Mechanisms of Aortic Dissection: From Pathological Changes to Experimental and In Silico Models

Progress in Materials Science, Год журнала: 2024, Номер 150, С. 101363 - 101363

Опубликована: Сен. 12, 2024

Aortic dissection continues to be responsible for significant morbidity and mortality, although recent advances in medical data assimilation experimental silico models have improved our understanding of the initiation progression accumulation blood within aortic wall. Hence, there remains a pressing necessity innovative enhanced more accurately characterize associated pathological changes. Early on, were employed uncover mechanisms dissection, such as hemodynamic changes alterations wall microstructure, assess efficacy implants. While once only option available, recently they are also being used validate models. Based on an deteriorated microstructure wall, numerous multiscale material been proposed decades study state stress dissected aortas, including with damage failure. Furthermore, when integrated accessible patient-derived data, prove invaluable tool identifying correlations between hemodynamics, stresses, or thrombus formation They advantageous model-guided design implants aim evaluating deployment migration patients. Nonetheless, utility depends largely chosen boundary conditions tissue properties. In this review article, objective is provide thorough summary elucidating disease. Concurrently, we models, well patient data-informed that investigate various aspects dissection. conclusion, present discourse future perspectives, encompassing disease modeling, numerical challenges, clinical applications, particular focus The aspiration inspire studies, deepen comprehension disease, ultimately shape care treatment decisions.

Язык: Английский

Integrating Microstructure and Mechanics: An analysis of Multiscale Computational Models in Arterial Disease

Archives of Computational Methods in Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Язык: Английский