Nanomaterials,
Год журнала:
2024,
Номер
14(24), С. 2018 - 2018
Опубликована: Дек. 16, 2024
Nanoparticles
(NPs)
have
emerged
as
a
potent
choice
for
various
applications,
from
drug
delivery
to
agricultural
studies,
serving
an
alternative
and
promising
methodology
future
advancements.
They
been
widely
explored
in
systems,
demonstrating
immense
promise
high
efficiency
the
of
numerous
biomolecules
such
proteins
anticancer
agents,
either
solely
or
modified
with
other
compounds
enhance
their
capabilities.
In
addition,
utilization
NPs
extends
antimicrobial
where
they
are
used
develop
novel
antibacterial,
antifungal,
antiviral
formulations
advanced
characteristics.
Lactoferrin
(Lf)
is
glycoprotein
recognized
its
significant
multifunctional
properties,
antimicrobial,
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective
effects.
Its
activity
has
broad
distribution
human
body,
Lf
receptors
present
multiple
regions.
Current
research
shows
that
utilized
NP
technology
surface
material,
encapsulated
biomolecule,
even
itself.
Due
abundance
regions,
can
be
employed
material
targeted
strategies,
particularly
crossing
BBB
targeting
specific
cancers.
Furthermore,
synthesized
structure,
positioning
it
strong
candidate
NP-related
applications.
this
article,
we
explore
highlighted
underexplored
areas
applications
research.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 15, 2024
Emerging
infectious
diseases
are
caused
by
unpredictable
viruses
with
the
dangerous
potential
to
trigger
global
pandemics.
These
typically
initiate
infection
utilizing
anionic
structures
of
host
cell
surface
receptors
gain
entry.
Lactoferrin
(Lf)
is
a
multifunctional
glycoprotein
multiple
properties
such
as
antiviral,
anti-inflammatory
and
antioxidant
activities.
Due
its
cationic
structure,
Lf
naturally
interacts
certain
receptors,
heparan
sulfate
proteoglycans,
well
viral
particles
other
that
targeted
viruses.
Therefore,
may
interfere
virus-host
interactions
acting
receptor
competitor
for
Herein
we
summarize
studies
in
which
this
competition
was
investigated
SARS-CoV-2,
Zika,
Dengue,
Hepatitis
Influenza
vitro
.
have
demonstrated
not
only
Lf’s
competitive
properties,
but
also
intracellular
impact
on
cells,
enhancing
survival
reducing
efficiency
inhibiting
enzymes.
In
addition,
immunomodulatory
effect
highlighted,
it
can
influence
activity
specific
immune
cells
regulate
cytokine
release,
thereby
host’s
response
infections.
Collectively,
these
promote
promising
candidate
research
diseases.
Nutrients,
Год журнала:
2025,
Номер
17(1), С. 197 - 197
Опубликована: Янв. 6, 2025
Organ
fibrosis
is
gradually
becoming
a
human
health
and
safety
problem,
various
organs
of
the
body
are
likely
to
develop
fibrosis.
The
ultimate
pathological
feature
numerous
chronic
diseases
fibrosis,
few
interventions
currently
available
specifically
target
pathogenesis
medical
detection
organ
has
matured.
However,
there
no
effective
treatment
method
for
these
diseases.
Therefore,
we
need
strive
developing
reliable
drugs
or
substances
treat
prevent
fibrotic
Lactoferrin
(LF)
multifunctional
glycoprotein
with
many
physiologically
active
effects,
such
as
antioxidant,
anti-inflammatory
antimicrobial
it
protects
against
physiological
conditions
in
disease
models.
This
review
summarizes
effects
underlying
mechanisms
LF
preventing
As
naturally
substance,
can
be
used
promising
drug
prevention
remission
Journal of Genetic Engineering and Biotechnology,
Год журнала:
2025,
Номер
23(1), С. 100466 - 100466
Опубликована: Фев. 21, 2025
Due
to
bleomycin's
cytotoxic
characteristics,
which
include
cardiotoxicity,
this
investigation
looked
at
the
effectiveness
of
costus
ethanolic
extract
in
reducing
cardiotoxicity
male
rats
receiving
bleomycin
therapy.
Forty
adult
(160-200
g)
were
evenly
allocated
into
four
groups:
group
(1)
included
normal
serving
as
control;
(2)
administered
200
mg/kg
(CEE)
orally
for
6
weeks;
(3)
consisted
(15
twice
weekly,
ip)
and
(4)
involved
treated
with
CEE
(200
mg/kg/day)
weeks
following
intoxication.
The
results
indicated
that
significantly
reversed
cardiological
deteriorations
brought
on
by
bleomycin;
was
demonstrated
a
considerable
increase
cardiac
SOD,
GPx,
GSH,
CAT,
along
substantial
decrease
MDA,
NO,
DNA
fragmentation.
Also,
serum,
LDH,
CK-MB,
CK-
total,
TNF-α,
IL-4,
IL-6
IL-10,
IL-1β,
triglycerides,
cholesterol,
LDL
reduced,
while
CD4
levels
increased,
HDL
declined
significantly.
histological
immunohistochemical
analyses
revealed
notable
regeneration.
In
conclusion,
CEE's
anti-cardiotoxic,
anti-inflammatory,
antioxidant
properties
prove
its
ability
be
cardio-protective
supplement.
This
may
mediated
active
constituents'
radical
scavenging
properties,
particularly
high
phenolic
content.
Coatings,
Год журнала:
2024,
Номер
14(1), С. 125 - 125
Опубликована: Янв. 17, 2024
The
purpose
of
this
research
was
to
analyze
the
antiviral
activity
coatings
based
on
ZnO
nanoparticles
and
TiO2.
goal
also
investigate
influence
accelerated
UV-B
Q-SUN
irradiation
their
effectiveness.
results
performed
analysis
demonstrated
that
only
one
four
containing
high
activity.
had
a
positive
properties
other
three
coatings.
After
24
h
irradiation,
these
moderate
effectiveness,
confirming
improved
active
layers
(by
activating
TiO2).
Unfortunately,
after
48
decreased,
time
should
not
be
too
long.
Comparing
coating
it
has
mentioned
(24
h)
coatings,
which
were
before
irradiation.
However,
decreased
UV
aging.
none
those
analyzed
shorter.
Journal of Functional Foods,
Год журнала:
2024,
Номер
117, С. 106237 - 106237
Опубликована: Май 15, 2024
Certain
milk
proteins
and
peptides
exhibit
promising
immunogenic
antiviral
properties,
particularly
against
coronaviruses
like
SARS-CoV-2.
Amidst
the
global
pandemic,
these
bioactive
components
present
potential
alternatives
for
combating
viral
diseases.
Milk
are
known
to
play
important
roles
functioning
in
various
stages
of
SARS-CoV-2
replication
cycle,
including
entry,
endocytic
processes,
replication,
cell
signaling
modulation.
Notably,
bovine
lactoferrin,
is
reported
synergistically
enhance
effects
remdesivir,
an
FDA-approved
anti-SARS-CoV-2
drug.
Peptides
derived
from
have
demonstrated
some
efficacy
both
vitro
silico
studies.
While
findings
highlight
as
natural
agents,
further
validation
through
vivo
studies
clinical
trials
imperative
determine
their
efficacy,
safety,
optimal
dosages.
This
review
provides
a
comprehensive
exploration
specific
peptides.
