Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Окт. 30, 2024
Ferroptosis plays a vital role in the progression of various retinal diseases. The analysis mechanism cell ferroptosis has brought new targeted strategies for treating vascular diseases, degeneration and nerve is also major scientific issue field ferroptosis. In this review, we summarized results from currently available
Язык: Английский
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(22), С. 12340 - 12355
Опубликована: Май 22, 2024
Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function potentially triggering apoptosis or necrosis. This process is closely correlated with onset many diseases. Evidence suggests that phenolic hydroxyl groups food-borne plant polyphenols (FPPs) make them effective antioxidants capable preventing diseases triggered by membrane LP. Proper dietary intake FPPs can attenuate oxidative stress, especially damage phospholipids, activating Nrf2/GPx4 pathway. Nuclear factor E2-related 2 (Nrf2) an stress antagonist. The signaling pathway regulated Nrf2 a defense transduction organism against external stimuli such as reactive oxygen species exogenous chemicals. Glutathione peroxidase 4 (GPx4), under regulation Nrf2, only enzyme reduces lipid peroxides specificity, thus playing pivotal role regulating ferroptosis counteracting stress. study explored mechanism, antioxidant activity FPPs, mechanism It also highlighted bioprotective properties LP its associated mechanisms, including (i) activation pathway, GPx4 serving central target protein, (ii) activities, leading reduction production ROS other peroxides, (iii) effects on downstream phospholipid structure. In conclusion, play crucial natural However, further in-depth analysis coregulation multiple pathways required, combined these mechanisms need evaluation experimental models. Human trials could provide valuable insights into new directions for research application.
Язык: Английский
Процитировано
14
Drug Discovery Today, Год журнала: 2024, Номер 29(4), С. 103920 - 103920
Опубликована: Фев. 17, 2024
Язык: Английский
Процитировано
9
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Июнь 27, 2024
Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.
Язык: Английский
Процитировано
5
Cells, Год журнала: 2025, Номер 14(1), С. 49 - 49
Опубликована: Янв. 4, 2025
Retinitis pigmentosa (RP) is a hereditary disease characterized by progressive vision loss ultimately leading to blindness. This condition initiated mutations in genes expressed retinal cells, resulting the degeneration of rod photoreceptors, which subsequently followed cone photoreceptors. Mutations various retina are associated with RP. Among them, rhodopsin gene (RHO) most common cause this condition. Due involvement numerous and multiple single gene, RP highly heterogeneous making development effective treatments particularly challenging. The progression involves complex cellular responses restore homeostasis, including unfolded protein response (UPR) signaling, autophagy, cell death pathways. These mechanisms, however, often fail prevent photoreceptor degradation instead contribute under certain conditions. Current research focuses on pharmacological modulation components these pathways direct stabilization mutated receptors as potential treatment strategies. Despite efforts, intricate interplay between mechanisms diverse causative involved has hindered treatments. Advancing our understanding interactions specific genetic driving critical accelerate discovery therapeutic strategies for currently incurable disease.
Язык: Английский
Процитировано
0
Molecular Medicine, Год журнала: 2025, Номер 31(1)
Опубликована: Май 15, 2025
Abstract Background Retinal degeneration is a leading cause of blindness worldwide. The induction ferroptosis has been identified as an important mechanism contributing to the loss photoreceptors in retinal degeneration. Lipocalin-2 (LCN2) exhibits iron-regulatory properties and may modulate cell viability various diseases. However, effects LCN2 on remain unclear. Methods A light-induced injury model using 661W photoreceptor cells male rat were established. protein expression was assessed by western blotting. vitro investigated recombinant (rLCN2) small-interfering RNA (siRNA) targeting (siLCN2). Fe 2+ , malondialdehyde (MDA), tripeptide glutathione (GSH) levels, ferroptosis-associated proteins (solute carrier family 7 member 11 [SLC7A11] peroxidase-4 [GPX4]) measured. phosphokinase array blotting performed elucidate mechanisms underlying LCN2-modulated ferroptosis. Additionally, protective knockdown adeno-associated virus (AAV)-expressing short hairpin (shRNA) (AAV-shRNA-LCN2) structure function vivo evaluated hematoxylin eosin staining electroretinography. Results significantly upregulated following light exposure. Treatment with rLCN2 induced cells, shown decreased viability, increased inhibition SLC7A11 GPX4 expression, depletion GSH, enhanced MDA whereas siLCN2 protected against these effects. Exposure activated c-Jun N-terminal kinase (JNK), administration JNK inhibitor SP600125 from Lastly, AAV-shRNA-LCN2 inhibited retina, vivo. Conclusion key regulator modulating pathway. Therefore, presents new target for treatment
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Авг. 20, 2024
Hepatocellular carcinoma (HCC) is a highly aggressive cancer with poor prognosis. The molecular mechanisms underlying its development remain unclear. Recent studies have highlighted the crucial role of RNA modifications in HCC progression, which indicates their potential as therapeutic targets and biomarkers for managing HCC. In this review, we discuss functional through review summary relevant literature, to explore agents diagnostic prognostic This that specific modification pathways, such N6-methyladenosine, 5-methylcytosine, N7-methylguanosine, N1-methyladenosine, are erroneously regulated involved proliferation, autophagy, innate immunity, invasion, metastasis, immune cell infiltration, drug resistance These findings provide new perspective understanding HCC, well diagnosis treatment by targeting RNA-modifying enzymes or recognition proteins. More than ten regulators showed use diagnosis, prognosis decision utility Their application value necessitates extensive multi-center sample validation future. A growing number modifier inhibitors being developed, but lack preclinical experiments clinical poses significant obstacle, further research needed evaluate treatment. conclusion, provides an in-depth complex interplay between while emphasizing promising
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Окт. 30, 2024
Ferroptosis plays a vital role in the progression of various retinal diseases. The analysis mechanism cell ferroptosis has brought new targeted strategies for treating vascular diseases, degeneration and nerve is also major scientific issue field ferroptosis. In this review, we summarized results from currently available
Язык: Английский
Процитировано
0