Transition to Advanced Heart Failure: From Identification to Improving Prognosis
Journal of Cardiovascular Development and Disease,
Год журнала:
2025,
Номер
12(3), С. 104 - 104
Опубликована: Март 17, 2025
Advanced
heart
failure
(AHF)
represents
the
terminal
stage
of
(HF),
characterized
by
persistent
symptoms
and
functional
limitations
despite
optimal
guideline-directed
medical
therapy
(GDMT).
This
review
explores
clinical
definition,
pathophysiology,
therapeutic
approaches
for
AHF.
Characterized
severe
symptoms,
New
York
Heart
Association
(NYHA)
class
III-IV,
significant
cardiac
dysfunction,
frequent
hospitalizations,
AHF
presents
substantial
challenges
in
prognosis
management.
Pathophysiological
mechanisms
include
neurohormonal
activation,
ventricular
remodeling,
systemic
inflammation,
leading
to
reduced
output
organ
dysfunction.
Therapeutic
strategies
involve
a
multidisciplinary
approach,
including
pharmacological
treatments,
device-based
interventions
like
assisted
devices,
advanced
options
such
as
transplantation.
Despite
progress,
management
faces
limitations,
disparities
access
care
need
personalized
approaches.
Novel
therapies,
artificial
intelligence,
remote
monitoring
technologies
offer
future
opportunities
improve
outcomes.
Palliative
care,
which
focuses
on
symptom
relief
quality
life,
remains
crucial
patients
ineligible
invasive
interventions.
Early
identification
timely
intervention
are
pivotal
enhancing
survival
outcomes
this
vulnerable
population.
underscores
necessity
integrating
innovative
technologies,
medicine,
robust
palliative
into
address
its
high
morbidity
mortality.
Язык: Английский
Acute Hemodynamic Changes Induced by Cardiac Contractility Modulation Evaluated Using the NICaS® System: A Pilot Study
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2172 - 2172
Опубликована: Март 22, 2025
Background/Objectives:
Heart
failure
(HF)
with
reduced
ejection
fraction
remains
a
significant
global
health
challenge
despite
advances
in
medical
therapy.
Cardiac
contractility
modulation
(CCM)
is
promising
treatment
for
symptomatic
HF
patients
who
are
ineligible
cardiac
resynchronization
therapy
(CRT).
Non-invasive
methods
to
assess
the
acute
hemodynamic
effects
of
CCM
critical
optimize
care
and
guide
treatment.
This
study
aimed
evaluate
impact
on
stroke
volume
(SV)
total
peripheral
resistance
index
(TPRI)
using
non-invasive
bioimpedance-based
system
(NICaS®).
Methods:
Eight
(median
age:
64.6
years,
median
left
(LVEF):
34.5%)
underwent
implantation
Optimizer
Smart
Mini
device.
Hemodynamic
parameters,
including
SV
TPRI,
were
measured
NICaS®
at
baseline
(pre-implantation)
1
week,
month,
3
months
post-implantation.
Measurements
repeated
eight
times
per
session
analyzed
non-parametric
statistical
tests,
Kruskal-Wallis
test,
Mann-Whitney
Kolmogorov-Smirnov
test.
Results:
Median
increased
significantly
from
40.02
mL
(interquartile
range
(IQR):
32.62-78.16
mL)
69.83
(IQR:
58.63-86.36
(p
<
0.0001).
TPRI
decreased
2537
dn
s/cm5
m2
1807-3084
m2)
1307
1119-1665
over
same
period
improved
within
three
implantation.
Conclusions:
provided
reliable,
tool
monitoring
these
changes,
supporting
its
use
clinical
practice.
Язык: Английский
Therapie mit kardialen elektronischen implantierbaren Devices
Herz,
Год журнала:
2024,
Номер
49(3), С. 233 - 246
Опубликована: Май 6, 2024
Cardiac contractility modulation in patients with heart failure: the added value of cardiac rehabilitation in identification, management, and follow-up
International Journal of Cardiology Cardiovascular Risk and Prevention,
Год журнала:
2024,
Номер
21, С. 200284 - 200284
Опубликована: Май 16, 2024
Язык: Английский
Revisiting the diagnostic and prognostic significance of high-frequency QRS analysis in cardiovascular diseases: a comprehensive review
Postgraduate Medical Journal,
Год журнала:
2024,
Номер
100(1189), С. 785 - 795
Опубликована: Май 25, 2024
Cardiovascular
diseases
(CVDs)
present
a
significant
global
public
health
threat,
contributing
to
substantial
number
of
cases
involving
morbidity
and
mortality.
Therefore,
the
early
accurate
detection
CVDs
plays
an
indispensable
role
in
enhancing
patient
outcomes.
Decades
extensive
research
on
electrocardiography
at
high
frequencies
have
yielded
wealth
knowledge
regarding
alterations
QRS
complex
during
myocardial
ischemia,
as
well
methodologies
assess
quantify
these
changes.
In
recent
years,
analysis
high-frequency
(HF-QRS)
components
has
emerged
promising
non-invasive
approach
for
diagnosing
various
cardiovascular
conditions.
Alterations
HF-QRS
amplitude
morphology
demonstrated
remarkable
sensitivity
diagnostic
indicators
often
surpassing
measures
ST-T
segment
This
comprehensive
review
aims
provide
intricate
overview
current
advancements,
challenges,
prospects
associated
with
field
CVDs.
Язык: Английский
Beyond Medical Therapy—An Update on Heart Failure Devices
Journal of Cardiovascular Development and Disease,
Год журнала:
2024,
Номер
11(7), С. 187 - 187
Опубликована: Июнь 23, 2024
Heart
failure
(HF)
is
a
complex
and
progressive
disease
marked
by
substantial
morbidity
mortality
rates,
frequent
episodes
of
decompensation,
reduced
quality
life
(QoL),
with
severe
financial
burden
on
healthcare
systems.
In
recent
years,
several
large-scale
randomized
clinical
trials
(RCTs)
have
widely
expanded
the
therapeutic
armamentarium,
underlining
additional
benefits
feasibility
rapid
titration
regimens.
This
notwithstanding,
not
declining,
hospitalizations
are
constantly
increasing.
It
acknowledged
that
even
guideline-directed
medical
therapy
(GDMT)
board,
HF
patients
prohibitive
residual
risk,
which
highlights
need
for
innovative
treatment
options.
this
scenario,
groundbreaking
devices
targeting
valvular,
structural,
autonomic
abnormalities
become
crucial
tools
in
management.
has
led
to
full-fledged
translational
boost
novel
development.
Thus,
aim
review
provide
an
update
both
approved
investigated
devices.
Язык: Английский
Cardiac Replacement Therapy: critical issues and future perspectives of Heart Transplantation and Artificial Heart.
Current Problems in Cardiology,
Год журнала:
2024,
Номер
50(3), С. 102971 - 102971
Опубликована: Дек. 18, 2024
Язык: Английский
Response to levosimendan predicts response to cardiac contractility modulation therapy: a pilot study
Revista Española de Cardiología (English Edition),
Год журнала:
2024,
Номер
77(8), С. 703 - 705
Опубликована: Март 7, 2024
Язык: Английский
La respuesta a levosimendán predice la respuesta a la terapia de modulación de la contractilidad cardiaca: un estudio piloto
Revista Española de Cardiología,
Год журнала:
2024,
Номер
77(8), С. 703 - 705
Опубликована: Апрель 9, 2024
Editorial: Electrical management of heart failure: shaping the future of cardiac pacing and electrophysiology
Frontiers in Cardiovascular Medicine,
Год журнала:
2023,
Номер
10
Опубликована: Ноя. 2, 2023
EDITORIAL
article
Front.
Cardiovasc.
Med.,
02
November
2023Sec.
Cardiac
Rhythmology
Volume
10
-
2023
|
https://doi.org/10.3389/fcvm.2023.1325989
Язык: Английский