provided
novel
insights
into
strategies
MG.
Язык: Английский
Astragalus membranaceus, Nigella sativa, and Perilla frutescens as Immunomodulators—Molecular Mechanisms and Clinical Effectiveness in Allergic Diseases
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(8), С. 9016 - 9032
Опубликована: Авг. 17, 2024
Plants
are
the
source
of
numerous
remedies
in
modern
medicine,
and
some
them
have
been
studied
due
to
their
potential
immunomodulatory
activity.
Astragalus
membranaceus
Fisch.
ex
Bunge
(A.
membranaceus),
Nigella
sativa
L.
(N.
sativa),
Perilla
frutescens
(L.)
Britton
(P.
frutescens)
plant
species
used
traditional
medicine
for
treatment
various
diseases.
Their
act
as
immunomodulatory,
anti-inflammatory,
anti-allergic
agents
makes
interesting
investigating
clinical
alleviating
symptoms
allergic
Allergy
affects
a
large
number
people;
according
sources
more
than
30%
world
population
suffer
from
type
reaction,
with
pollen
allergy
most
common
type.
Treatment
is
usually
pharmacological
may
not
be
completely
effective
or
side
effects.
Thus,
we
seeking
mostly
medicinal
plants,
promising
symptoms.
A
literature
overview
was
conducted
employing
databases
such
Scopus,
PubMed,
Web
Science,
Springer,
Google
Scholar.
This
manuscript
summarizes
recent
vivo
preclinical
studies
on
three
activity,
provides
comparison
effects,
underlines
application
practice.
The
obtained
results
confirmed
efficacy
studies,
but
also
emphasize
problem
phytochemical
characterization
difference
between
tested
doses.
More
trials
standardized
protocols
(defined
active
molecules,
dosage,
effects)
required
obtain
safe
herbal
drugs.
Язык: Английский
Separation of astragaloside IV from Astragalus membranaceus based on high‐speed countercurrent chromatography in continuous injection mode
Phytochemical Analysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 26, 2024
Abstract
Introduction
Astragaloside
IV
(AS‐IV)
is
an
index
for
the
quality
evaluation
of
traditional
Chinese
medicine
Astragalus
and
important
material
basis
to
exert
its
medicinal
effects,
it
difficult
obtain
a
single
AS‐IV
by
ordinary
separation
methods.
Objective
To
find
new
isolation
method
that
can
prepare
quickly
efficiently.
Methodology
was
isolated
from
membranaceus
extract
high‐speed
countercurrent
chromatography
using
two‐phase
solvent
system
consisting
ethyl
acetate/
n
‐butanol/water
(4.2:0.8:5,
v/v)
at
speed
950
rpm
flow
rate
2
mL/min
one
chromatographic
sequential
injection
models
developed
during
previous
study.
Results
Compared
with
common
separation,
this
increased
volume
yield
4‐fold
4.47‐fold,
respectively,
only
about
1.2‐fold
increase
in
consumption
time,
purity
basically
not
reduced,
55.9
mg
AS‐IV,
96.95%,
finally
prepared
400
crude
240
min.
Conclusion
The
continuous
mode
able
successfully
large
amount
high
time.
Язык: Английский
GATA1‐activated lncRNA OIP5‐AS1 and GAS5 promote pyroptosis to exacerbate asthma through regulating miR‐136‐5p/LIFR axis
The FASEB Journal,
Год журнала:
2024,
Номер
38(22)
Опубликована: Ноя. 13, 2024
Abstract
Pyroptosis
plays
a
pivotal
role
in
airway
epithelial
inflammation
during
the
progression
of
asthma.
This
study
aimed
to
explore
influence
and
mechanisms
opa‐interacting
protein
5
antisense
RNA1
(OIP5‐AS1)
growth
arrest‐specific
transcript
(GAS5)
on
pyroptosis
asthmatic
models.
was
induced
Dermatophagoides
pteronyssinus
1
(Der
p1)‐exposed
16HBE
cells
ovalbumin
(OVA)‐challenged
rats.
Subsequently,
its
related
molecular
were
investigated.
Our
results
indicated
that
GATA1,
OIP5‐AS1,
GAS5,
LIFR
upregulated,
while
miR‐136‐5p
downregulated
patients
experimental
models
OIP5‐AS1/GAS5
knockdown
repressed
NLRP3
inflammasome‐mediated
cells.
Mechanistically,
sponged
enhance
expression
subsequently
activated
NF‐κB
pathway.
or
LIFR‐mediated
induction
abrogated
by
mimics
inhibitors
(BAY11‐7082).
Finally,
GATA1
transcriptionally
trigger
pyroptosis,
thereby
driving
asthma
vivo
vitro.
In
conclusion,
promoted
via
modulation
miR‐136‐5p/LIFR/NF‐κB
axis
consequently
resulted
may
provide
novel
therapeutic
strategies
for
Язык: Английский