Neurological mechanism-based analysis of the role and characteristics of physical activity in the improvement of depressive symptoms
Reviews in the Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Abstract
Depression
is
a
common
mental
disorder
characterized
by
high
prevalence
and
significant
adverse
effects,
making
the
searching
for
effective
interventions
an
urgent
priority.
In
recent
years,
physical
activity
(PA)
has
increasingly
been
recognized
as
standard
adjunctive
treatment
disorders
owing
to
its
low
cost,
easy
application,
efficiency.
Epidemiological
data
shows
positive
preventive
therapeutic
effects
of
PA
on
illnesses
such
depression.
This
article
systematically
describes
prophylactic
depression
biological
basis.
A
comprehensive
literature
analysis
reveals
that
significantly
improves
depressive
symptoms
upregulating
expression
“exerkines”
irisin,
adiponectin,
BDNF
positively
impacting
neuropsychiatric
conditions.
particular,
lactate
could
also
play
critical
role
in
ameliorating
due
findings
about
protein
lactylation
novel
post-transcriptional
modification.
The
suggests
terms
brain
structure,
may
improve
hippocampal
volume,
basal
ganglia
(neostriatum,
caudate-crustal
nucleus)
PFC
density
patients
with
MDD.
summary,
this
study
elucidates
multifaceted
potential
mechanisms
particular
emphasis
roles
various
exerkines.
Future
research
further
investigate
different
types,
intensities,
durations
depression,
well
how
better
integrate
into
existing
strategies
achieve
optimal
outcomes
health
interventions.
Язык: Английский
High-intensity training on CREB activation for improving brain health: a narrative review of possible molecular talks
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 20, 2025
Although
physical
exercise
has
obvious
benefits
in
brain
physiology,
the
molecular
biomarkers
induced
by
protocols
are
inconclusive.
Evidence
indicates
that
interventions
effective
shaping
physiology.
However,
potential
mediator
for
improving
functions
is
uncertain.
CREB
one
of
targets
triggers
various
cross-talk
to
improve
neurogenesis,
long-term
potentiation,
and
synaptogenesis.
Therefore,
may
be
situated
on
causal
path
between
maintaining
health
exercising.
To
support
this,
studies
have
shown
exercise-mediated
phosphorylation
improves
cognitive
memory.
In
addition,
among
(types,
duration,
frequency),
intensity
been
reported
most
triggering
CREB-mediated
signaling.
For
example,
HIT
increases
synthesis
CREB,
which
not
only
induce
physiology
but
also
pathology
higher
activation
its
downstream
targets,
such
as
BDNF.
this
review
aims
understand
effects
function
how
can
mediate
CREB-induced
health.
Язык: Английский
Exercise-induced neuroplasticity: a new perspective on rehabilitation for chronic low back pain
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Июнь 7, 2024
Chronic
low
back
pain
patients
often
experience
recurrent
episodes
due
to
various
peripheral
and
central
factors,
leading
physical
mental
impairments,
affecting
their
daily
life
work,
increasing
the
healthcare
burden.
With
continuous
advancement
of
neuropathological
research,
changes
in
brain
structure
function
chronic
have
been
revealed.
Neuroplasticity
is
an
important
mechanism
self-regulation
plays
a
key
role
neural
injury
repair.
Targeting
neuroplasticity
regulating
nervous
system
improve
functional
impairments
has
become
research
focus
rehabilitation
medicine.
Recent
studies
shown
that
exercise
can
beneficial
effects
on
body,
such
as
improving
cognition,
combating
depression,
enhancing
athletic
performance.
Exercise-induced
may
be
potential
through
which
affects
brain.
This
article
systematically
introduces
theory
exercise-induced
neuroplasticity,
explores
with
pain,
further
looks
forward
new
directions
targeted
neuroplasticity-based
treatment
for
pain.
Язык: Английский
Lactate modulates microglial inflammatory responses through HIF-1α-mediated CCL7 signaling after cerebral ischemia in mice
International Immunopharmacology,
Год журнала:
2024,
Номер
146, С. 113801 - 113801
Опубликована: Дек. 15, 2024
Язык: Английский
Cognitive and sensorimotor benefits of moderate- and high-intensity exercise are associated with specific expression of neurotrophic markers in older rats
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 21, 2025
Язык: Английский
The hypothalamic estrogen receptor α pathway is involved in high-intensity interval training-induced visceral fat loss in premenopausal rats
Lipids in Health and Disease,
Год журнала:
2025,
Номер
24(1)
Опубликована: Март 27, 2025
Visceral
adipose
tissue
(VAT)
is
strongly
associated
with
metabolic
diseases.
Both
high-intensity
interval
training
(HIT)
and
moderate-intensity
(MIT)
reduce
VAT
effectively;
however,
HIT
might
mediate
greater
loss
in
females.
The
estrogen
receptor
α
(ERα)
pathway
may
play
a
key
role.
aim
of
the
present
study
was
to
confirm
role
adipose/hypothalamic
ERα
HIT/MIT-mediated
loss,
as
well
hypothalamic
electrophysiology
body
catabolism
changes
pre-
post-menopausal
animal
models.
Ovariectomy
(OVX)
or
sham
surgeries
were
conducted
establish
pre/postmenopausal
female
rat
After
distance-matched
long-term
MIT
interventions,
expression
hypothalamic/VAT,
food
intake,
spontaneous
physical
activity
(SPA),
mass
morphology,
local
field
potential
(LFPs)
paraventricular
nuclei
(PVN)
excessive
post-exercise
oxygen
consumption
(EPOC),
observed.
A
target
chemical
block
during
recovery
period
executed
further
verify
pathway.
enhanced
hypothalamus
rather
than
pre-,
but
not
postmenopausal
group,
which
accompanied
by
elevated
LFP
power
density
β
bands,
EPOC
larger
MIT.
Chemical
blockade
suppressed
mediated
HIT.
During
period,
involved
induced
elevation
reduction
premenopausal
rats.
Язык: Английский
Lactylation: A Novel Epigenetic Regulator of Cellular Senescence
Aging and Disease,
Год журнала:
2025,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2025
Cellular
senescence
is
the
basic
unit
of
organismal
aging,
a
complicated
biological
process
involving
several
cell
types
and
tissues.
It
also
an
important
mechanism
by
which
body
responds
to
damage
potential
carcinogenesis.
However,
excessive
or
abnormal
cellular
can
lead
tissue
functional
degradation
occurrence
diseases.
In
recent
years,
role
epigenetic
modifications
in
has
received
extensive
attention.
Lactylation,
novel
post-translational
modification
derived
from
lactate,
recently
gained
significant
attention
as
key
factor
metabolism
regulation,
gradually
demonstrating
its
importance
regulation
senescence.
This
review
emphasizes
bidirectional
causal
relationship
between
lactylation
senescence,
highlighting
therapeutic
target
for
aging-related
Язык: Английский
The role of protein lactylation in brain health and disease: current advances and future directions
Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Апрель 30, 2025
Lactate,
the
end
product
of
glycolysis,
plays
a
crucial
role
in
cellular
signaling
and
metabolism.
The
discovery
lactylation,
novel
post-translational
modification,
has
uncovered
lactate
regulating
diseases,
especially
brain.
Lactylation
connects
genetic
encoding
with
protein
function,
thereby
influencing
key
biological
processes.
Increasing
evidence
supports
lactate-mediated
lactylation
as
critical
modulator
neurological
disorders.
This
review
offers
an
overview
metabolism
highlighting
recent
advances
understanding
regulatory
enzymes
their
central
nervous
system.
We
investigate
impact
on
brain
dysfunctions,
including
neurodegenerative
cerebrovascular
disorders,
neuroinflammation,
tumors,
psychiatric
conditions.
Moreover,
we
highlight
therapeutic
potential
targeting
treating
disorders
outline
research
gaps
future
directions
needed
to
advance
this
promising
field.
Язык: Английский
Peroxidase-like Nanoparticles of Noble Metals Stimulate Increasing Sensitivity of Flavocytochrome b2-Based L-Lactate Biosensors
Biosensors,
Год журнала:
2024,
Номер
14(11), С. 562 - 562
Опубликована: Ноя. 20, 2024
We
report
the
development
of
amperometric
biosensors
(ABSs)
employing
flavocytochrome
Язык: Английский
Muscle–brain crosstalk mediated by exercise-induced myokines - insights from experimental studies
Frontiers in Physiology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 2, 2024
Over
the
past
couple
of
decades,
it
has
become
apparent
that
skeletal
muscles
might
be
engaged
in
endocrine
signaling,
mostly
as
a
result
exercise
or
physical
activity
general.
The
importance
this
phenomenon
is
currently
studied
terms
impact
exercise-
-induced
signaling
factors
have,
interaction
"muscle-brain
crosstalk."
So
far,
muscle-derived
myokines
were
demonstrated
to
intercede
connection
between
and
plethora
various
organs
such
adipose
tissue,
liver,
pancreas.
However,
exact
mechanism
muscle-brain
communication
yet
determined.
It
speculated
that,
particular,
brain-derived
neurotrophic
factor
(BDNF),
irisin,
cathepsin
B
(CTSB),
interleukin
6
(IL-6),
insulin-like
growth
factor-1
(IGF-1)
partake
crosstalk
by
promoting
neuronal
proliferation
synaptic
plasticity,
also
resulting
improved
cognition
ameliorated
behavioral
alterations.
Researchers
suggest
act
directly
on
brain
parenchyma
via
crossing
blood-brain
barrier
(BBB).
following
article
reviews
information
available
regarding
rodent
studies
main
determined
cross
BBB,
specifically
addressing
association
exercise-induced
myokine
release
central
nervous
system
(CNS)
impairments.
Although
hypothesis
being
critical
sources
seems
promising,
should
not
forgotten
origin
these
vary,
depending
cell
types
their
synthesis.
Limited
amount
research
providing
alterations
expression
at
same
time,
results
taking
them
only
circumstantial
evidence
way
determine
actual
involvement
overall
state
homeostasis.
CNS
Язык: Английский