Current Opinion in Lipidology,
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 29, 2023
Purpose
of
review
The
aims
to
explore
the
recent
evidence
on
associations
between
different
dietary
fat
intake
and
cognitive
function,
understand
role
telomere
length
in
this
relationship.
Recent
findings
Clinical
preclinical
studies
included
suggest
that
is
associated
with
function
length.
High
saturated
fats
trans
fats,
commonly
found
ultra-processed
foods,
appears
have
negative
effects
length,
while
other
such
as
omega-3
polyunsaturated
fatty
acids
monounsaturated
are
improved
performance
reduced
attrition.
Controversial
results
related
omega-6
its
impact
were
found.
Dietary
may
affect
cognition
through
oxidative
stress,
inflammation,
insulin
resistance.
Summary
current
illustrated
relationship
by
focusing
a
potential
intermediator.
More
future
required,
however,
order
develop
targeted
interventions
aimed
at
preserving
well-being
throughout
life.
Diabetes-related
cognitive
impairment
is
increasingly
recognized
as
a
significant
complication,
profoundly
impacting
patients'
quality
of
life.
This
review
aims
to
examine
the
pathophysiological
mechanisms,
clinical
manifestations,
risk
factors,
assessment
and
diagnosis,
management
strategies,
future
research
directions
in
diabetes.
A
comprehensive
literature
search
was
conducted
using
PubMed,
Medline,
other
medical
databases
identify,
review,
evaluate
published
articles
on
The
focused
studies
examining
pathophysiology,
presentations,
diagnostic
approaches,
strategies.
current
revealed
that
chronic
hyperglycemia,
insulin
resistance,
vascular
factors
are
major
contributing
deficits
Clinical
manifestations
include
impairments
attention,
memory,
executive
function,
visuospatial
abilities,
language.
Risk
encompass
disease
duration,
glycemic
control,
presence
complications,
age,
education
level,
comorbidities.
Assessment
tools
screening
instruments,
neuropsychological
testing,
neuroimaging
techniques.
Management
strategies
involve
control
optimization,
lifestyle
modifications,
training,
pharmacological
interventions.
highlights
prevalence
impact
diabetes,
resulting
from
complex
metabolic
disturbances.
Early
detection
multifaceted
interventions
crucial
for
preserving
function
improving
patient
outcomes.
Future
should
focus
neuroprotective
biomarker
identification,
personalized
approaches.
Collaborative
efforts
between
clinicians
researchers
essential
effectively
address
this
growing
healthcare
challenge
enhance
life
individuals
with
diabetes-related
impairment.
Alzheimer s & Dementia,
Год журнала:
2025,
Номер
21(2)
Опубликована: Фев. 1, 2025
Cognition
is
reduced
at
low
and
high
glucose,
reflecting
cognitive
vulnerability
to
glucose
(CVG)
fluctuations.
The
impact
of
fluctuations
on
the
aging
brain
remains
unclear.
We
examined
whether
CVG
associated
with
plasma
biomarkers
Alzheimer's
disease
(AD)
pathology
neurodegeneration.
Participants
included
N
=
114
adults
type
1
diabetes
assessed
for
processing
speed
sustained
attention
using
ecological
momentary
assessment
(EMA)
combined
continuous
monitoring
(CGM).
characterized
associations
between
amyloid
beta
(Aβ)
42/40,
phosphorylated
tau
(p-tau)
181
217,
neurofilament
light
chain,
glial
fibrillary
acidic
protein.
was
all
biomarkers,
except
Aβ
42/40.
exhibited
strong
p-tau
that
persisted
across
covariate
specifications.
may
be
a
useful
digital
phenotype
AD.
It
unclear
contributes
versus
arises
from
consider
possible
mechanisms
linking
long-term
variability
development
neuropathology.
Cognitive
used
investigate
CVG's
biomarkers.
Associations
remained
significant
covariates.
discuss
relating
variability,
cognition,
Foods,
Год журнала:
2025,
Номер
14(5), С. 870 - 870
Опубликована: Март 3, 2025
In
this
study,
the
impact
of
lentil
hull
soluble
dietary
fibers
(SDFs)
on
colitis
and
behavioral
deficits
in
mice
was
assessed.
Structural
characterizations
SDFs
confirmed
that
cellulase-modified
fiber
exhibited
better
physicochemical
properties:
more
porous
microstructure;
similar
polysaccharide
structure;
stable
particle
size
distribution;
higher
crystallinity;
adsorption
capacity;
lower
viscosity.
Additionally,
we
explored
its
potential
cognitive
benefits
via
gut-brain
axis
by
tests,
histopathology,
16S
rRNA
sequencing,
gas
chromatography
metabolomics
analysis.
The
results
showed
significantly
improved
inflammatory
symptoms
colon
brain
behaviors.
LSDF
had
efficacy
than
HSDF.
intervention
decreased
harmful
bacteria
abundance
(Bacteroides,
Flexispira
Escherichia,
etc.)
increased
beneficial
(Aggregatibacter
Helicobacter,
etc.).
also
affected
metabolites
through
sphingolipid
metabolism.
Spearman
correlation
analysis
there
a
positive
between
with
factors
(LPS,
IL-1β,
IL-6,
TNF-α,
metabolites,
while
were
positively
correlated
brain-derived
neurotrophic
factor
(BDNF),
IL-10,
behavior.
This
study
highlights
value
future
diet-based
therapeutic
strategies
targeting
interactions.
Journal of Epidemiology and Global Health,
Год журнала:
2023,
Номер
13(3), С. 566 - 576
Опубликована: Июль 3, 2023
Diabetes
is
a
life-long
disease
that
poses
serious
threat
to
safety
and
health.
We
aimed
assess
the
burden
attributable
diabetes
globally
by
different
subgroups,
predict
future
using
statistical
models.This
study
was
divided
into
three
stages.
Firstly,
we
evaluated
subgroups
in
2019.
Second,
assessed
trends
from
1990
estimated
annual
percentage
change
of
applying
linear
regression
model.
Finally,
age-period-cohort
model
used
2020
2044.
Sensitivity
analysis
performed
with
time-series
models.In
2019,
number
incidence
cases
22239396
(95%
uncertainty
interval
(UI):
20599519-24058945).
The
prevalence
459875371
UI
423474244-497980624)
deaths
1551170
1445555-1650675)
disability-adjusted
life
years
70880155
59707574-84174005).
lower
females
than
males
increased
age.
associated
type
2
mellitus
greater
1;
also
varied
across
socio-demographic
index
regions
countries.
global
significantly
over
past
30
will
continue
increase
future.The
contributed
burden.
It
important
improve
treatment
diagnosis
halt
growth
Chemistry & Biodiversity,
Год журнала:
2023,
Номер
20(6)
Опубликована: Апрель 17, 2023
Abstract
As
a
dietary
supplement,
the
efficacy
of
prebiotics
has
become
hot
issue
in
recent
years.
Inulin
is
one
internationally
recognized
and
belongs
to
group
non‐digestible
fermentable
carbohydrates.
Currently,
food
industry
increasingly
using
prebiotic
inulin
as
health‐promoting
substrate,
not
just
supplement.
In
addition,
also
shown
great
promise
treatment
various
diseases.
This
article
reviews
application
summarizes
physiological
function
inulin.
Through
review
prospect
research
on
obesity,
diabetes
mental
illness,
it
provides
theoretical
basis
for
joint
development
medical
application.
Abstract
Neurodegenerative
diseases
(NDs)
stand
for
a
group
of
disorders
characterized
by
the
progressive
loss
neurons
in
brain
and
peripheral
organs,
resulting
motor
cognitive
dysfunction.
The
global
prevalence
NDs,
including
Alzheimer's
disease,
Parkinson's
Huntington's
amyotrophic
lateral
sclerosis,
is
on
rise
globally,
primarily
due
to
an
aging
population,
positioning
NDs
as
increasing
significant
public
health
concern.
Despite
intensive
research,
few
effective
therapies
that
prevent
or
delay
ND
progression
have
been
developed.
Mounting
evidence
indicates
one
well‐defined
risk
factors
type
2
diabetes
mellitus,
insulin
resistance
has
also
proven
be
related
decline.
Certain
antidiabetic
drugs,
such
glucagon‐like
peptide‐1
receptor
agonists,
peroxisome
proliferator‐activated
gamma
metformin,
shown
promise
offering
neuroprotective
benefits
alleviating
symptoms
beyond
their
glucose‐lowering
effects.
Although
exact
mechanisms
remain
elusive,
these
drugs
offer
promising
novel
strategy
managing
disorders.
In
this
review,
we
first
highlight
specific
effects
multiple
discuss
main
action
treating
NDs.
These
include
reducing
protein
aggregation
improving
apoptosis,
mitochondrial
dysfunction,
oxidative
stress,
neuroinflammation.
Finally,
summarize
clinical
trials
evaluating
Psychotic
depression
(PD)
is
a
highly
debilitating
disorder
characterized
by
hallucinations
and/or
delusions
accompanied
depression.
A
variety
of
neurotransmitters,
hormones
and
corresponding
receptors
in
the
endocrine
system
are
involved
onset
progression
depression,
fasting
blood
glucose
(FBG)
can
be
an
important
indicator
for
monitoring
stability
system.
The
aim
this
study
was
to
investigate
relationship
between
FBG
PD
Chinese
population
with
first-episode
drug-naïve
(FEDN)
major
depressive
(MDD).
In
study,
1718
outpatient
individuals
diagnosed
(FEDN
MDD)
were
included.
association
levels
identified
through
multivariable
binary
logistic
regression
analysis.
To
potential
non-linear
relationships,
two-piecewise
linear
model
utilized.
Additionally,
interaction
stratified
analyses
performed
based
on
gender,
educational
background,
marital
status,
presence
comorbid
anxiety,
history
suicide
attempt.
Multivariate
analysis
showed
that
positively
associated
risk
FEDN
MDD
patients
(OR
=
1.68,
95%
CI:
1.31
2.13;
P
<
0.05).
Smoothed
plots
PD,
while
inflection
point
calculated
using
two-segmented
6.23
mmol/L.
On
right
side
point,
probability
increased
substantially
278%
3.78,
1.75
8.18,
p
0.001),
no
significant
observed
left
1.06,
0.73
1.52,
0.772).
Our
investigation
revealed
nonlinear
MDD,
thereby
informing
more
effective
intervention
strategies
managing
psychotic
symptoms
