Biology, Год журнала: 2024, Номер 13(9), С. 714 - 714
Опубликована: Сен. 11, 2024
Recent studies have established associations between the gut microbiota (GM) and thyroid diseases (TDs). However, their causal relationships remain elusive.
Язык: Английский
Autoimmunity Reviews, Год журнала: 2025, Номер unknown, С. 103780 - 103780
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 735, С. 150831 - 150831
Опубликована: Окт. 13, 2024
Язык: Английский
Процитировано
2
Medicine, Год журнала: 2024, Номер 103(32), С. e39247 - e39247
Опубликована: Авг. 9, 2024
Recent scientific research has verified a link between malignant tumors in the stomach and gut microbiota. This employed Mendelian randomization (MR) techniques to explore association microbiota benign gastric malignancies. The data were derived from genome wide studies-aggregated consisting of 211 microbes lesions analyzed by MR. Five statistical tools, including inverse variance weighting, weighted median, MR-Egger, simple mode, analysis. utilization leave-one-out approach served as an effective means detecting outliers. Furthermore, implementing Randomization Pleiotropy RESidual Sum Outlier (MR-PRESSO) MR-Egger intercepts was mitigate impact horizontal pleiotropy. Cochran Q scores for weighting utilized determine extent heterogeneity. findings indicate that family Porphyromonadaceae (odds ratio [OR] = 2.185, 95% confidence interval [CI]: 1.239-3.855, P .007), class Bacilli (OR 1.556, 95%CI: 1.091 - 2.220, .015), Lactobacillaceae 1.437, 1.049 1.969, .024), Oxalobacteraceae 1.290, 1.035 1.608, .023) are positively associated with occurrence tumors. Conversely, Pasteurellaceae 0.752, 0.566 0.999, .049) Peptococcaceae 0.622, 0.425 0.908, .014) exhibit protective effect significantly decrease likelihood this study suggest probability developing is presence Porphyromonadaceae, Bacilli, Oxalobacteraceae, In contrast, negatively risk. Therefore, regulating may be potential strategy reduce incidence
Язык: Английский
Процитировано
1
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Дек. 24, 2024
This review synthesizes key findings from the past five years of experimental literature, elucidating gut microbiome’s significant influence on pathogenesis thyroid diseases. A pronounced shift in microbiota composition has been consistently observed, with a reduction bacteria such as Bifidobacterium , Bacillaceae Megamonas and Clostridium notable increase bacteria, including Bacteroides Proteobacteria Actinobacteria Desulfobacterota Klebsiella . These alterations are implicated development progression diseases by impacting metabolic pathways bile acid cytokine production, decrease short-chain fatty acids (SCFAs) that crucial for immune regulation hormone homeostasis. The also highlights therapeutic implications probiotics managing conditions. Evidence suggests probiotic adjunct therapy can modulate microbiota, leading to improvements function patient outcomes. use specific strains, Lactiplantibacillus plantarum 299v longum demonstrated potential enhancing effects traditional treatments possibly restoring balanced microbiota. Notably, fecal transplantation (FMT) emerged promising intervention Graves’ Disease (GD), demonstrating recalibrate thereby influencing neurotransmitters trace elements via gut-brain gut-thyroid axes. integration microbiome-based therapies is anticipated usher new era personalized disease management, offering more nuanced approach care. By integrating this body work, offers an innovative perspective broad impact applications probiotics.
Язык: Английский
Процитировано
0
Biology, Год журнала: 2024, Номер 13(9), С. 714 - 714
Опубликована: Сен. 11, 2024
Recent studies have established associations between the gut microbiota (GM) and thyroid diseases (TDs). However, their causal relationships remain elusive.
Язык: Английский
Процитировано
0