Starch - Stärke,
Год журнала:
2023,
Номер
76(11-12)
Опубликована: Сен. 11, 2023
Abstract
In
recent
years,
researchers
have
been
exploring
alternative
sources
of
starch
for
drug
delivery.
Traditional
options
like
corn,
potato,
and
rice
starches
widely
used,
but
sustainability
concerns
prompted
the
investigation
nonconventional
starches.
Elephant
foot
yam
starch,
derived
from
an
agricultural
polymer,
has
gained
popularity
due
to
its
wide
availability.
Starches
are
fundamentally
unsuited
majority
applications;
they
must
be
physically
and/or
chemically
altered
maximize
their
advantages
minimize
drawbacks.
Due
chemical
toxicity,
modification
is
often
done
using
physical
techniques
that
inexpensive.
This
study
aims
evaluate
impact
elephant
on
physicochemical
properties
delivery
potato
starch.
Pregelatinization,
a
crucial
process,
found
increase
amylose
content
improves
flow
properties,
as
confirmed
by
Fourier‐transform
infrared
spectroscopy
analysis
showing
gelatinization
in
mixture.
Field
emission
scanning
electron
microscopy
images
reveal
complete
disruption
granular
structure
after
modification.
Tablets
made
with
mixture
pregelatinized
exhibit
slower
release
compared
those
alone.
Notably,
inclusion
results
more
sustained
release.
Hence,
modified
diverse
applications
enhancing
solubility
poorly
soluble
drugs.
Artificial Cells Nanomedicine and Biotechnology,
Год журнала:
2024,
Номер
52(1), С. 564 - 586
Опубликована: Дек. 5, 2024
Cancer
has
a
high
rate
of
incidence
and
mortality
throughout
the
world.
Although
several
conventional
approaches
have
been
developed
for
treatment
cancer,
such
as
surgery,
chemotherapy,
radiotherapy
thermal
therapy,
they
remarkable
disadvantages
which
result
in
inefficient
cancer.
For
example,
immunogenicity,
prolonged
treatment,
non-specificity,
metastasis
cost
are
considered
major
drawbacks
chemotherapy.
Therefore,
there
is
fundamental
requirement
development
breakthrough
technologies
cancer
suppression.
Polysaccharide-based
drug
delivery
systems
(DDSs)
most
reliable
carriers
therapy.
Polysaccharides,
kind
practical
biomaterials,
divided
into
types,
including
chitosan,
alginates,
dextran,
hyaluronic
acid,
cyclodextrin,
pectin,
etc.
Polysaccharides
extracted
from
different
natural
resources
(like
herbal,
marine,
microorganisms,
etc.).
The
potential
features
polysaccharides
made
them
candidates
therapeutics
to
sites;
simple
purification,
ease
modification
functionalization,
hydrophilicity,
serum
stability,
appropriate
loading
capacity,
biocompatibility,
bioavailability,
biodegradability
stimuli-responsive
sustained
release
manner
considerable
aspects
these
biopolymers.
This
review
highlights
applications
polysaccharides-based
DDSs
pharmaceutical
science
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 138855 - 138855
Опубликована: Дек. 1, 2024
Plant-derived
bioactive
polysaccharides
(PDBPs),
versatile
polymers
originating
from
various
botanical
sources,
exhibit
a
spectrum
of
biological
functionalities
crucial
for
human
health.
This
review
delves
into
the
multifaceted
roles
these
compounds,
elucidating
their
immune-boosting
properties,
antioxidant
prowess,
anti-inflammatory
capabilities,
and
contributions
to
gut
Amidst
pivotal
roles,
efficiency
PDBPs
delivery
bioavailability
in
system
stands
as
central
determinant
efficacy
utilization.
paper
extensively
systematically
examines
diverse
activities,
such
immunomodulatory
effects,
mechanisms
like
microencapsulation,
promising
applications
within
realms
both
food
(functional
foods
nutraceuticals)
pharmaceutical
(antimicrobial
agents
drugs)
sectors.
Additionally,
it
offers
comprehensive
overview
classification,
structural
diversity
polysaccharides,
highlighting
identification
techniques
rheological
considerations.
Moreover,
addresses
critical
safety
regulatory
concerns
alongside
global
legislation
about
plant
envisaging
broader
landscape
Through
this
synthesis,
we
aim
underscore
holistic
significance
potential
revolutionize
nutritional
therapeutic
paradigms.
Reactive and Functional Polymers,
Год журнала:
2024,
Номер
196, С. 105841 - 105841
Опубликована: Янв. 26, 2024
Applications
of
sodium
alginate
(Alg)
and
polyacrylic
acid
(PAA)
hydrogels
in
biomedicine
are
well-known.
These
predefined
by
the
strength
weakness
their
properties,
which
turn
depend
on
chemical
structure
architecture
crosslinks.
In
this
work,
Alg
biopolymer
has
been
grafted
to
synthetic
PAA
that
chemically
crosslinked
using
N,N′-methylene-bisacrylamide
(MBA)
produce
a
pH
responsive
hydrogel
with
adhesive
property.
The
double
crosslinking
network,
combines
MBA-mediated
covalent
crosslinks
ionic
domains,
results
an
elastic
modulus
resembles
highly
anisotropic
viscoelastic
human
skin.
After
addressing
influence
dual
network
onto
Alg-g-PAA
prospection
its
potential
as
made
considering
different
surfaces
(rubber,
paper
steel,
porcine
skin,
etc).
bonding
energy
32.6
±
4.6
J/m2,
revealed
can
be
proposed
biomedical
field
tissue
for
wound
healing
applications.
Finally,
semi-interpenetrated
poly(hydroxymethyl-3,4-ethylenedioxythiophene)
(PEDOT-MeOH)
chains
through
oxidative
polymerization
process.
resulting
hydrogel,
Alg-g-PAA/PEDOT-MeOH,
is
even
more
porous
than
Alg-g-PAA,
addition
being
electro-responsive,
maintains
properties.
