Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
The
skin
is
fragile,
making
it
very
vulnerable
to
damage
and
injury.
Untreated
wounds
can
pose
a
serious
threat
human
health.
Three-dimensional
polymer
network
hydrogels
have
broad
application
prospects
in
wound
dressings
due
their
unique
properties
structure.
therapeutic
effect
of
traditional
limited,
while
multifunctional
composite
show
greater
potential.
Multifunctional
regulate
moisture
through
formula
adjustment.
Moreover,
be
combined
with
bioactive
ingredients
improve
performance
healing
applications.
Stimulus-responsive
respond
specifically
the
environment
meet
needs
different
stages.
This
review
summarizes
material
types,
structure,
properties,
design
considerations,
formulation
strategies
for
hydrogel
used
healing.
We
discuss
various
types
recently
developed
dressings,
highlights
importance
tailoring
physicochemical
addresses
potential
challenges
preparing
dressings.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2024,
Номер
151, С. 106391 - 106391
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(3), С. 91 - 91
Опубликована: Март 5, 2025
Chronic
wound
infections
present
a
persistent
medical
challenge;
however,
advancements
in
dressings
and
antimicrobial
nanomaterials
offer
promising
solutions
for
improving
healing
outcomes.
This
study
introduces
hydrothermal
synthesis
approach
producing
zinc
oxide
(ZnO)
copper
(CuO)
nanoparticles,
subsequently
incorporated
into
PLGA
microspheres
embedded
within
collagen
hydrogels.
The
nanoparticles’
physicochemical
properties
were
characterized
using
X-ray
diffraction
(XRD)
to
confirm
crystalline
structure,
scanning
electron
microscopy
(SEM)
surface
morphology,
Fourier-transform
infrared
spectroscopy
(FT-IR)
verify
functional
groups
successful
hydrogel
integration.
hydrogels
tested
activity
against
Staphylococcus
aureus,
Pseudomonas
aeruginosa,
Candida
albicans,
which
are
key
pathogens
chronic
wounds.
Biocompatibility
was
assessed
the
human
HaCat
keratinocyte
cell
line.
Both
ZnO-
CuO-loaded
exhibited
broad-spectrum
efficacy.
Cytocompatibility
tests
demonstrated
that
both
sustain
viability
proliferation,
highlighting
their
biocompatibility
suitability
applications,
with
superior
biological
performance
of
ZnO-loaded
Furthermore,
distinct
profiles
ZnO
CuO
suggest
tailored
use
based
on
microbial
composition,
excelling
antibacterial
applications
showing
potential
antifungal
treatments.
These
results
underscore
nanoparticle-based
as
innovative
therapeutic
tools
managing
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
96, С. 105689 - 105689
Опубликована: Апрель 21, 2024
In
the
last
few
years,
wound
healing
and
development
of
"ideal"
biomaterials
that
provide
quick
recovery
minimize
scarring
have
represented
one
most
important
priorities
researchers.
this
direction,
silk
fibroin
(SF)
scaffolds
gained
substantial
awareness,
as
a
promising
polymer
owing
to
their
increased
biocompatibility,
outstanding
mechanical
properties,
biodegradability,
especially
tensile
strength.
Furthermore,
SF
is
acknowledged
accelerate
process
by
encouraging
cell
growth
proliferation,
also
migration
different
types
cells
are
included
in
stages
process.
Therefore,
metal
oxide
nanoparticles
(NPs),
such
iron
(FeO),
copper
(CuO),
zinc
(ZnO),
or
magnesium
(MgO)
NPs,
been
extensively
researched
for
antimicrobial
properties
ability
enhance
tissue
regeneration
addition
SF.
When
introduced
within
scaffolds,
these
NPs
impart
enhanced
including
improved
scaffold
stability
durability.
Moreover,
presence
could
increase
biocompatibility
facilitating
adhesion,
migration,
ultimately
promoting
processes.
The
incorporation
other
natural
polymers
into
has
thus
emerged
favorable
method
therapeutic
potential
developed
biomaterial.
This
review
aims
an
overview
advancements
containing
applications.
Bioactive Materials,
Год журнала:
2024,
Номер
39, С. 492 - 520
Опубликована: Май 30, 2024
Endogenous
regeneration
is
becoming
an
increasingly
important
strategy
for
wound
healing
as
it
facilitates
skin's
own
regenerative
potential
self-healing,
thereby
avoiding
the
risks
of
immune
rejection
and
exogenous
infection.
However,
currently
applied
biomaterials
inducing
endogenous
skin
are
simplistic
in
their
structure
function,
lacking
ability
to
accurately
mimic
intricate
tissue
regulate
disordered
microenvironment.
Novel
biomimetic
with
precise
structure,
chemical
composition,
biophysical
properties
offer
a
promising
avenue
achieving
perfect
regeneration.
Here,
we
outline
recent
advances
materials
induced
from
aspects
structural
functional
mimicry,
physiological
process
regulation,
property
design.
Furthermore,
novel
techniques
including
situ
reprograming,
flexible
electronic
skin,
artificial
intelligence,
single-cell
sequencing,
spatial
transcriptomics,
which
have
contribute
development
highlighted.
Finally,
prospects
challenges
further
research
application
discussed.
This
review
provides
reference
address
clinical
problems
rapid
high-quality
