Altered Mitochondrial Function in MASLD: Key Features and Promising Therapeutic Approaches
Antioxidants,
Год журнала:
2024,
Номер
13(8), С. 906 - 906
Опубликована: Июль 26, 2024
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD),
formerly
known
as
nonalcoholic
fatty
(NAFLD),
encompasses
a
range
of
conditions
from
steatosis
to
steatohepatitis
(NASH).
Its
prevalence,
especially
among
patients
with
metabolic
syndrome,
highlights
its
growing
global
impact.
The
pathogenesis
MASLD
involves
dysregulation,
inflammation,
oxidative
stress,
genetic
factors
and,
notably,
mitochondrial
dysfunction.
Recent
studies
underscore
the
critical
role
dysfunction
in
MASLD's
progression.
Therapeutically,
enhancing
function
has
gained
interest,
along
lifestyle
changes
and
pharmacological
interventions
targeting
processes.
FDA's
approval
resmetirom
for
metabolic-associated
(MASH)
fibrosis
marks
significant
step.
While
represents
progress,
further
research
is
essential
understand
MASLD-related
fully.
Innovative
strategies
like
gene
editing
small-molecule
modulators,
alongside
interventions,
can
potentially
improve
treatment.
Drug
repurposing
new
targets
will
advance
therapy,
addressing
increasing
burden.
Therefore,
this
review
aims
provide
better
understanding
identify
more
effective
preventive
treatment
strategies.
Язык: Английский
Zn2+ protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation
Cellular Signalling,
Год журнала:
2025,
Номер
unknown, С. 111629 - 111629
Опубликована: Янв. 1, 2025
Язык: Английский
Klotho in age-related cardiovascular diseases: Insights into mitochondrial dysfunction and cell death
IJC Heart & Vasculature,
Год журнала:
2025,
Номер
57, С. 101629 - 101629
Опубликована: Март 8, 2025
Язык: Английский
Mitochondrial transplantation combined with mitoquinone and melatonin: A survival strategy against myocardial reperfusion injury in aged rats
Experimental Physiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
Abstract
Myocardial
ischaemia–reperfusion
(IR)
injury
poses
a
severe
threat
to
cardiac
health,
particularly
in
the
ageing
population,
where
susceptibility
such
damage
is
significantly
heightened
owing
age‐related
declines
mitochondrial
function,
thus
highlighting
mitochondria
as
crucial
targets
for
innovative
therapies.
The
aim
of
this
study
was
investigate
combined
modality
therapy
involving
transplantation
and
boosters
mitoquinone
melatonin
address
myocardial
IR
aged
rats.
A
total
54
male
Wistar
rats,
22–24
months,
were
randomly
divided
into
groups
that
either
received
or
not,
subjected
various
treatments,
both
individually
combination.
induced
by
temporarily
blocking
reopening
left
anterior
descending
coronary
artery.
Mitoquinone
given
intraperitoneally
14
days
prior
ischaemia,
while
isolated
administered
intramyocardially,
respectively,
at
onset
reperfusion.
Finally,
we
evaluated
changes
haemodynamic
indices,
creatine
kinase‐MB
levels,
function
endpoints
expression
biogenesis
genes,
including
sirtuin
1
(
SIRT‐1
),
peroxisome
proliferator‐activated
receptor
gamma
coactivator
1‐alpha
PGC‐1α
)
nuclear
respiratory
factor
2
NRF‐2
).
triple
enhanced
decreased
levels
improved
along
with
genes
This
approach
elicited
significant
cardioprotection
comparison
single
dual
provided
substantial
rat
hearts
improving
through
/
profiles,
suggesting
promising
strategy
mitigating
elderly
patients.
Язык: Английский
Advances in α-Lipoic Acid for Disease Prevention: Mechanisms and Therapeutic Insights
Molecules,
Год журнала:
2025,
Номер
30(9), С. 1972 - 1972
Опубликована: Апрель 29, 2025
α-Lipoic
acid
(ALA)
is
a
naturally
occurring
compound
with
diverse
biological
functions,
widely
distributed
in
animal
and
plant
tissues.
It
has
attracted
considerable
attention
due
to
its
versatile
therapeutic
potential.
However,
despite
these
promising
prospects,
the
clinical
application
of
ALA
remains
limited
by
low
bioavailability
chemical
instability
an
incomplete
understanding
multifaceted
mechanisms
across
various
diseases.
This
review
provides
comprehensive
overview
biochemical
properties
ALA,
including
direct
free-radical-scavenging
activity,
regeneration
endogenous
antioxidants,
chelation
metal
ions,
modulation
inflammatory
responses.
We
also
highlight
current
evidence
regarding
ALA’s
roles
efficacy
major
diseases,
such
as
neurodegenerative
disorders,
lung
cardiovascular
diabetes.
Furthermore,
recent
advancements
innovative
strategies
ALA-based
derivatives
drug-delivery
systems
are
summarized,
emphasizing
their
potential
address
complex
diseases
necessity
for
further
translational
studies.
aims
provide
theoretical
foundation
rational
design
therapies,
thereby
supporting
future
applications
optimization
strategies.
Язык: Английский
Impact of plant-derived antioxidants on heart aging: a mechanistic outlook
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 21, 2025
Heart
aging
involves
a
complex
interplay
of
genetic
and
environmental
influences,
leading
to
gradual
deterioration
cardiovascular
integrity
function.
Age-related
physiological
changes,
including
ventricular
hypertrophy,
diastolic
dysfunction,
myocardial
fibrosis,
increased
arterial
stiffness,
endothelial
are
influenced
by
key
mechanisms
like
autophagy,
inflammation,
oxidative
stress.
This
review
aims
explore
the
therapeutic
potential
plant-derived
bioactive
antioxidants
in
mitigating
heart
aging.
These
compounds,
often
rich
polyphenols,
flavonoids,
other
phytochemicals,
exhibit
notable
antioxidant,
anti-inflammatory,
cardioprotective
properties.
substances
have
intricate
properties,
ability
scavenge
ROS,
enhance
endogenous
antioxidant
defenses,
regulate
signaling
pathways,
impede
fibrosis
inflammation-promoting
processes.
By
focusing
on
molecular
linked
cardiac
aging,
produced
from
plants
provide
significant
promise
reduce
age-related
decline
improve
general
health.
Through
comprehensive
analysis
preclinical
clinical
studies,
this
work
highlights
associated
with
promising
effects
antioxidants.
The
findings
may
helpful
for
researchers
identifying
specific
molecules
preventive
heart.
Язык: Английский
Mechanisms and Therapeutic Strategies for Myocardial Ischemia-Reperfusion Injury in Diabetic States
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
7(12), С. 3691 - 3717
Опубликована: Ноя. 1, 2024
In
patients
with
myocardial
infarction,
one
of
the
complications
that
may
occur
after
revascularization
is
ischemia-reperfusion
injury
(IRI),
characterized
by
a
depleted
oxygen
supply
and
absence
blood
flow
recovery
reperfusion,
leading
to
expansion
poor
healing
infarction
reversal
left
ventricular
remodeling,
an
increase
in
risk
for
major
adverse
cardiovascular
events
such
as
heart
failure,
arrhythmia,
cardiac
cell
death.
As
factor
disease,
diabetes
mellitus
increases
susceptibility
IRI
through
various
mechanisms,
acute
incidence,
decreases
responsiveness
protective
strategies
efficacy
methods,
mortality
infarction.
This
Review
summarizes
existing
therapeutic
strategies,
potential
targets
diabetic
states,
which
has
very
compelling
clinical
significance.
Язык: Английский
Synergistic Protection of Vitamin B Complex and Alpha-Lipoic Acid Against Hepatic Ischemia–Reperfusion Injury: Boosting Antioxidant Defenses in Rats
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(12), С. 13554 - 13564
Опубликована: Ноя. 28, 2024
This
study
aimed
to
investigate
the
protective
effects
of
vitamin
B
complex
and
alpha-lipoic
acid
(ALA)
pre-treatments
on
hepatic
ischemia–reperfusion
injury
(IRI)
in
rats,
focusing
their
potential
enhance
antioxidant
defense
mechanisms
reduce
post-ischemic
liver
damage.
Thirty
male
Wistar
albino
rats
were
divided
into
four
groups:
sham
group
(n
=
10),
IRI
+
ALA
10).
In
IRI,
B,
groups,
underwent
45
min
ischemia
followed
by
60
reperfusion.
Serum
levels
aspartate
aminotransferase
(AST),
alanine
(ALT),
urea,
creatinine,
lactate
dehydrogenase
(LDH)
measured.
Additionally,
serum
total
status
(TAS)
oxidant
(TOS)
assessed,
oxidative
stress
index
(OSI)
was
calculated.
Liver
tissue
samples
collected
for
morphological
evaluation.
ALT,
AST,
creatinine
LDH
better
compared
with
but
difference
statistically
significant
only
(p
<
0.05).
The
lowest
TOS
OSI
reported
groups
these
had
significantly
higher
TAS
Our
findings
suggest
that
a
alone
or
combination
reduces
enhancing
anti-oxidative
status.
low
dose
may
be
co-factor
results
studies
larger
doses
are
required
determine
its
liver.
Язык: Английский
Immunometabolism in the Aging Heart
Journal of the American Heart Association,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Structural,
functional,
and
molecular-level
changes
in
the
aging
heart
are
influenced
by
a
dynamic
interplay
between
immune
signaling
cellular
metabolism
that
is
referred
to
as
immunometabolism.
This
review
explores
crosstalk
metabolic
pathways
including
glycolysis,
oxidative
phosphorylation,
fatty
acid
metabolism,
processes
govern
cardiac
aging.
With
rapidly
population
coincides
with
increased
cardiovascular
risk
cancer
incidence
rates,
understanding
immunometabolic
underpinnings
of
provides
foundation
for
identifying
therapeutic
targets
mitigate
dysfunction.
Aging
alters
environment
concomitantly
driving
cell
mitochondrial
dysfunction,
redox
signaling.
Shifts
these
exacerbate
inflammation
impair
tissue
repair,
creating
vicious
cycle
accelerates
functional
decline.
Treatment
therapy
further
complicates
this
landscape,
aging-associated
disruptions
augment
susceptibility
cardiotoxicity.
The
current
highlights
strategies
target
axis
alleviate
pathologies.
Interventions
include
modulating
intermediates,
improving
function,
leveraging
restore
health.
Advances
immunometabolism
thus
hold
significant
potential
translating
preclinical
findings
into
therapies
improve
quality
life
underscore
need
approaches
address
mechanisms
aging,
providing
framework
future
research.
Язык: Английский