Muscle–brain crosstalk mediated by exercise-induced myokines - insights from experimental studies DOI Creative Commons

Magdalena Kostka,

Julia Morys, Andrzej Małecki

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Over the past couple of decades, it has become apparent that skeletal muscles might be engaged in endocrine signaling, mostly as a result exercise or physical activity general. The importance this phenomenon is currently studied terms impact exercise- -induced signaling factors have, interaction "muscle-brain crosstalk." So far, muscle-derived myokines were demonstrated to intercede connection between and plethora various organs such adipose tissue, liver, pancreas. However, exact mechanism muscle-brain communication yet determined. It speculated that, particular, brain-derived neurotrophic factor (BDNF), irisin, cathepsin B (CTSB), interleukin 6 (IL-6), insulin-like growth factor-1 (IGF-1) partake crosstalk by promoting neuronal proliferation synaptic plasticity, also resulting improved cognition ameliorated behavioral alterations. Researchers suggest act directly on brain parenchyma via crossing blood-brain barrier (BBB). following article reviews information available regarding rodent studies main determined cross BBB, specifically addressing association exercise-induced myokine release central nervous system (CNS) impairments. Although hypothesis being critical sources seems promising, should not forgotten origin these vary, depending cell types their synthesis. Limited amount research providing alterations expression at same time, results taking them only circumstantial evidence way determine actual involvement overall state homeostasis. CNS

Language: Английский

Neurological mechanism-based analysis of the role and characteristics of physical activity in the improvement of depressive symptoms DOI
Nan Wang, Shanshan Zhu, Shuyang Chen

et al.

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Depression is a common mental disorder characterized by high prevalence and significant adverse effects, making the searching for effective interventions an urgent priority. In recent years, physical activity (PA) has increasingly been recognized as standard adjunctive treatment disorders owing to its low cost, easy application, efficiency. Epidemiological data shows positive preventive therapeutic effects of PA on illnesses such depression. This article systematically describes prophylactic depression biological basis. A comprehensive literature analysis reveals that significantly improves depressive symptoms upregulating expression “exerkines” irisin, adiponectin, BDNF positively impacting neuropsychiatric conditions. particular, lactate could also play critical role in ameliorating due findings about protein lactylation novel post-transcriptional modification. The suggests terms brain structure, may improve hippocampal volume, basal ganglia (neostriatum, caudate-crustal nucleus) PFC density patients with MDD. summary, this study elucidates multifaceted potential mechanisms particular emphasis roles various exerkines. Future research further investigate different types, intensities, durations depression, well how better integrate into existing strategies achieve optimal outcomes health interventions.

Language: Английский

Citations

1
High-intensity training on CREB activation for improving brain health: a narrative review of possible molecular talks DOI Creative Commons
Ping Li,

Yan Hu,

Liqi Tong

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Although physical exercise has obvious benefits in brain physiology, the molecular biomarkers induced by protocols are inconclusive. Evidence indicates that interventions effective shaping physiology. However, potential mediator for improving functions is uncertain. CREB one of targets triggers various cross-talk to improve neurogenesis, long-term potentiation, and synaptogenesis. Therefore, may be situated on causal path between maintaining health exercising. To support this, studies have shown exercise-mediated phosphorylation improves cognitive memory. In addition, among (types, duration, frequency), intensity been reported most triggering CREB-mediated signaling. For example, HIT increases synthesis CREB, which not only induce physiology but also pathology higher activation its downstream targets, such as BDNF. this review aims understand effects function how can mediate CREB-induced health.

Language: Английский

Citations

1
Exercise-induced neuroplasticity: a new perspective on rehabilitation for chronic low back pain DOI Creative Commons

Jianpeng Zou,

Shijie Hao

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: June 7, 2024

Chronic low back pain patients often experience recurrent episodes due to various peripheral and central factors, leading physical mental impairments, affecting their daily life work, increasing the healthcare burden. With continuous advancement of neuropathological research, changes in brain structure function chronic have been revealed. Neuroplasticity is an important mechanism self-regulation plays a key role neural injury repair. Targeting neuroplasticity regulating nervous system improve functional impairments has become research focus rehabilitation medicine. Recent studies shown that exercise can beneficial effects on body, such as improving cognition, combating depression, enhancing athletic performance. Exercise-induced may be potential through which affects brain. This article systematically introduces theory exercise-induced neuroplasticity, explores with pain, further looks forward new directions targeted neuroplasticity-based treatment for pain.

Language: Английский

Citations

4
Lactate modulates microglial inflammatory responses through HIF-1α-mediated CCL7 signaling after cerebral ischemia in mice DOI
Yuanyuan Zhang, Shuyue Zhang, Liufei Yang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113801 - 113801

Published: Dec. 15, 2024

Language: Английский

Citations

4
Cognitive and sensorimotor benefits of moderate- and high-intensity exercise are associated with specific expression of neurotrophic markers in older rats DOI Creative Commons

Cécile Marcourt,

Caroline Pin-Barre,

Antoine Langeard

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 21, 2025

Language: Английский

Citations

0
The hypothalamic estrogen receptor α pathway is involved in high-intensity interval training-induced visceral fat loss in premenopausal rats DOI Creative Commons
Juanjuan Wang,

Shuai Tian,

Juan Du

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 27, 2025

Visceral adipose tissue (VAT) is strongly associated with metabolic diseases. Both high-intensity interval training (HIT) and moderate-intensity (MIT) reduce VAT effectively; however, HIT might mediate greater loss in females. The estrogen receptor α (ERα) pathway may play a key role. aim of the present study was to confirm role adipose/hypothalamic ERα HIT/MIT-mediated loss, as well hypothalamic electrophysiology body catabolism changes pre- post-menopausal animal models. Ovariectomy (OVX) or sham surgeries were conducted establish pre/postmenopausal female rat After distance-matched long-term MIT interventions, expression hypothalamic/VAT, food intake, spontaneous physical activity (SPA), mass morphology, local field potential (LFPs) paraventricular nuclei (PVN) excessive post-exercise oxygen consumption (EPOC), observed. A target chemical block during recovery period executed further verify pathway. enhanced hypothalamus rather than pre-, but not postmenopausal group, which accompanied by elevated LFP power density β bands, EPOC larger MIT. Chemical blockade suppressed mediated HIT. During period, involved induced elevation reduction premenopausal rats.

Language: Английский

Citations

0
Lactylation: A Novel Epigenetic Regulator of Cellular Senescence DOI Creative Commons
Caiyu Sun, Jiaxuan Li, Lei Dong

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Cellular senescence is the basic unit of organismal aging, a complicated biological process involving several cell types and tissues. It also an important mechanism by which body responds to damage potential carcinogenesis. However, excessive or abnormal cellular can lead tissue functional degradation occurrence diseases. In recent years, role epigenetic modifications in has received extensive attention. Lactylation, novel post-translational modification derived from lactate, recently gained significant attention as key factor metabolism regulation, gradually demonstrating its importance regulation senescence. This review emphasizes bidirectional causal relationship between lactylation senescence, highlighting therapeutic target for aging-related

Language: Английский

Citations

0
The role of protein lactylation in brain health and disease: current advances and future directions DOI Creative Commons

M.E. Han,

Wenfeng He, Wengen Zhu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 30, 2025

Lactate, the end product of glycolysis, plays a crucial role in cellular signaling and metabolism. The discovery lactylation, novel post-translational modification, has uncovered lactate regulating diseases, especially brain. Lactylation connects genetic encoding with protein function, thereby influencing key biological processes. Increasing evidence supports lactate-mediated lactylation as critical modulator neurological disorders. This review offers an overview metabolism highlighting recent advances understanding regulatory enzymes their central nervous system. We investigate impact on brain dysfunctions, including neurodegenerative cerebrovascular disorders, neuroinflammation, tumors, psychiatric conditions. Moreover, we highlight therapeutic potential targeting treating disorders outline research gaps future directions needed to advance this promising field.

Language: Английский

Citations

0
Peroxidase-like Nanoparticles of Noble Metals Stimulate Increasing Sensitivity of Flavocytochrome b2-Based L-Lactate Biosensors DOI Creative Commons
Galina Gayda, Olha Demkiv, Nataliya Stasyuk

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(11), P. 562 - 562

Published: Nov. 20, 2024

We report the development of amperometric biosensors (ABSs) employing flavocytochrome

Language: Английский

Citations

1
Muscle–brain crosstalk mediated by exercise-induced myokines - insights from experimental studies DOI Creative Commons

Magdalena Kostka,

Julia Morys, Andrzej Małecki

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Over the past couple of decades, it has become apparent that skeletal muscles might be engaged in endocrine signaling, mostly as a result exercise or physical activity general. The importance this phenomenon is currently studied terms impact exercise- -induced signaling factors have, interaction "muscle-brain crosstalk." So far, muscle-derived myokines were demonstrated to intercede connection between and plethora various organs such adipose tissue, liver, pancreas. However, exact mechanism muscle-brain communication yet determined. It speculated that, particular, brain-derived neurotrophic factor (BDNF), irisin, cathepsin B (CTSB), interleukin 6 (IL-6), insulin-like growth factor-1 (IGF-1) partake crosstalk by promoting neuronal proliferation synaptic plasticity, also resulting improved cognition ameliorated behavioral alterations. Researchers suggest act directly on brain parenchyma via crossing blood-brain barrier (BBB). following article reviews information available regarding rodent studies main determined cross BBB, specifically addressing association exercise-induced myokine release central nervous system (CNS) impairments. Although hypothesis being critical sources seems promising, should not forgotten origin these vary, depending cell types their synthesis. Limited amount research providing alterations expression at same time, results taking them only circumstantial evidence way determine actual involvement overall state homeostasis. CNS

Language: Английский

Citations

1