Spectroscopic, Hartree–Fock and DFT study of the molecular structure and electronic properties of functionalized chitosan and chitosan-graphene oxide for electronic applications DOI Creative Commons
Hanan Elhaes,

Hend A. Ezzat,

Asmaa Ibrahim

et al.

Optical and Quantum Electronics, Journal Year: 2024, Volume and Issue: 56(3)

Published: Jan. 27, 2024

Abstract Chitosan is a natural biopolymer that classified among the most important biodegradable polysaccharides widely used in different environmental and industrial applications, such as tissue engineering, biomedical devices, electronics supercapacitors, water filtration, food packaging. Theoretical infrared spectra of chitosan were computed using both Hartree–Fock (HF) Density Functional Theory (DFT) methods, with basis sets, including 3-21g, 6-31g, 6-311g, LANL2DZ, LANL2MB, to identify ideal set closest experimental results. DFT:B3LYP/3-21g** was best model for investigate its functionalization various functional groups (OH, NH 2 , COOH, CH 3 CHO, CN, SH) graphene oxide (GO). Molecular electrostatic potential, total dipole moment, HOMO–LUMO band gap ( ∆ E) calculations indicated Chitosan-GO reactive stable structure, E 0.3023 eV. Consequently, Chitosan–GO composite prepared analyzed ATR–FTIR spectroscopy. The revealed new at 1620 cm −1 which attributed COOH group GO red-shifted owing hydrogen bonding between chitosan, confirming synthesis composite. significant improvement electronic properties based on obtained results promotes it be applications development electrodes supercapacitors.

Language: Английский

Hydrogels: Classifications, fundamental properties, applications, and scopes in recent advances in tissue engineering and regenerative medicine – A comprehensive review DOI Creative Commons
Muhammad Umar Aslam Khan,

Muhammad Azhar Aslam,

Mohd Faizal Abdullah

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(10), P. 105968 - 105968

Published: Aug. 17, 2024

Hydrogels are three-dimensional structures that serve as substitutes for the extracellular matrix (ECM) and possess outstanding physicochemical biochemical characteristics. They gaining importance in regenerative medicine because of their similarity to natural terms moisture content wound tissue healing permeability. Tissue engineering advancements have resulted development flexible hydrogels mimic dynamic characteristics ECM. Several approaches been applied produce from biopolymers with enhanced functional structural different applications (TERM). This review provides a comprehensive overview hydrogel healing, engineering, drug delivery systems. We outline types based on physical chemical crosslinking, fundamental properties, TERM. article provided recent literature within five years. Recent developments biopolymer-based state-of-the-art discussed, emphasizing significant challenges future perspectives.

Language: Английский

Citations

20
Lutein-loaded multifunctional hydrogel dressing based on carboxymethyl chitosan for chronic wound healing DOI
Hongyan Zhang, Xin Gao, Wei Dai

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140219 - 140219

Published: Jan. 1, 2025

Language: Английский

Citations

3
Alginate based polymeric systems for drug delivery, antibacterial/microbial, and wound dressing applications DOI

Vinayak Hegde,

U.T. Uthappa, Tariq Altalhi

et al.

Materials Today Communications, Journal Year: 2022, Volume and Issue: 33, P. 104813 - 104813

Published: Oct. 31, 2022

Language: Английский

Citations

69
Thermo-Sensitive Poly (N-isopropylacrylamide-co-polyacrylamide) Hydrogel for pH-Responsive Therapeutic Delivery DOI Open Access
Madhappan Santhamoorthy, Thi Tuong Vy Phan, V. Ramkumar

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(19), P. 4128 - 4128

Published: Oct. 2, 2022

Stimuli-response polymeric nanoparticles have emerged as a carrier system for various types of therapeutic delivery. In this study, we prepared dual pH- and thermo-sensitive copolymer hydrogel (HG) (PNIPAm-co-PAAm HG), using N-isopropyl acrylamide (NIPAm) (AAm) comonomers. The synthesized PNIPAm-co-PAAm HG was characterized instrumental characterizations. Moreover, the HG's thermoresponsive phase transition behavior investigated, results showed that responds to temperature changes. vitro drug loading release investigated Curcumin (Cur) model cargo under different pH conditions. temperature-responsive demonstrated about 65% Cur efficiency. A nearly complete loaded occurred from over 4 h at 5.5 40 °C. cytotoxicity study performed on liver cancer cell line (HepG2 cells), which revealed good biocompatibility, suggesting it could be applied delivery carrier. in cytocompatibility test (MTT assay) is biocompatible. Therefore, has potential useful drugs solid tumor-targeted therapy.

Language: Английский

Citations

54
Bioactive scaffold (sodium alginate)-g-(nHAp@SiO2@GO) for bone tissue engineering DOI
Muhammad Umar Aslam Khan, Saiful Izwan Abd Razak, Sarish Rehman

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 222, P. 462 - 472

Published: Sept. 23, 2022

Language: Английский

Citations

49
Sodium alginate-based drug delivery for diabetes management: A review DOI
Mohammad Arshad Javed Shaikh, Gaurav Gupta, Obaid Afzal

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 236, P. 123986 - 123986

Published: March 10, 2023

Language: Английский

Citations

34
Hydrogel Tissue Bioengineered Scaffolds in Bone Repair: A Review DOI Creative Commons

Qiteng Ding,

Shuai Zhang, Xinglong Liu

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7039 - 7039

Published: Oct. 12, 2023

Large bone defects due to trauma, infections, and tumors are difficult heal spontaneously by the body’s repair mechanisms have become a major hindrance people’s daily lives economic development. However, autologous allogeneic grafts, with their lack of donors, more invasive surgery, immune rejection, potential viral transmission, hinder development repair. Hydrogel tissue bioengineered scaffolds gained widespread attention in field good biocompatibility three-dimensional network structure that facilitates cell adhesion proliferation. In addition, loading natural products nanoparticles incorporating them into hydrogel is one most effective strategies promote bioactivity limitations products. Therefore, this paper presents brief review application hydrogels different gel-forming properties, matrices, nanoparticle-loaded loaded incorporated for defect recent years.

Language: Английский

Citations

27
Size-dependent cellular uptake of sodium alginate passivated tin dioxide nanoparticles in triple-negative breast cancer cells DOI

Chandrasekaran Karthikeyan,

Kokkarachedu Varaprasad, Sungjun Kim

et al.

Journal of Industrial and Engineering Chemistry, Journal Year: 2023, Volume and Issue: 123, P. 476 - 487

Published: April 11, 2023

Language: Английский

Citations

24
Medical Applications of Hydrogels in Skin Infections: A Review DOI Creative Commons
Yan Teng, Sujing Li, Hui Tang

et al.

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 391 - 401

Published: Jan. 1, 2023

Skin infections are common diseases for which patients seek inpatient and outpatient medical care. Globally, an increasing number of people affected by skin that could lead to physical psychological damage. always have a broad spectrum clinical presentations require physicians make aggressive accurate diagnosis prescribing the proper symptomatic antimicrobials. In most instances, treatment mainly includes oral or topical anti-infective drugs. However, some classical drugs limitations, such as poor water solubility, low bioavailability, targeting efficiency, can efficacy, adverse effects, drug resistance. Therefore, research priorities should focus on development more effective delivery systems with new materials. Hydrogels highly multifunctional class materials potential applications in dermatology. Several hydrogel dressings functions been formulated demonstrated improve efficacy tolerance certain degree. this study, hydrogels various systematically reviewed provide important theoretical reference future studies options infections.

Language: Английский

Citations

23
Current progress of protein-based dressing for wound healing applications – A review DOI
Muhammad Umar Aslam Khan,

Muhammad Azhar Aslam,

Roselinda Ab Rahman

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: 35(15), P. 2402 - 2445

Published: July 17, 2024

Protein-based wound dressings have garnered increasing interest in recent years owing to their distinct physical, chemical, and biological characteristics. The intricate molecular composition of proteins gives rise unique characteristics, such as exceptional biocompatibility, biodegradability, responsiveness, which contribute the promotion healing. Wound healing is an ongoing process influenced by multiple causes, it consists four phases. Various treatments been developed repair different types skin wounds, thanks advancements medical technology recognition diverse nature wounds. This review has literature reviewed within last 3-5 years-the progress development protein fundamental properties ideal dressing. Herein, strides protein-based state-of-the-art dressing emphasize significant challenges summarize future perspectives for applications.

Language: Английский

Citations

10