Pyrroloquinoline Quinone Alleviates Mitochondria Damage in Radiation-Induced Lung Injury in a MOTS-c-Dependent Manner
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
Radiation-induced
lung
injury
(RILI)
is
a
prevalent
complication
of
thoracic
tumor
radiotherapy
and
accidental
radiation
exposure.
Pyrroloquinoline
quinone
(PQQ),
novel
vitamin
B,
plays
crucial
role
in
delaying
aging,
antioxidation,
anti-inflammation,
antiapoptosis.
This
study
aims
to
investigate
the
protective
effect
mechanisms
PQQ
against
RILI.
C57BL/6
mice
were
exposed
20
Gy
dose
X-ray
on
entire
thorax
with
or
without
daily
oral
administration
for
2
weeks.
effectively
mitigated
radiation-induced
tissue
damage,
inflammation,
oxidative
stress,
epithelial
cell
apoptosis.
Additionally,
significantly
inhibited
stress
mitochondrial
damage
MLE-12
cells.
Mechanistically,
upregulated
mRNA
protein
levels
MOTS-c
irradiated
Knockdown
by
siRNA
substantially
attenuated
effects
In
conclusion,
alleviates
RILI
preserving
function
through
MOTS-c-dependent
mechanism,
suggesting
that
may
serve
as
promising
nutraceutical
intervention
Язык: Английский
The role of NRF2 function and regulation in atherosclerosis: an update
Molecular and Cellular Biochemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
SIRT6 mitigates doxorubicin-induced cardiomyopathy via amelioration of mitochondrial dysfunction: A mechanistic study implicating the activation of the Nrf-2/FUNDC1 signaling axis
International Journal of Medical Sciences,
Год журнала:
2025,
Номер
22(7), С. 1640 - 1657
Опубликована: Фев. 28, 2025
Doxorubicin-induced
myocardial
injury,
characterized
by
hypertrophy
and
heart
failure
(HF),
represents
a
primary
contributor
to
end-stage
cardiovascular
mortality
associated
with
anthracycline
drugs.
Prior
research
has
elucidated
that
SIRT6-mediated
oxidative
processes
mitochondrial
metabolic
reprogramming
are
pivotal
in
sustaining
energy
metabolism
during
damage
cardiomyocytes.
In
the
aftermath
of
doxorubicin-induced
fibrosis
exacerbate
impairment
cardiac
ejection
function,
resulting
elevated
oxygen
consumption.
This
condition
is
accompanied
disrupted
ATP
production,
diminished
biogenesis,
inadequate
synthesis
new
DNA,
collectively
triggering
necroptosis
apoptosis
pathways.
Our
preliminary
experimental
results
have
confirmed
SIRT6,
traditional
medicine,
exerts
cardioprotective
effects.
Nevertheless,
interaction
between
SIRT6
Nrf-2-mediated
biogenesis
context
HF
remains
inadequately
understood.
The
generation
mitochondria
key
mechanism
involved
DNA
repair
cell
cycle
management.
Язык: Английский
MicroRNAs as Regulators of Radiation-Induced Oxidative Stress
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(7), С. 7097 - 7113
Опубликована: Июль 6, 2024
microRNAs
(miRNAs)
represent
small
RNA
molecules
involved
in
the
regulation
of
gene
expression.
They
are
implicated
diverse
cellular
processes
ranging
from
homeostasis
to
stress
responses.
Unintended
irradiation
cells
and
tissues,
e.g.,
during
medical
uses,
induces
various
pathological
conditions,
including
oxidative
stress.
miRNAs
may
regulate
expression
transcription
factors
(e.g.,
nuclear
factor
erythroid
2
related
(Nrf2),
kappa
B
(NF-κB),
tumor
suppressor
protein
p53)
other
redox-sensitive
genes
mitogen-activated
kinase
(MAPKs),
sirtuins
(SIRTs)),
which
trigger
modulate
redox
signaling.
During
irradiation,
mainly
act
with
reactive
oxygen
species
(ROS)
cell
fate.
Depending
on
pathway
extent
stress,
this
lead
survival
or
death.
In
context
radiation-induced
miRNA-21
miRNA-34a
among
best-studied
miRNAs.
has
been
shown
directly
target
superoxide
dismutase
(SOD),
NF-κB,
whereas
is
a
direct
regulator
NADPH
oxidase
(NOX),
SIRT1,
p53.
Understanding
mechanisms
underlying
injury
involvement
redox-responsive
help
develop
novel
approaches
for
modulating
response
radiation
exposure.
Язык: Английский