Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review

Journal of Cerebral Blood Flow & Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

The results of a Phase 1 trial autologous mitochondrial transplantation for the treatment acute ischemic stroke during mechanical thrombectomy are presented. Standardized methods were used to isolate viable mitochondria in clinical setting, allowing timely within window. No significant adverse events observed with endovascular approach reperfusion therapy. Safety outcomes study participants comparable those matched controls who did not undergo transplantation. This represents first use human brain, highlighting specific logistical challenges related such as limited tissue samples and constrained time isolation We also review opportunities associated further translation context cerebral ischemia beyond.

Язык: Английский

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Hyponatremia is associated with malignant brain edema after mechanical thrombectomy in acute ischemic stroke

BMC Neurology, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 28, 2025

Язык: Английский

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Predictive value of the systemic immune–inflammation index for outcomes in large artery occlusion treated with mechanical thrombectomy—a single-center study

Frontiers in Neurology, Год журнала: 2025, Номер 15

Опубликована: Янв. 29, 2025

Background The systemic immune–inflammation index (SII) is a composite and easily available inflammation index, which can quantitatively reflect the degree of inflammation. This study aims to investigate predictive value admission SII for outcomes large artery occlusion treated with mechanical thrombectomy (MT). Methods retrospective was conducted at Suining Central Hospital, Sichuan, China. Patients were stratified into quartiles based on their SII. investigating included hemorrhagic transformation (HT), malignant brain edema (MBE), 90-day functional outcome, mortality. adverse function defined as modified Rankin Scale (mRS) score > 2 follow-up. Multivariate analysis performed explore relationships between outcomes. In addition, cases (distinguished from aforementioned patients) MT + mild hypothermia (MH) also elucidate SII/MH in new cohort. Results A total 323 patients included. observed HT, MBE, function, mortality rates 31.9, 25.7, 59.4, 27.9%, respectively. demonstrated that heightened significantly related HT (odds ratio [OR]: 1.061, 95% confidence interval [CI]: 1.035–1.086, p < 0.001), MBE (OR: 1.074, CI: 1.045–1.103, 1.031–1.092, 1.044, 1.018–1.070, = after adjusting sex, age, Glasgow Coma (GCS) admission, initial National Institutes Health Stroke (NIHSS) score, baseline Alberta Program Early Computed Tomography Score (ASPECTS), present HMCAS, occluded vessel region, collateral successful revascularization. may partially account elevated SII’s criterion ASPECTS ≤ 7, 42 MH enrolled build up cohort combined 72 mere MT. risk role protect effect identified (SII—OR: 1.037, 1.001–1.074; MH—OR: 0.361, 0.136–0.957), 1.063, 1.019–1.109; 0.231, 0.081–0.653), 1.048, 1.011–1.087; 0.343, 0.118–0.994). Conclusion Elevated improve prognosis under high status.

Язык: Английский

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Clinical and imaging risk factors for early neurological deterioration and long-term neurological disability in patients with single subcortical small infarction

BMC Neurology, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 15, 2025

This study aims to evaluate the clinical and imaging risk factors for early neurological deterioration (END) long-term disability in patients with Single subcortical small infarction (SSSI). We retrospectively included SSSI hospitalized. Outcomes were defined as modified Rankin Scale (mRS) score > 2 at follow-up occurrence of END during hospitalization. Multivariate logistic regression identified independent predictors outcomes. Stepwise analysis was used develop a predictive model poor The performance assessed using receiver operating characteristic (ROC) curves. A total 289 included. During hospitalization, 18 (6.2%) experienced END, 29 (10%) had median 21.4 (16.7-25.2) months. showed National Institutes Health Stroke (NIHSS) score(OR 1.43, 95% CI 1.19-1.73, P < 0.001), neutrophil high-density lipoprotein cholesterol ratio (NHR) (OR 1.28, 1.02-1.60, = 0.034) independently associated END. Age 1.08, 1.01-1.15, 0.028), NIHSS 1.60, 1.29-1.98, symptomatic intracranial artery stenosis 5.26, 1.56-17.71, 0.007), lacune number 1.51, 1.13-2.04, 0.006), degree brain atrophy 2.03, 1.19-3.46, 0.01), mean hemoglobin concentration (MCHC) 0.96, 0.92-0.99, 0.04) disability. (included NHR level) age, score, stenosis, lacunes, atrophy) areas under ROC curve 0.836 0.926, respectively. High are Age, NIHSS, patients.

Язык: Английский

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WITHDRAWN: Neutrophil-to-Lymphocyte Ratio and Systemic Inflammation Response Index as Biomarkers for the Clinical Outcomes of Intracerebral Hemorrhagic Stroke Patients: A Longitudinal Design Study

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

The full text of this preprint has been withdrawn by the authors while they make corrections to work. Therefore, do not wish work be cited as a reference. Questions should directed corresponding author.

Язык: Английский

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Association Between Red Cell Distribution Width and Erectile Dysfunction: A Cross-Sectional Study Using NHANES 2001–2004 Data

Journal of Reproductive Immunology, Год журнала: 2025, Номер unknown, С. 104536 - 104536

Опубликована: Май 1, 2025

Язык: Английский

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Infection Associated with Global Cerebral Edema and Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(11), С. 3808 - 3808

Опубликована: Май 29, 2025

Background/Objectives: Patients with aneurysmal subarachnoid hemorrhage (SAH) experience functional impairment due to early brain injury and delayed complications. We aimed clarify the association between cerebral edema post-SAH infection. investigated whether this leads ischemia (DCI) poor clinical outcomes. Methods: included 189 patients diagnosed SAH at our institution. Demographic data on World Federation of Neurological Surgeons (WFNS) grade, modified Fisher aneurysm location, treatment methods, global (GCE) assessed according Subarachnoid Hemorrhage Early Brain Edema Score (SEBES), DCI, infection, duration hospital stay, Rankin Scale 3 months were collected. Results: Overall, 88 (46.6%) developed GCE ([SEBES] or 4), while 101 (53.4%) did not. DCI was observed in 58 (30.7%) patients. Infectious complications occurred 80 (42.3%) Kaplan–Meier analysis results suggested a higher frequency among infection than those without (p < 0.01). Logistic regression identified 0.001, odds ratio [OR] 3.3, 95% confidence interval [CI] [1.3–8.6]), older age = 0.02, OR 2.5, 95%CI [1.2–4.9]), WFNS grade 0.01, 3.9, [1.5–9.5]), mechanical ventilation use 0.04, 1.4, [1.1–3.9]) as risk factors for 0.03, 2.3, [1.1–4.6]), 4.5, [1.5–9.2]), + 4.1, [1.3–8.9]) independent DCI. Conclusions: GCE–infection linkage is associated outcomes, longer stays SAH. Therefore, EBI-DCI chain plays an important role postsurgical management these

Язык: Английский

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Clinical and Imaging Risk Factors for Early Neurological Deterioration and Long-Term Neurological Disability in Patients with Single Subcortical Small Infarction

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 28, 2024

Introduction: This study aims to evaluate the clinical and imaging risk factors for early neurological deterioration (END) long-term disability in patients with Single subcortical small infarction (SSSI). Methods: We retrospectively included SSSI hospitalized. Outcomes were defined as modified Rankin Scale (mRS) score >2 at follow-up occurrence of END during hospitalization. Multivariate logistic regression identified independent predictors outcomes. Stepwise analysis was used develop a predictive model poor The performance assessed using receiver operating characteristic (ROC) curves. Results: A total 289 included. During hospitalization, 18 (6.2%) experienced END, 29 (10%) had median 21.4 (16.7–25.2) months. showed National Institutes Health Stroke (NIHSS) (OR 1.438, 95% CI 1.182–1.749, P < 0.001), Total cholesterol (TC) 1.545, 1.014–2.355, = 0.043), neutrophil High density lipoprotein ratio (NHR) 1.371, 1.074–1.75, 0.011), count 1.333, 1.025–1.733, 0.032) independently associated END. Age 1.083, 1.008–1.163, 0.029), lesion diameter 1.121, 1.001–1.255, 0.048), NIHSS 1.685, 1.33–2.134, symptomatic intracranial artery stenosis 6.655, 1.618–27.38, 0.009), lacune grading 3.644, 1.468–9.048, 0.005), degree brain atrophy 2.232, 1.199–4.154, 0.011) disability. (included NHR level) age, score, stenosis, number lacunes, atrophy) areas under ROC curve 0.836 0.926, respectively. Conclusion: High NIHSS, TC, NHR, are Age, size, lacunes patients.

Язык: Английский

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Neutrophil-to-Lymphocyte Ratio and Systemic Inflammation Response Index as Biomarkers for the Clinical Outcomes of Intracerebral Hemorrhagic Stroke Patients: A Longitudinal Design Study

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

This study examines the associations between neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI) and clinical outcomes of intracerebral hemorrhagic (ICH) stroke patients. We recruited investigated longitudinally 294 ICH patients in a general tertiary hospital Sichuan Province, China at baseline (admission), 1-month post-discharge, 3-month post-discharge 6-month from January 2020 to 2022. calculated NLR SIRI blood samples collected baseline. The Mann-Whitney test, logistic regression analysis receiver operating characteristic (ROC) were performed evaluate differences three follow-up time points. interaction these variables was evaluated via multiplicative additive models. Our revealed that cut-off values predict determined be 6 4, respectively. > (OR 2.202, 95% CI: 1.094–4.430) 4 2.056, 1.065–3.968) associated with increased risks for poor post-discharge. 2.428, 1.389–4.243) 1.978, 1.093–3.580) did not have an effect on outcome findings indicate high NLRs SIRIs, particularly are

Язык: Английский

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Association of the Systemic Inflammation Response Index with Functional Outcome in Acute Large Vessel Occlusion Stroke Patients Receiving Mechanical Thrombectomy

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 11057 - 11072

Опубликована: Дек. 1, 2024

The systemic inflammation response index (SIRI) has recently emerged as a novel inflammatory and prognostic marker across various diseases. However, there is limited research examining the relationship between SIRI 90-day functional outcome in patients with acute large vessel occlusion stroke (ALVOS) undergoing mechanical thrombectomy (MT). This study aimed to investigate potential of an innovative, inflammation-based predictor outcome.

Язык: Английский

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