Food Bioactives as a Novel Source for Nutraceuticals

Опубликована: Янв. 1, 2025

Язык: Английский

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KEAP1‐NRF2/HO‐1 Pathway Promotes Ferroptosis and Neuronal Injury in Schizophrenia

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Фев. 28, 2025

ABSTRACT Background This study investigates the role of KEAP1‐NRF2/HO‐1 signaling pathway in inducing ferroptosis and contributing to neuronal damage schizophrenia. Methods We retrieved schizophrenia‐related data ferroptosis‐related genes from RNA microarray dataset GSE27383 FerrDB database, respectively. Bioinformatics identified KEAP1 as a downregulated gene, which was validated using qRT‐PCR Western blot. assessed intracellular Fe 2 ⁺ content, MDA levels, GSH, GPX4 prefrontal cortex peripheral blood mononuclear cells (PBMCs) patients with Cortical interneurons (cINs) were generated human‐induced pluripotent stem (hiPSCs) schizophrenia used explore alterations during neurodevelopment. In addition, overexpression induced cINs via transfection pcDNA KEAP1. The Fe⁺ oxidative stress indicators, lipid peroxidation, inflammatory cytokines measured after transfection. To investigate molecular mechanisms, KI696—a high‐affinity probe that disrupts KEAP1–NRF2 interaction—was applied, changes stress, peroxidation (C11‐BODIPY staining), iron metabolism, pathways evaluated. Results Patients exhibited underexpression KEAP1, key regulator ferroptosis, along elevated levels increased concentrations, indicating enhanced stress. Reduced activity GSH also observed, suggesting an susceptibility ferroptosis. further this, derived hiPSCs studied. These showed decreased expression. Overexpression led reduction concentrations damage, highlighting KEAP1's regulatory treatment KI696 significant related antioxidant defenses, inflammation. Conclusion Our findings indicate contributes injury

Язык: Английский

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Potential therapeutic targets for Alzheimer’s disease: Fibroblast growth factors and their regulation of ferroptosis, pyroptosis and autophagy

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Strategies to Counteract Oxidative Stress and Inflammation in Chronic-Degenerative Diseases 2.0

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 5026 - 5026

Опубликована: Май 4, 2024

Oxidative stress and inflammation are recognized as pivotal contributors common features of several chronic degenerative diseases, including cancer, metabolic syndrome, type 2 diabetes, cardiovascular diseases neurodegenerative disorders, affecting a high percentage the population [...]

Язык: Английский

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Sex-Biased Associations of Circulating Ferroptosis Inhibitors with Reduced Lipid Peroxidation and Better Neurocognitive Performance in People with HIV

Опубликована: Авг. 24, 2024

Ferroptosis is implicated in viral neuropathogenesis and may underlie HIV-associated neurocognitive impairment (NCI). Emerging data also suggest differences brain iron transport by sex. We hypothesized that circulating ferritins inhibit ferroptosis associate with function NCI people HIV (PWH) a sex-biased manner. Serum ferritin heavy-chain-1 (Fth-1), light-chain (Ftl), urinary F2-isoprostanes (uF2-isoPs, specific lipid peroxidation marker) were quantified 324 PWH (including 61 women) serial global (NPZ4) domain-specific testing. Biomarker associations test scores evaluated multivariable regression; correlations uF2-isoPs assessed. Higher Ftl Fth-1 associated less all (adjusted odds ratios 0.53, 95% Confidence Interval (95% CI) 0.36-0.79 0.66, CI 0.45-0.97, respectively). In women, higher better NPZ-4 (Ftl: adjusted beta (β)=0.15, 0.02-0.29; Ftl-by-sex βinteraction=0.32, p=0.047) scores. Effects on performance persisted for up to 5 years. Levels of both correlated inversely women rho=-0.47, p<0.001). Circulating exert sustained, neuroprotective effects PWH, possibly protecting against iron-mediated (ferroptosis). Larger studies are needed confirm the observed sex further delineate underlying mechanisms.

Язык: Английский

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Isobicyclogermacrenal ameliorates hippocampal ferroptosis involvement in neurochemical disruptions and neuroinflammation induced by sleep deprivation in rats

Phytomedicine, Год журнала: 2024, Номер 136, С. 156306 - 156306

Опубликована: Ноя. 29, 2024

Язык: Английский

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Sex-Biased Associations of Circulating Ferroptosis Inhibitors with Reduced Lipid Peroxidation and Better Neurocognitive Performance in People with HIV

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1042 - 1042

Опубликована: Авг. 28, 2024

Ferroptosis is implicated in viral neuropathogenesis and may underlie HIV-associated neurocognitive impairment (NCI). Emerging data also suggest differences brain iron transport by sex. We hypothesized that circulating ferritins inhibit ferroptosis associate with function NCI people HIV (PWH) a sex-biased manner. Serum ferritin heavy-chain-1 (FTH1), light-chain (FTL), urinary F2-isoprostanes (uF2-isoPs, specific lipid peroxidation marker) were quantified 324 PWH (including 61 women) serial global (NPZ-4) domain-specific testing. Biomarker associations test scores NCIs evaluated multivariable regression; correlations uF2-isoPs assessed. Higher FTL FTH1 levels associated less all (adjusted odds ratios 0.53, 95% confidence interval (95% CI) 0.36–0.79 0.66, CI 0.45–0.97, respectively). In women, higher better NPZ-4 (FTL adjusted beta (β) = 0.15, 0.02–0.29; FTL-by-sex βinteraction 0.32, p 0.047) scores. Effects on performance persisted for up to 5 years. Levels of both correlated inversely women (FTL: rho −0.47, < 0.001). Circulating exert sustained, neuroprotective effects PWH, possibly protecting against iron-mediated (ferroptosis). Larger studies are needed confirm the observed sex further delineate underlying mechanisms.

Язык: Английский

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The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 8, 2024

Stroke ranks as the second most significant contributor to mortality worldwide and is a major factor in disability. Ischemic strokes account for 71% of all stroke incidences globally. The foremost approach treating ischemic prioritizes quick reperfusion, involving methods such intravenous thrombolysis endovascular thrombectomy. These techniques can reduce disability but necessitate immediate intervention. After cerebral ischemia, inflammation rapidly arises vascular system, producing pro-inflammatory signals that activate immune cells, which turn worsen neuronal injury. Following an overload intracellular iron triggers Fenton reaction, resulting excess free radicals cause lipid peroxidation damage cellular membranes, ultimately leading ferroptosis. relationship between ferroptosis increasingly recognized vital process ischemia-reperfusion (I/R). Inflammatory processes disturb balance encourage (LPO) through neuroglial while also reducing activity antioxidant systems, contributing Furthermore, products generated during ferroptosis, along with damage-associated molecular patterns (DAMPs) released from ruptured cell incite inflammation. Given complex inflammation, investigating their interaction brain I/R crucial understanding disease development creating innovative therapeutic options. Consequently, this article will provide comprehensive introduction mechanisms linking neuroinflammation, well evaluate potential treatment modalities, goal presenting various insights alleviating injury exploring new avenues.

Язык: Английский

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Mitochondrial fatty acid oxidase CPT1A ameliorates postoperative cognitive dysfunction by regulating astrocyte ferroptosis

Brain Research, Год журнала: 2024, Номер unknown, С. 149424 - 149424

Опубликована: Дек. 1, 2024

Язык: Английский

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Pharmacological activities and therapeutic potential of Hyperoside in the treatment of Alzheimer’s and Parkinson’s diseases: A systemic review

Neuroscience, Год журнала: 2024, Номер 563, С. 136 - 147

Опубликована: Ноя. 1, 2024

Язык: Английский

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