Long-Term Oncologic Outcomes of Off-Clamp Robotic Partial Nephrectomy for Cystic Renal Tumors: A Propensity Score Matched-Pair Comparison of Cystic versus Pure Clear Cell Carcinoma DOI Creative Commons

Mariaconsiglia Ferriero,

Alberto Ragusa, Riccardo Mastroianni

и другие.

Current Oncology, Год журнала: 2024, Номер 31(6), С. 2985 - 2993

Опубликована: Май 27, 2024

Few data are available on survival outcomes of partial nephrectomy performed for cystic renal tumors. We present the first long-term oncological (cystRCC) versus pure clear cell carcinoma (ccRCC) in a propensity score-matched (PSM) analysis. Our “renal cancer” prospectively maintained database was queried “cystRCC” or “ccRCC” and “off-clamp robotic nephrectomy” (off-C RPN). The two groups were compared age, gender, tumor size, pT stage, Fuhrman grade. A 1:3 PSM analysis applied to reduce covariate imbalance <10% homogeneous populations generated. Student t- Chi-square tests used continuous categorical variables, respectively. Ten-year between cohorts using log-rank test. Univariable Cox regression identify predictors disease progression after RPN. Out 859 off-C RPNs included, 85 cases cystRCC 774 ccRCC at histologic evaluation. After applying analysis, selected, including 64 170 ccRCC. Comparable 10-year cancer-specific probability (95.3% 100%, p = 0.146) found cohorts. Conversely, disease-free (DFS) less favorable than (66.69% 90.1%, 0.035). At univariable histology only independent predictor DFS (HR 2.96 95% CI 1.03–8.47, 0.044). evaluation, showed Pure variant displayed higher rate recurrence lesions.

Язык: Английский

Primary Adenocarcinoma of the Urinary Tract and Its Precursors: Diagnostic Criteria and Classification DOI

Fanni Sánta,

Mahmut Akgul,

Elie Tannous

и другие.

Human Pathology, Год журнала: 2025, Номер unknown, С. 105734 - 105734

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Diagnostic workout of glandular malignant lesions of the bladder according to the 5th WHO classification DOI

Francesca Sanguedolce,

Angelo Cormio,

Magda Zanelli

и другие.

Critical Reviews in Clinical Laboratory Sciences, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Март 9, 2025

Glandular lesions involving the bladder are less common than conventional urothelial carcinoma, and they often diagnostically challenging diseases, carrying different clinical outcomes. As a group, encompass both primary secondary neoplasms, with sometimes overlapping morphological features. In this scenario, proper information is important, in that involvement of may occur by direct extension or lymphatic/hematogenous spread from carcinomas at other sites, comprising prostate, colon, cervix, breast, lung. According to 5th edition WHO Classification urological tumors, glandular morphology major hallmark following entities: carcinoma differentiation, adenocarcinoma, NOS, urachal tumors Mullerian type. The distinction among these entities, between heavily relies on their biological immunophenotypical This article will review neoplasms bladder, highlighting main markers. Furthermore, molecular data associated pathogenesis, prognosis, treatment be described. aim study provide practical comprehensive up-to-date overview complex topic.

Язык: Английский

Процитировано

0
Application of RNA sequencing in urologic malignancies: Advances and challenges DOI
Khaleel I. Al‐Obaidy, Liang Cheng

Urologic Oncology Seminars and Original Investigations, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
From Bench to Bladder: The Rise in Immune Checkpoint Inhibition in the Treatment of Non-Muscle Invasive Bladder Cancer DOI Open Access
Cara C. Burns,

Jacob M. Parker,

Dylan M. Schaap

и другие.

Cancers, Год журнала: 2025, Номер 17(7), С. 1135 - 1135

Опубликована: Март 28, 2025

Non-muscle invasive bladder cancer (NMIBC) represents a significant clinical challenge due to its high recurrence rate and need for frequent monitoring. The current treatment modality is bacillus Calmette-Guérin (BCG) therapy combined with chemotherapy after transurethral resection of the tumor (TURBT), which highly effective in most patients. Yet, becomes resistant these treatments 30-40% patients, necessitating new modalities. In world, development immune checkpoint inhibitors that target molecules, such as programmed cell death protein-1 (PD-1), ligand, PD-L1, Cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), have revolutionized many types. PD-1/PD-L1 CTLA-4 are shown be upregulated NMIBC certain circumstances. interactions play role evasion by suppressing T activity within microenvironment (TME), while binding on cells leads downregulation response, making pathways potential immunotherapeutic targets NMIBC. This review seeks understand therapies treating We explore cellular non-cellular landscape TME NMIBC, including Tregs, effector cells, macrophages, B relevant cytokines. also discuss biological covering rationale immunotherapies Finally, we cover key trials studied clinically. Such study will helpful urologists oncologists manage patients more effectively.

Язык: Английский

Процитировано

0
Clinicopathologic and molecular characterization of primitive neuroectodermal tumors (PNET) in the female genital tract: a retrospective study of 8 cases DOI
Zhiyang Zhang,

Haiyan Shi,

Ying Shao

и другие.

Human Pathology, Год журнала: 2025, Номер unknown, С. 105769 - 105769

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
The percentage abundance of sarcomatoid component has a prognostic role in grade 4 non-metastatic clear cell-renal carcinoma DOI Creative Commons
Giuseppe Lucarelli, Francesco M. Lasorsa,

Monica Rutigliano

и другие.

World Journal of Urology, Год журнала: 2025, Номер 43(1)

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0
Multimodal deep learning model for predicting homologous recombination deficiency in prostate cancer: an international multi-cohort study DOI

Zijian Song,

Qianwen Zhang, Wenhui Zhang

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Abstract Accurate prediction of homologous recombination deficiency (HRD) status is crucial for effective management prostate cancer (PCa). However, genetic testing expensive and inaccessible. We propose a multimodal deep learning approach that integrates clinical information, Hematoxylin & Eosin (H&E)-stained whole-slide images (WSIs), multi-parameter MRI to predict the HRD patients with PCa. Patients from Cancer Genome Atlas (n = 387) three Chinese hospitals 179) were used establish validate models. The Pathology Signature, Radiology Patho-Radiology Signature could accurately in external validation or 5-fold cross (AUC 0.815, 0.833, 0.933, respectively). Notably, four interpretative pathological features identified Signature. These signatures serve as prescreening tool select confirmatory testing. suggest this multi-modal be applied molecular alterations other malignancies.

Язык: Английский

Процитировано

0
Applications and prospects of spatial transcriptomics in prostate cancer research: A narrative review DOI Creative Commons

Y. Jin,

Zhiming Bai, Gang Wang

и другие.

Current Urology, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Abstract Spatial transcriptomics, an increasingly prominent technique, has been extensively utilized to examine tumors within the digestive tract (such as liver and colorectal cancers) nervous system. However, its application in prostate cancer research remains comparatively limited. This article provides a detailed overview of principles features spatial particularly highlighting applications studying tumor microenvironment, heterogeneity, clinical implications cancer. Through systematic review analysis current literature, we identify main focus areas limitations existing on transcriptomics suggest potential future directions.

Язык: Английский

Процитировано

0
Genomic profiling of urological malignancies using tissue-based next generation sequencing DOI
Zainab Alruwaii, Gamze Gokturk Ozcan,

Oudai Hassan

и другие.

Urologic Oncology Seminars and Original Investigations, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Microsatellite instability and mismatch repair deficiency in bladder urothelial carcinoma: a Tunisian single-center study DOI Creative Commons

Ahlem Bdioui,

M. Akkari,

Maroua Krifa

и другие.

Journal of the Egyptian National Cancer Institute, Год журнала: 2025, Номер 37(1)

Опубликована: Май 25, 2025

Abstract Background Microsatellite instability (MSI) and deficiency in the human mismatch repair (MMR) system are critical drivers of genomic various cancers. Tumors exhibiting MSI MMR (dMMR) have prognostic implications associated with differential responses to immune checkpoint inhibitors. Given their key roles tumorigenesis, investigating protein expression urothelial cancer bladder is essential improve therapeutic strategies deepen understanding its molecular features. This study aimed assess primary carcinoma evaluate associations clinicopathological characteristics. Methods A total 49 carcinomas were analyzed for using immunohistochemistry, dMMR tumors underwent further analysis status markers Bethesda panel (BAT25, BAT26, D2S123, D5S346, D17S250). The findings parameters. Results was identified two high-grade (4.1%), while remaining cases demonstrated proficient MMR. Both showed impaired immunoreactivity, one tumor displaying a simultaneous loss MLH1/PMS2 heterodimer other showing isolated MSH6 loss. revealed BAT26 MLH1/PMS2-deficient at D17S250 MSH6-deficient tumor. exhibited low-level (MSI-L). No relevant found between MMR/MSI features ( p > 0.05). Conclusions identification MSI-L only samples underscores rarity among Tunisian patients. These emphasize need larger, multi-center studies elucidate MSI/dMMR clinical carcinoma.

Язык: Английский

Процитировано

0