Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 270 - 270
Опубликована: Фев. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Язык: Английский
Brain Glycogen—Its Metabolic Role in Neuronal Health and Neurological Disorders—An Extensive Narrative Review
Metabolites,
Год журнала:
2025,
Номер
15(2), С. 128 - 128
Опубликована: Фев. 13, 2025
Background:
Brain
glycogen
is
imperative
for
neuronal
health,
as
it
supports
energy
demands
and
metabolic
processes.
This
review
examines
the
pathways
involved
in
storage
utilization
central
nervous
system,
emphasizing
their
role
both
physiology
pathology.
It
explores
how
alterations
metabolism
contribute
to
neurological
disorders,
including
neurodegenerative
diseases,
epilepsy,
conditions
while
highlighting
bidirectional
interaction
between
neurons
glia
maintaining
brain
homeostasis.
Methods:
A
comprehensive
search
of
articles
published
2015
2025
was
conducted
using
following
databases:
ScienceDirect,
Scopus,
Wiley,
Web
Science,
Medline,
PubMed.
The
selection
relevant
studies
based
on
focus
its
conditions,
with
that
did
not
meet
inclusion
criteria
being
excluded.
Results:
processes
are
subject
rigorous
regulation
by
astrocyte-neuron
interactions,
thereby
ensuring
homeostasis
availability.
dysregulation
mobilization
has
been
implicated
development
synaptic
dysfunction,
excitotoxicity,
neurodegeneration
a
variety
disorders.
For
instance,
aberrant
accumulation
diseases
such
Lafora
disease
associated
severe
neurodegeneration,
impaired
shown
exacerbate
deficits
Alzheimer's
epilepsy.
Conclusions:
Targeting
represents
promising
approach
therapeutic
intervention
However,
translation
these
strategies
human
models
remains
challenging,
particularly
regard
long-term
safety
specificity
glycogen-targeted
therapies.
Язык: Английский
Role of the Intestinal Microbiota in the Molecular Pathogenesis of Atypical Parkinsonian Syndromes
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 3928 - 3928
Опубликована: Апрель 22, 2025
The
role
of
the
intestinal
microbiota
and
its
influence
on
neurodegenerative
disorders
has
recently
been
extensively
explored,
especially
in
context
Parkinson’s
disease
(PD).
In
particular,
immunomodulation,
impact
inflammation,
participation
gut–brain
axis
are
under
ongoing
investigations.
Recent
studies
have
revealed
new
data
that
could
be
important
for
exploring
neurodegeneration
mechanisms
connected
with
gut
microbiota,
potentially
leading
to
development
methods
treatment.
this
review,
potential
roles
future
disease-modifying
therapies
were
discussed
properties
microbiota—including
impacts
metabolism
short-chain
fatty
acids
vitamins—were
summarized,
a
particular
focus
atypical
Parkinsonian
syndromes.
This
review
focused
detailed
description
numerous
through
which
influences
processes.
explored
connections
between
evolution
progression
Finally,
derived
results
regarding
alterations
syndromes
comparison
previously
described
PD
was
also
included.
Язык: Английский
Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer’s, Parkinson’s, and ALS
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12613 - 12613
Опубликована: Ноя. 24, 2024
Neurodegenerative
diseases,
such
as
Alzheimer's,
Parkinson's,
ALS,
and
Huntington's,
remain
formidable
challenges
in
medicine,
with
their
relentless
progression
limited
therapeutic
options.
These
diseases
arise
from
a
web
of
molecular
disturbances-misfolded
proteins,
chronic
neuroinflammation,
mitochondrial
dysfunction,
genetic
mutations-that
slowly
dismantle
neuronal
integrity.
Yet,
recent
scientific
breakthroughs
are
opening
new
paths
to
intervene
these
once-intractable
conditions.
This
review
synthesizes
the
latest
insights
into
underlying
dynamics
neurodegeneration,
revealing
how
intertwined
pathways
drive
course
diseases.
With
an
eye
on
most
promising
advances,
we
explore
innovative
therapies
emerging
cutting-edge
research:
nanotechnology-based
drug
delivery
systems
capable
navigating
blood-brain
barrier,
gene-editing
tools
like
CRISPR
designed
correct
harmful
variants,
stem
cell
strategies
that
not
only
replace
lost
neurons
but
foster
neuroprotective
environments.
Pharmacogenomics
is
reshaping
treatment
personalization,
enabling
tailored
align
individual
profiles,
while
diagnostics
biomarkers
ushering
era
early,
precise
disease
detection.
Furthermore,
novel
perspectives
gut-brain
axis
sparking
interest
mounting
evidence
suggests
microbiome
modulation
may
play
role
reducing
neuroinflammatory
responses
linked
neurodegenerative
progression.
Taken
together,
advances
signal
shift
toward
comprehensive,
personalized
approach
could
transform
care.
By
integrating
techniques,
this
offers
forward-looking
perspective
future
where
treatments
aim
just
manage
symptoms
fundamentally
alter
progression,
presenting
renewed
hope
for
improved
patient
outcomes.
Язык: Английский