Appraising the life‐course impact of Epstein‐Barr virus exposure and its genetic signature on periodontitis
Journal of Periodontology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
Abstract
Background
Periodontitis
arises
from
a
multifaceted
interplay
of
environmental
variables
and
genetic
susceptibility,
where
microbial
infection
plays
an
indispensable
part.
Epstein‐Barr
virus
(EBV)
exposure
has
long
been
considered
associated
with
periodontitis
activity;
however,
the
causal
relationship
connection
between
them
remain
unknown.
Methods
Within
life‐course
context,
our
study
employed
comprehensive
Mendelian
randomization
(MR)
methods,
including
univariable,
multivariable,
Bayesian
model
averaging,
reverse
MR,
to
investigate
association
EBV
periodontitis.
Additionally,
linkage
disequilibrium
score
regression
colocalization
analysis
were
utilized
assess
cross‐trait
correlations,
followed
by
transcriptome‐wide
enrichment
discern
genetic‐phenotypic
biological
profiles.
Results
Heightened
levels
antibodies,
particularly
early
antigen
diffuses
(which
serve
as
indicators
or
reactivation),
are
increased
risk
(odds
ratio
[OR]:
1.27
[1.09–1.47],
p
=
6.05
×
10
−3
)
demonstrate
significant
correlation
(
4.11
).
This
pathogenesis
may
involve
high‐confidence
gene
RNASEK
located
in
17p13.1.
Genetically
predicted
early‐life
anti‐EBV
immunoglobulin
G
(IgG)
correlated
reduced
(OR:
0.89
[0.82–0.97],
1.76
Conclusions
The
present
highlights
impact
its
hallmark
on
periodontitis,
providing
novel
perspectives
into
underlying
management
strategies
for
EBV‐related
These
findings
underscore
diverse
clinical
public
health
implications,
encompassing
antiviral
therapies,
viral
vaccination
strategies,
tailored
interventions
individualized
management.
Further
research
is
required
validate
expand
upon
findings.
Plain
Language
Summary
chronic
inflammatory
disease
driven
interactions
pathogens
host
immune
system.
While
bacteria
have
traditionally
focus
research,
recent
studies
highlight
significance
virus‐bacteria
interactions,
role
(EBV)—a
herpesvirus
infecting
over
90%
global
population—in
development
However,
mechanisms
unclear.
Our
genome‐wide
multi‐omics
approaches
link
We
found
that
reactivation
increases
whereas
exposure,
possibly
enabling
resistance,
reduce
it.
Essential
genes
identified
potential
mediators,
CRTC3‐AS1
,
HLA‐DQA1
.
provide
insights
EBV‐periodontitis
connection.
For
example,
testing
control
could
benefit
patients
unresponsive
standard
bacterial
treatments,
via
might
elucidate
these
contribution
interactions.
Язык: Английский
Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014
Journal of Medical Virology,
Год журнала:
2024,
Номер
96(7)
Опубликована: Июль 1, 2024
Abstract
Periodontitis
is
a
cumulative
inflammatory
disease
associated
with
multiple
health
conditions
and
various
systemic
diseases.
As
common
disease,
virus
infection
along
its
consequences
has
become
serious
burden.
The
study
aims
to
evaluate
the
relationship
between
viruses
including
hepatitis
virus,
human
immunodeficiency
(HIV),
herpes
simplex
(HSV),
papillomavirus
(HPV),
periodontitis.
data
from
US
National
Health
Nutrition
Examination
Survey
(NHANES)
2009−2014
was
adopted
screened
through,
10
714
participants.
Generalized
linear
regression
conducted
verify
relationships
infections
Moreover,
we
also
performed
analyses
in
age
gender
subgroups.
results
suggested
that
of
HCV,
HSV‐1,
HSV‐2
significantly
prevalence
periodontitis
(odds
ratio
[OR]
1.46,
95%
confidence
interval
[CI]
1.26−1.70;
OR
1.09,
CI
1.05−1.13;
1.06,
1.01
‐
1.11,
respectively)
risk
developing
moderate
or
severe
(OR
1.51,
1.29−1.77;
1.08,
1.04−1.12;
1.05,
1.01−1.10,
after
adjusting
all
relevant
co‐factors.
Subgroup
revealed
steady
association
C
(HCV)
HSV‐1
infection,
while
HPV
can
be
found
some
presence
HCV
HSV
periodontitis,
cases.
observed
people
<
35
years.
Язык: Английский