Diagnostics,
Год журнала:
2024,
Номер
14(24), С. 2880 - 2880
Опубликована: Дек. 21, 2024
Background:
The
prognostic
value
of
the
neutrophil–lymphocyte
ratio
(NLR)
in
ischemic
stroke
remains
debated
due
to
cohort
variability
and
treatment
heterogeneity
across
studies.
This
study
evaluates
relationship
between
admission
NLR,
severity
90-day
outcomes
patients
with
anterior
circulation
large
vessel
occlusion
(LVO)
undergoing
early,
successful
revascularization.
Methods:
A
retrospective
multicenter
was
conducted
1082
treated
mechanical
thrombectomy
for
acute
stroke.
baseline
National
Institutes
Health
Stroke
Scale
(NIHSS),
24
h
NIHSS
modified
Rankin
(mRS)
analyzed
using
logistic
regression.
Results:
Admission
NLR
correlated
weakly
but
significantly
both
(p
=
0.018)
0.005)
scores,
reflecting
severity.
However,
multivariate
analysis
showed
that
higher
scores
(OR
0.831,
p
0.000)
prolonged
puncture-to-recanalization
times
0.981,
were
independent
predictors
poor
outcomes,
whereas
not
0.557).
Conclusions:
is
associated
does
independently
predict
clinical
at
90
days
achieving
early
These
findings
underscore
critical
role
inflammation
phase
suggest
its
long-term
limited
this
context.
Journal of Cerebral Blood Flow & Metabolism,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
The
results
of
a
Phase
1
trial
autologous
mitochondrial
transplantation
for
the
treatment
acute
ischemic
stroke
during
mechanical
thrombectomy
are
presented.
Standardized
methods
were
used
to
isolate
viable
mitochondria
in
clinical
setting,
allowing
timely
within
window.
No
significant
adverse
events
observed
with
endovascular
approach
reperfusion
therapy.
Safety
outcomes
study
participants
comparable
those
matched
controls
who
did
not
undergo
transplantation.
This
represents
first
use
human
brain,
highlighting
specific
logistical
challenges
related
such
as
limited
tissue
samples
and
constrained
time
isolation
We
also
review
opportunities
associated
further
translation
context
cerebral
ischemia
beyond.
Frontiers in Neurology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 29, 2025
Background
The
systemic
immune–inflammation
index
(SII)
is
a
composite
and
easily
available
inflammation
index,
which
can
quantitatively
reflect
the
degree
of
inflammation.
This
study
aims
to
investigate
predictive
value
admission
SII
for
outcomes
large
artery
occlusion
treated
with
mechanical
thrombectomy
(MT).
Methods
retrospective
was
conducted
at
Suining
Central
Hospital,
Sichuan,
China.
Patients
were
stratified
into
quartiles
based
on
their
SII.
investigating
included
hemorrhagic
transformation
(HT),
malignant
brain
edema
(MBE),
90-day
functional
outcome,
mortality.
adverse
function
defined
as
modified
Rankin
Scale
(mRS)
score
>
2
follow-up.
Multivariate
analysis
performed
explore
relationships
between
outcomes.
In
addition,
cases
(distinguished
from
aforementioned
patients)
MT
+
mild
hypothermia
(MH)
also
elucidate
SII/MH
in
new
cohort.
Results
A
total
323
patients
included.
observed
HT,
MBE,
function,
mortality
rates
31.9,
25.7,
59.4,
27.9%,
respectively.
demonstrated
that
heightened
significantly
related
HT
(odds
ratio
[OR]:
1.061,
95%
confidence
interval
[CI]:
1.035–1.086,
p
<
0.001),
MBE
(OR:
1.074,
CI:
1.045–1.103,
1.031–1.092,
1.044,
1.018–1.070,
=
after
adjusting
sex,
age,
Glasgow
Coma
(GCS)
admission,
initial
National
Institutes
Health
Stroke
(NIHSS)
score,
baseline
Alberta
Program
Early
Computed
Tomography
Score
(ASPECTS),
present
HMCAS,
occluded
vessel
region,
collateral
successful
revascularization.
may
partially
account
elevated
SII’s
criterion
ASPECTS
≤
7,
42
MH
enrolled
build
up
cohort
combined
72
mere
MT.
risk
role
protect
effect
identified
(SII—OR:
1.037,
1.001–1.074;
MH—OR:
0.361,
0.136–0.957),
1.063,
1.019–1.109;
0.231,
0.081–0.653),
1.048,
1.011–1.087;
0.343,
0.118–0.994).
Conclusion
Elevated
improve
prognosis
under
high
status.
This
study
aims
to
evaluate
the
clinical
and
imaging
risk
factors
for
early
neurological
deterioration
(END)
long-term
disability
in
patients
with
Single
subcortical
small
infarction
(SSSI).
We
retrospectively
included
SSSI
hospitalized.
Outcomes
were
defined
as
modified
Rankin
Scale
(mRS)
score
>
2
at
follow-up
occurrence
of
END
during
hospitalization.
Multivariate
logistic
regression
identified
independent
predictors
outcomes.
Stepwise
analysis
was
used
develop
a
predictive
model
poor
The
performance
assessed
using
receiver
operating
characteristic
(ROC)
curves.
A
total
289
included.
During
hospitalization,
18
(6.2%)
experienced
END,
29
(10%)
had
median
21.4
(16.7-25.2)
months.
showed
National
Institutes
Health
Stroke
(NIHSS)
score(OR
1.43,
95%
CI
1.19-1.73,
P
<
0.001),
neutrophil
high-density
lipoprotein
cholesterol
ratio
(NHR)
(OR
1.28,
1.02-1.60,
=
0.034)
independently
associated
END.
Age
1.08,
1.01-1.15,
0.028),
NIHSS
1.60,
1.29-1.98,
symptomatic
intracranial
artery
stenosis
5.26,
1.56-17.71,
0.007),
lacune
number
1.51,
1.13-2.04,
0.006),
degree
brain
atrophy
2.03,
1.19-3.46,
0.01),
mean
hemoglobin
concentration
(MCHC)
0.96,
0.92-0.99,
0.04)
disability.
(included
NHR
level)
age,
score,
stenosis,
lacunes,
atrophy)
areas
under
ROC
curve
0.836
0.926,
respectively.
High
are
Age,
NIHSS,
patients.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Abstract
The
full
text
of
this
preprint
has
been
withdrawn
by
the
authors
while
they
make
corrections
to
work.
Therefore,
do
not
wish
work
be
cited
as
a
reference.
Questions
should
directed
corresponding
author.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(11), С. 3808 - 3808
Опубликована: Май 29, 2025
Background/Objectives:
Patients
with
aneurysmal
subarachnoid
hemorrhage
(SAH)
experience
functional
impairment
due
to
early
brain
injury
and
delayed
complications.
We
aimed
clarify
the
association
between
cerebral
edema
post-SAH
infection.
investigated
whether
this
leads
ischemia
(DCI)
poor
clinical
outcomes.
Methods:
included
189
patients
diagnosed
SAH
at
our
institution.
Demographic
data
on
World
Federation
of
Neurological
Surgeons
(WFNS)
grade,
modified
Fisher
aneurysm
location,
treatment
methods,
global
(GCE)
assessed
according
Subarachnoid
Hemorrhage
Early
Brain
Edema
Score
(SEBES),
DCI,
infection,
duration
hospital
stay,
Rankin
Scale
3
months
were
collected.
Results:
Overall,
88
(46.6%)
developed
GCE
([SEBES]
or
4),
while
101
(53.4%)
did
not.
DCI
was
observed
in
58
(30.7%)
patients.
Infectious
complications
occurred
80
(42.3%)
Kaplan–Meier
analysis
results
suggested
a
higher
frequency
among
infection
than
those
without
(p
<
0.01).
Logistic
regression
identified
0.001,
odds
ratio
[OR]
3.3,
95%
confidence
interval
[CI]
[1.3–8.6]),
older
age
=
0.02,
OR
2.5,
95%CI
[1.2–4.9]),
WFNS
grade
0.01,
3.9,
[1.5–9.5]),
mechanical
ventilation
use
0.04,
1.4,
[1.1–3.9])
as
risk
factors
for
0.03,
2.3,
[1.1–4.6]),
4.5,
[1.5–9.2]),
+
4.1,
[1.3–8.9])
independent
DCI.
Conclusions:
GCE–infection
linkage
is
associated
outcomes,
longer
stays
SAH.
Therefore,
EBI-DCI
chain
plays
an
important
role
postsurgical
management
these
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 28, 2024
AbstractIntroduction:
This
study
aims
to
evaluate
the
clinical
and
imaging
risk
factors
for
early
neurological
deterioration
(END)
long-term
disability
in
patients
with
Single
subcortical
small
infarction
(SSSI).
Methods:
We
retrospectively
included
SSSI
hospitalized.
Outcomes
were
defined
as
modified
Rankin
Scale
(mRS)
score
>2
at
follow-up
occurrence
of
END
during
hospitalization.
Multivariate
logistic
regression
identified
independent
predictors
outcomes.
Stepwise
analysis
was
used
develop
a
predictive
model
poor
The
performance
assessed
using
receiver
operating
characteristic
(ROC)
curves.
Results:
A
total
289
included.
During
hospitalization,
18
(6.2%)
experienced
END,
29
(10%)
had
median
21.4
(16.7–25.2)
months.
showed
National
Institutes
Health
Stroke
(NIHSS)
(OR
1.438,
95%
CI
1.182–1.749,
P
<
0.001),
Total
cholesterol
(TC)
1.545,
1.014–2.355,
=
0.043),
neutrophil
High
density
lipoprotein
ratio
(NHR)
1.371,
1.074–1.75,
0.011),
count
1.333,
1.025–1.733,
0.032)
independently
associated
END.
Age
1.083,
1.008–1.163,
0.029),
lesion
diameter
1.121,
1.001–1.255,
0.048),
NIHSS
1.685,
1.33–2.134,
symptomatic
intracranial
artery
stenosis
6.655,
1.618–27.38,
0.009),
lacune
grading
3.644,
1.468–9.048,
0.005),
degree
brain
atrophy
2.232,
1.199–4.154,
0.011)
disability.
(included
NHR
level)
age,
score,
stenosis,
number
lacunes,
atrophy)
areas
under
ROC
curve
0.836
0.926,
respectively.
Conclusion:
High
NIHSS,
TC,
NHR,
are
Age,
size,
lacunes
patients.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Abstract
This
study
examines
the
associations
between
neutrophil-to-lymphocyte
ratio
(NLR),
systemic
inflammation
response
index
(SIRI)
and
clinical
outcomes
of
intracerebral
hemorrhagic
(ICH)
stroke
patients.
We
recruited
investigated
longitudinally
294
ICH
patients
in
a
general
tertiary
hospital
Sichuan
Province,
China
at
baseline
(admission),
1-month
post-discharge,
3-month
post-discharge
6-month
from
January
2020
to
2022.
calculated
NLR
SIRI
blood
samples
collected
baseline.
The
Mann-Whitney
test,
logistic
regression
analysis
receiver
operating
characteristic
(ROC)
were
performed
evaluate
differences
three
follow-up
time
points.
interaction
these
variables
was
evaluated
via
multiplicative
additive
models.
Our
revealed
that
cut-off
values
predict
determined
be
6
4,
respectively.
>
(OR
2.202,
95%
CI:
1.094–4.430)
4
2.056,
1.065–3.968)
associated
with
increased
risks
for
poor
post-discharge.
2.428,
1.389–4.243)
1.978,
1.093–3.580)
did
not
have
an
effect
on
outcome
findings
indicate
high
NLRs
SIRIs,
particularly
are
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 11057 - 11072
Опубликована: Дек. 1, 2024
The
systemic
inflammation
response
index
(SIRI)
has
recently
emerged
as
a
novel
inflammatory
and
prognostic
marker
across
various
diseases.
However,
there
is
limited
research
examining
the
relationship
between
SIRI
90-day
functional
outcome
in
patients
with
acute
large
vessel
occlusion
stroke
(ALVOS)
undergoing
mechanical
thrombectomy
(MT).
This
study
aimed
to
investigate
potential
of
an
innovative,
inflammation-based
predictor
outcome.