International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10041 - 10041
Опубликована: Сен. 18, 2024
The objective of this review is to provide a comprehensive examination the role microbial metabolites in progression neurodegenerative diseases, as well investigate potential therapeutic interventions targeting microbiota. A literature search was conducted across following databases: PubMed, Scopus, Web Science, ScienceDirect, and Wiley. Key terms related gut microbiota, metabolites, specific metabolic products were used. included both preclinical clinical research articles published between 2000 2024. Short-chain fatty acids have been demonstrated play crucial modulating neuroinflammation, preserving integrity blood–brain barrier, influencing neuronal plasticity protection. Furthermore, amino their derivatives exert significant influence on CNS function. These impact health by regulating intestinal permeability, immune responses, directly neuroinflammation oxidative stress, which are integral diseases. Therapeutic strategies, including prebiotics, probiotics, dietary modifications, fecal microbiota transplantation confirmed restore balance enhance production neuroprotective metabolites. novel drug developments based present promising avenues. its represent field with advance our understanding develop treatments for
Язык: Английский