Medicine, Год журнала: 2024, Номер 103(15), С. e37717 - e37717

Опубликована: Апрель 12, 2024

Cancer incidence is increasingly seen in younger individuals. Molecular distinctions between young and elderly patients at onset are understudied. This study used public databases to explore genomic, transcriptomic, immune-related features across age groups cervical cancer. Additionally, it aims create a prognostic model applicable diverse cohorts, enabling precise patient stratification, personalized therapies. Gene mutations, expression data, clinicopathological information were obtained from 317 cancer patients. These divided into group an old based on the median of onset. The characteristics differential gene mutation, expression, immune cells analysis analyzed by R software. Finally, was constructed univariate Cox, least absolute shrinkage selection operator, multivariate Cox regression analyses angiogenic sets. Its validity further confirmed using additional 300 squamous cell carcinoma endocervical adenocarcinoma tissues. Cervical exhibit significantly higher frequency NOTCH1 TP53 driver mutations compared patients, along with notably tumor mutational burden. However, there no significant differences 2 terms genomic instability age-related signatures. Differential revealed that upregulated interferon-alpha gamma responses exhibited activity multiple metabolic pathways. Immune microenvironment indicated enrichment dendritic natural killer group, while transforming growth factor-β signature enriched indicating degree exclusion. A multigene angiogenesis T sets showed excellent performance independent clinical factors such as age. High-risk identified activation tumor-promoting processes, metastasis angiogenesis. Our reveals distinct patterns cancer-driving mechanisms, biological system status findings shed light age-specific underlying mechanisms carcinogenesis. Furthermore, molecular provide valuable references for stratification development potential drug targets.

Язык: Английский