Hydrogels: Classifications, fundamental properties, applications, and scopes in recent advances in tissue engineering and regenerative medicine – A comprehensive review

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(10), С. 105968 - 105968

Опубликована: Авг. 17, 2024

Hydrogels are three-dimensional structures that serve as substitutes for the extracellular matrix (ECM) and possess outstanding physicochemical biochemical characteristics. They gaining importance in regenerative medicine because of their similarity to natural terms moisture content wound tissue healing permeability. Tissue engineering advancements have resulted development flexible hydrogels mimic dynamic characteristics ECM. Several approaches been applied produce from biopolymers with enhanced functional structural different applications (TERM). This review provides a comprehensive overview hydrogel healing, engineering, drug delivery systems. We outline types based on physical chemical crosslinking, fundamental properties, TERM. article provided recent literature within five years. Recent developments biopolymer-based state-of-the-art discussed, emphasizing significant challenges future perspectives.

Язык: Английский

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Lutein-loaded multifunctional hydrogel dressing based on carboxymethyl chitosan for chronic wound healing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140219 - 140219

Опубликована: Янв. 1, 2025

Язык: Английский

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Alginate based polymeric systems for drug delivery, antibacterial/microbial, and wound dressing applications

Materials Today Communications, Год журнала: 2022, Номер 33, С. 104813 - 104813

Опубликована: Окт. 31, 2022

Язык: Английский

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Thermo-Sensitive Poly (N-isopropylacrylamide-co-polyacrylamide) Hydrogel for pH-Responsive Therapeutic Delivery

Polymers, Год журнала: 2022, Номер 14(19), С. 4128 - 4128

Опубликована: Окт. 2, 2022

Stimuli-response polymeric nanoparticles have emerged as a carrier system for various types of therapeutic delivery. In this study, we prepared dual pH- and thermo-sensitive copolymer hydrogel (HG) (PNIPAm-co-PAAm HG), using N-isopropyl acrylamide (NIPAm) (AAm) comonomers. The synthesized PNIPAm-co-PAAm HG was characterized instrumental characterizations. Moreover, the HG's thermoresponsive phase transition behavior investigated, results showed that responds to temperature changes. vitro drug loading release investigated Curcumin (Cur) model cargo under different pH conditions. temperature-responsive demonstrated about 65% Cur efficiency. A nearly complete loaded occurred from over 4 h at 5.5 40 °C. cytotoxicity study performed on liver cancer cell line (HepG2 cells), which revealed good biocompatibility, suggesting it could be applied delivery carrier. in cytocompatibility test (MTT assay) is biocompatible. Therefore, has potential useful drugs solid tumor-targeted therapy.

Язык: Английский

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Bioactive scaffold (sodium alginate)-g-(nHAp@SiO2@GO) for bone tissue engineering

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 222, С. 462 - 472

Опубликована: Сен. 23, 2022

Язык: Английский

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Sodium alginate-based drug delivery for diabetes management: A review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 236, С. 123986 - 123986

Опубликована: Март 10, 2023

Язык: Английский

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Hydrogel Tissue Bioengineered Scaffolds in Bone Repair: A Review

Molecules, Год журнала: 2023, Номер 28(20), С. 7039 - 7039

Опубликована: Окт. 12, 2023

Large bone defects due to trauma, infections, and tumors are difficult heal spontaneously by the body’s repair mechanisms have become a major hindrance people’s daily lives economic development. However, autologous allogeneic grafts, with their lack of donors, more invasive surgery, immune rejection, potential viral transmission, hinder development repair. Hydrogel tissue bioengineered scaffolds gained widespread attention in field good biocompatibility three-dimensional network structure that facilitates cell adhesion proliferation. In addition, loading natural products nanoparticles incorporating them into hydrogel is one most effective strategies promote bioactivity limitations products. Therefore, this paper presents brief review application hydrogels different gel-forming properties, matrices, nanoparticle-loaded loaded incorporated for defect recent years.

Язык: Английский

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Medical Applications of Hydrogels in Skin Infections: A Review

Infection and Drug Resistance, Год журнала: 2023, Номер Volume 16, С. 391 - 401

Опубликована: Янв. 1, 2023

Skin infections are common diseases for which patients seek inpatient and outpatient medical care. Globally, an increasing number of people affected by skin that could lead to physical psychological damage. always have a broad spectrum clinical presentations require physicians make aggressive accurate diagnosis prescribing the proper symptomatic antimicrobials. In most instances, treatment mainly includes oral or topical anti-infective drugs. However, some classical drugs limitations, such as poor water solubility, low bioavailability, targeting efficiency, can efficacy, adverse effects, drug resistance. Therefore, research priorities should focus on development more effective delivery systems with new materials. Hydrogels highly multifunctional class materials potential applications in dermatology. Several hydrogel dressings functions been formulated demonstrated improve efficacy tolerance certain degree. this study, hydrogels various systematically reviewed provide important theoretical reference future studies options infections.

Язык: Английский

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Size-dependent cellular uptake of sodium alginate passivated tin dioxide nanoparticles in triple-negative breast cancer cells

Journal of Industrial and Engineering Chemistry, Год журнала: 2023, Номер 123, С. 476 - 487

Опубликована: Апрель 11, 2023

Язык: Английский

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Composite hydrogels fabricated from CMC-PVA-GG incorporated with ZiF-8 for wound healing applications

Journal of Biomaterials Science Polymer Edition, Год журнала: 2024, Номер 35(17), С. 2640 - 2659

Опубликована: Авг. 7, 2024

The skin is at risk for injury to external factors since it serves as the body's first line of defense against environment. Hydrogels have drawn much interest due their intrinsic extracellular matrix (ECM) properties and biomimetic, structural, durable mechanical characteristics. enormous potential use in wound healing ability deliver bioactive substances easily. In this study, composite hydrogels were developed by blending guar gum (GG), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) with crosslinker TEOS treatment. surface morphology, roughness, stability features characterized several techniques, such FTIR, SEM-EDX, AFM, DSC. increasing ZiF-8 causes more decreased swelling different media (Aqueous > PBS NaCl). amount less hydrophilic behavior biodegradation gel fraction. cytocompatibility Zinc imidazolate framework-8 (ZiF-8) based composites was evaluated fibroblast cell lines viability, proliferation, morphology. caused viability proliferation proper Hence, results show that synthesized may be a candidate numerous repair applications.

Язык: Английский

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