Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Stroke DOI Creative Commons
Zülfikar Memiş, Erdem Gürkaş, Atilla Özcan Özdemir

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2880 - 2880

Published: Dec. 21, 2024

Background: The prognostic value of the neutrophil–lymphocyte ratio (NLR) in ischemic stroke remains debated due to cohort variability and treatment heterogeneity across studies. This study evaluates relationship between admission NLR, severity 90-day outcomes patients with anterior circulation large vessel occlusion (LVO) undergoing early, successful revascularization. Methods: A retrospective multicenter was conducted 1082 treated mechanical thrombectomy for acute stroke. baseline National Institutes Health Stroke Scale (NIHSS), 24 h NIHSS modified Rankin (mRS) analyzed using logistic regression. Results: Admission NLR correlated weakly but significantly both (p = 0.018) 0.005) scores, reflecting severity. However, multivariate analysis showed that higher scores (OR 0.831, p 0.000) prolonged puncture-to-recanalization times 0.981, were independent predictors poor outcomes, whereas not 0.557). Conclusions: is associated does independently predict clinical at 90 days achieving early These findings underscore critical role inflammation phase suggest its long-term limited this context.

Language: Английский

Hyponatremia is associated with malignant brain edema after mechanical thrombectomy in acute ischemic stroke DOI Creative Commons
Ao Qian,

Longyi Zheng,

Jia Duan

et al.

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 28, 2025

Language: Английский

Citations

0
Predictive value of the systemic immune–inflammation index for outcomes in large artery occlusion treated with mechanical thrombectomy—a single-center study DOI Creative Commons
Ao Qian,

Longyi Zheng,

Hui He

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 29, 2025

Background The systemic immune–inflammation index (SII) is a composite and easily available inflammation index, which can quantitatively reflect the degree of inflammation. This study aims to investigate predictive value admission SII for outcomes large artery occlusion treated with mechanical thrombectomy (MT). Methods retrospective was conducted at Suining Central Hospital, Sichuan, China. Patients were stratified into quartiles based on their SII. investigating included hemorrhagic transformation (HT), malignant brain edema (MBE), 90-day functional outcome, mortality. adverse function defined as modified Rankin Scale (mRS) score > 2 follow-up. Multivariate analysis performed explore relationships between outcomes. In addition, cases (distinguished from aforementioned patients) MT + mild hypothermia (MH) also elucidate SII/MH in new cohort. Results A total 323 patients included. observed HT, MBE, function, mortality rates 31.9, 25.7, 59.4, 27.9%, respectively. demonstrated that heightened significantly related HT (odds ratio [OR]: 1.061, 95% confidence interval [CI]: 1.035–1.086, p < 0.001), MBE (OR: 1.074, CI: 1.045–1.103, 1.031–1.092, 1.044, 1.018–1.070, = after adjusting sex, age, Glasgow Coma (GCS) admission, initial National Institutes Health Stroke (NIHSS) score, baseline Alberta Program Early Computed Tomography Score (ASPECTS), present HMCAS, occluded vessel region, collateral successful revascularization. may partially account elevated SII’s criterion ASPECTS ≤ 7, 42 MH enrolled build up cohort combined 72 mere MT. risk role protect effect identified (SII—OR: 1.037, 1.001–1.074; MH—OR: 0.361, 0.136–0.957), 1.063, 1.019–1.109; 0.231, 0.081–0.653), 1.048, 1.011–1.087; 0.343, 0.118–0.994). Conclusion Elevated improve prognosis under high status.

Language: Английский

Citations

0
Clinical and imaging risk factors for early neurological deterioration and long-term neurological disability in patients with single subcortical small infarction DOI Creative Commons
Feng Xiao,

Meiherinisa Taiwakuli,

Junyong Du

et al.

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 15, 2025

This study aims to evaluate the clinical and imaging risk factors for early neurological deterioration (END) long-term disability in patients with Single subcortical small infarction (SSSI). We retrospectively included SSSI hospitalized. Outcomes were defined as modified Rankin Scale (mRS) score > 2 at follow-up occurrence of END during hospitalization. Multivariate logistic regression identified independent predictors outcomes. Stepwise analysis was used develop a predictive model poor The performance assessed using receiver operating characteristic (ROC) curves. A total 289 included. During hospitalization, 18 (6.2%) experienced END, 29 (10%) had median 21.4 (16.7-25.2) months. showed National Institutes Health Stroke (NIHSS) score(OR 1.43, 95% CI 1.19-1.73, P < 0.001), neutrophil high-density lipoprotein cholesterol ratio (NHR) (OR 1.28, 1.02-1.60, = 0.034) independently associated END. Age 1.08, 1.01-1.15, 0.028), NIHSS 1.60, 1.29-1.98, symptomatic intracranial artery stenosis 5.26, 1.56-17.71, 0.007), lacune number 1.51, 1.13-2.04, 0.006), degree brain atrophy 2.03, 1.19-3.46, 0.01), mean hemoglobin concentration (MCHC) 0.96, 0.92-0.99, 0.04) disability. (included NHR level) age, score, stenosis, lacunes, atrophy) areas under ROC curve 0.836 0.926, respectively. High are Age, NIHSS, patients.

Language: Английский

Citations

0
WITHDRAWN: Neutrophil-to-Lymphocyte Ratio and Systemic Inflammation Response Index as Biomarkers for the Clinical Outcomes of Intracerebral Hemorrhagic Stroke Patients: A Longitudinal Design Study DOI

Ziyi HU,

Wei Zhu,

L. Wang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Abstract The full text of this preprint has been withdrawn by the authors while they make corrections to work. Therefore, do not wish work be cited as a reference. Questions should directed corresponding author.

Language: Английский

Citations

0
Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review DOI
Melanie Walker, Michael R. Levitt, Emma Federico

et al.

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

The results of a Phase 1 trial autologous mitochondrial transplantation for the treatment acute ischemic stroke during mechanical thrombectomy are presented. Standardized methods were used to isolate viable mitochondria in clinical setting, allowing timely within window. No significant adverse events observed with endovascular approach reperfusion therapy. Safety outcomes study participants comparable those matched controls who did not undergo transplantation. This represents first use human brain, highlighting specific logistical challenges related such as limited tissue samples and constrained time isolation We also review opportunities associated further translation context cerebral ischemia beyond.

Language: Английский

Citations

3
Clinical and Imaging Risk Factors for Early Neurological Deterioration and Long-Term Neurological Disability in Patients with Single Subcortical Small Infarction DOI Creative Commons

Xiao feng,

Meiherinisa Taiwakuli,

junyong Du

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Abstract Introduction: This study aims to evaluate the clinical and imaging risk factors for early neurological deterioration (END) long-term disability in patients with Single subcortical small infarction (SSSI). Methods: We retrospectively included SSSI hospitalized. Outcomes were defined as modified Rankin Scale (mRS) score >2 at follow-up occurrence of END during hospitalization. Multivariate logistic regression identified independent predictors outcomes. Stepwise analysis was used develop a predictive model poor The performance assessed using receiver operating characteristic (ROC) curves. Results: A total 289 included. During hospitalization, 18 (6.2%) experienced END, 29 (10%) had median 21.4 (16.7–25.2) months. showed National Institutes Health Stroke (NIHSS) (OR 1.438, 95% CI 1.182–1.749, P < 0.001), Total cholesterol (TC) 1.545, 1.014–2.355, = 0.043), neutrophil High density lipoprotein ratio (NHR) 1.371, 1.074–1.75, 0.011), count 1.333, 1.025–1.733, 0.032) independently associated END. Age 1.083, 1.008–1.163, 0.029), lesion diameter 1.121, 1.001–1.255, 0.048), NIHSS 1.685, 1.33–2.134, symptomatic intracranial artery stenosis 6.655, 1.618–27.38, 0.009), lacune grading 3.644, 1.468–9.048, 0.005), degree brain atrophy 2.232, 1.199–4.154, 0.011) disability. (included NHR level) age, score, stenosis, number lacunes, atrophy) areas under ROC curve 0.836 0.926, respectively. Conclusion: High NIHSS, TC, NHR, are Age, size, lacunes patients.

Language: Английский

Citations

0
Neutrophil-to-Lymphocyte Ratio and Systemic Inflammation Response Index as Biomarkers for the Clinical Outcomes of Intracerebral Hemorrhagic Stroke Patients: A Longitudinal Design Study DOI Creative Commons

Ziyi HU,

Wei Zhu,

L. Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Abstract This study examines the associations between neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI) and clinical outcomes of intracerebral hemorrhagic (ICH) stroke patients. We recruited investigated longitudinally 294 ICH patients in a general tertiary hospital Sichuan Province, China at baseline (admission), 1-month post-discharge, 3-month post-discharge 6-month from January 2020 to 2022. calculated NLR SIRI blood samples collected baseline. The Mann-Whitney test, logistic regression analysis receiver operating characteristic (ROC) were performed evaluate differences three follow-up time points. interaction these variables was evaluated via multiplicative additive models. Our revealed that cut-off values predict determined be 6 4, respectively. > (OR 2.202, 95% CI: 1.094–4.430) 4 2.056, 1.065–3.968) associated with increased risks for poor post-discharge. 2.428, 1.389–4.243) 1.978, 1.093–3.580) did not have an effect on outcome findings indicate high NLRs SIRIs, particularly are

Language: Английский

Citations

0
Association of the Systemic Inflammation Response Index with Functional Outcome in Acute Large Vessel Occlusion Stroke Patients Receiving Mechanical Thrombectomy DOI Creative Commons
Wen Wu, Yupei Zhang,

Xingguang Qu

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 11057 - 11072

Published: Dec. 1, 2024

The systemic inflammation response index (SIRI) has recently emerged as a novel inflammatory and prognostic marker across various diseases. However, there is limited research examining the relationship between SIRI 90-day functional outcome in patients with acute large vessel occlusion stroke (ALVOS) undergoing mechanical thrombectomy (MT). This study aimed to investigate potential of an innovative, inflammation-based predictor outcome.

Language: Английский

Citations

0
Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Stroke DOI Creative Commons
Zülfikar Memiş, Erdem Gürkaş, Atilla Özcan Özdemir

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2880 - 2880

Published: Dec. 21, 2024

Background: The prognostic value of the neutrophil–lymphocyte ratio (NLR) in ischemic stroke remains debated due to cohort variability and treatment heterogeneity across studies. This study evaluates relationship between admission NLR, severity 90-day outcomes patients with anterior circulation large vessel occlusion (LVO) undergoing early, successful revascularization. Methods: A retrospective multicenter was conducted 1082 treated mechanical thrombectomy for acute stroke. baseline National Institutes Health Stroke Scale (NIHSS), 24 h NIHSS modified Rankin (mRS) analyzed using logistic regression. Results: Admission NLR correlated weakly but significantly both (p = 0.018) 0.005) scores, reflecting severity. However, multivariate analysis showed that higher scores (OR 0.831, p 0.000) prolonged puncture-to-recanalization times 0.981, were independent predictors poor outcomes, whereas not 0.557). Conclusions: is associated does independently predict clinical at 90 days achieving early These findings underscore critical role inflammation phase suggest its long-term limited this context.

Language: Английский

Citations

0