Nrf2 Signaling Pathway Studies in Drosophila melanogaster : Parallel Roles in Human Health and Insect Environmental Responses

Xenobiotica, Год журнала: 2025, Номер unknown, С. 1 - 30

Опубликована: Фев. 11, 2025

The Nrf2 signaling pathway is crucial for cellular defense against oxidative stress and xenobiotic toxicity, highlighting its importance in both human health environmental responses.

Язык: Английский

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Dimethylmonothioarsinic Acid (DMMTAV) Induces NQO1 Expression Through Coordinated Activation of NRF2 and AHR Pathways

Environmental Toxicology and Pharmacology, Год журнала: 2025, Номер unknown, С. 104674 - 104674

Опубликована: Март 1, 2025

Dimethylmonothioarsinic acid (DMMTAV), a potent toxic metabolite of arsenic, exhibits higher cytotoxicity than other arsenicals. This study investigates its influence on NAD(P)H:quinone oxidoreductase (NQO1) regulation in C57BL/6 mice and Hepa-1c1c7 cells. Mice were administered DMMTAV (6mg/kg, IP) with or without TCDD (15µg/kg, IP), hepatic extrahepatic tissues analyzed for NQO1 expression. In vitro, cells treated 0-2µM the presence absence (1nM), levels assessed over time. Western blot, real-time PCR, ARE-luciferase assays determined protein transcriptional regulation. upregulated liver induced time-dependent increase peaking at 12hours. It enhanced TCDD-induced expression increased nuclear NRF2 AHR levels, peak accumulation two hours. activity confirmed activation. These findings reveal enhances primarily via NRF2/AHR pathway activation, providing insight into cellular responses to thioarsenicals.

Язык: Английский

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Polydatin Mitigates Lead-Induced Nephropathy by Modulating Oxidative Stress, Inflammation, and the AMPK/AKT/Nrf2 Pathway in Rats

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Язык: Английский

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Lentinan alleviates cadmium‐induced kidney injury by reducing cadmium accumulation via promoting cadmium excretion and metallothionein synthesis and regulating silencing information regulator1/nuclear factor erythroid 2–related factor 2/nuclear factor kappa‐B signaling pathway

Journal of Food Science, Год журнала: 2025, Номер 90(3)

Опубликована: Март 1, 2025

Cadmium (Cd) is a widely distributed environmental heavy metal pollutant. It extremely toxic to the kidney. This study investigated potential mechanisms of action lentinan (LNT), fungal polysaccharide, on protecting against Cd-induced kidney injury in mice. Male Kunming mice were administered with CdCl2 (2.5 mg/kg/b.w.) by intragastric gavage and LNT drinking water (1 mg/mL) for 10 weeks. Histological examination revealed that reduced glomerular atrophy, lymphocyte infiltration, tubular congestion, collagen accumulation caused Cd exposure. However, oral administration decreased levels promoting excretion feces increasing production metallothionein (MT) In addition, treatment alleviated excessive mitophagy upregulating silencing information regulator1 (SIRT1) prevented subsequent oxidative stress inflammatory responses nuclear factor erythroid 2-related 2 (Nrf2) downregulating kappa-B (NF-κB) signaling pathways. Further, protein expression profibrotic factors, including Tgf-β1, alpha smooth muscle actin, type I 1 chain, progression fibrosis, significantly kidneys treated LNT. Collectively, our findings suggest can relieve nephrotoxicity decreasing its via MT synthesis regulating SIRT1/Nrf2/NF-κB pathway.

Язык: Английский

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Alleviating effect of antioxidants on combined chromium and cadmium-induced neurotoxicity and apoptosis by activating the Nrf2-keap1 and associated pathway in Swiss albino mice

Metabolic Brain Disease, Год журнала: 2025, Номер 40(4)

Опубликована: Апрель 4, 2025

Язык: Английский

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Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during should be studied. applications ensure commercial availability of normal karyotype human primary toxicity assessment hMSCs could serve as alternatives immortalized cell models. In this work, we evaluated the potential testing using inorganic arsenic (iAs) a case study. were exposed iAs at different durations track cellular aging study stability. exposures (48 h) resulted micronuclei induction. also 6 days determine if would become more susceptible chromosomal damage following exposure model genotoxicant, mitomycin C (MMC). The culture duration did not alter MMC potency, indicating that susceptibility remained unchanged. We used gene expression analysis investigate molecular impacts on over course short (3 total) long (30 experiments. Both activated biomarkers associated with oxidative stress, but direct DNA damage, providing support an indirect mode action genotoxicity. Overall, establishes utility new screening provides mechanistic information underlying toxicity.

Язык: Английский

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Effectiveness of Dipteryx alata Vog. in modulating anxiety, metabolic health, and reproductive parameters in rats treated during pregnancy and lactation

Brain Research, Год журнала: 2025, Номер unknown, С. 149639 - 149639

Опубликована: Апрель 1, 2025

Язык: Английский

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Regulation of macrophage polarization and pyroptosis by 4-methylcatechol alleviates collagen-induced arthritis via Nrf2/HO-1 and NF-κB/NLRP3 signaling pathways

International Immunopharmacology, Год журнала: 2024, Номер 146, С. 113855 - 113855

Опубликована: Дек. 21, 2024

Язык: Английский

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Anti-oxidant and anti-inflammatory action of calorie restriction and quercetin in two age groups of rats: Involvement of thioredoxin and heme oxygenase-1

Human Gene, Год журнала: 2024, Номер unknown, С. 201363 - 201363

Опубликована: Ноя. 1, 2024

Язык: Английский

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