Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture DOI Creative Commons
Emir Akdaşçi, Furkan Eker, Hatice Duman

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(24), P. 2018 - 2018

Published: Dec. 16, 2024

Nanoparticles (NPs) have emerged as a potent choice for various applications, from drug delivery to agricultural studies, serving an alternative and promising methodology future advancements. They been widely explored in systems, demonstrating immense promise high efficiency the of numerous biomolecules such proteins anticancer agents, either solely or modified with other compounds enhance their capabilities. In addition, utilization NPs extends antimicrobial where they are used develop novel antibacterial, antifungal, antiviral formulations advanced characteristics. Lactoferrin (Lf) is glycoprotein recognized its significant multifunctional properties, antimicrobial, antioxidant, anti-inflammatory, anticancer, neuroprotective effects. Its activity has broad distribution human body, Lf receptors present multiple regions. Current research shows that utilized NP technology surface material, encapsulated biomolecule, even itself. Due abundance regions, can be employed material targeted strategies, particularly crossing BBB targeting specific cancers. Furthermore, synthesized structure, positioning it strong candidate NP-related applications. this article, we explore highlighted underexplored areas applications research.

Language: Английский

The use of proteins and peptides-based therapy in managing and preventing pathogenic viruses DOI
Esmail M. El‐Fakharany, Hamada El‐Gendi, Ahmed K. Saleh

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132254 - 132254

Published: May 9, 2024

Language: Английский

Citations

7
The potential of lactoferrin as antiviral and immune-modulating agent in viral infectious diseases DOI Creative Commons
Furkan Eker, Hatice Duman, Melih Ertürk

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 15, 2024

Emerging infectious diseases are caused by unpredictable viruses with the dangerous potential to trigger global pandemics. These typically initiate infection utilizing anionic structures of host cell surface receptors gain entry. Lactoferrin (Lf) is a multifunctional glycoprotein multiple properties such as antiviral, anti-inflammatory and antioxidant activities. Due its cationic structure, Lf naturally interacts certain receptors, heparan sulfate proteoglycans, well viral particles other that targeted viruses. Therefore, may interfere virus-host interactions acting receptor competitor for Herein we summarize studies in which this competition was investigated SARS-CoV-2, Zika, Dengue, Hepatitis Influenza vitro . have demonstrated not only Lf’s competitive properties, but also intracellular impact on cells, enhancing survival reducing efficiency inhibiting enzymes. In addition, immunomodulatory effect highlighted, it can influence activity specific immune cells regulate cytokine release, thereby host’s response infections. Collectively, these promote promising candidate research diseases.

Language: Английский

Citations

6
Comprehensive structural and functional analysis of Patuletin as a potent inhibitor of SARS-CoV-2 targeting the RNA-dependent RNA polymerases DOI
Ahmed M. Metwaly, Esmail M. El‐Fakharany, Aisha A. Alsfouk

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1311, P. 138424 - 138424

Published: April 24, 2024

Language: Английский

Citations

4
The Novel Effect and Potential Mechanism of Lactoferrin on Organ Fibrosis Prevention DOI Open Access
Yonghui Yu, Juan Fang, Yingying Li

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(1), P. 197 - 197

Published: Jan. 6, 2025

Organ fibrosis is gradually becoming a human health and safety problem, various organs of the body are likely to develop fibrosis. The ultimate pathological feature numerous chronic diseases fibrosis, few interventions currently available specifically target pathogenesis medical detection organ has matured. However, there no effective treatment method for these diseases. Therefore, we need strive developing reliable drugs or substances treat prevent fibrotic Lactoferrin (LF) multifunctional glycoprotein with many physiologically active effects, such as antioxidant, anti-inflammatory antimicrobial it protects against physiological conditions in disease models. This review summarizes effects underlying mechanisms LF preventing As naturally substance, can be used promising drug prevention remission

Language: Английский

Citations

0
Functionalization of surgical mask polypropylene layers with application of natural substances DOI Creative Commons
Marjana Simonič, Olivija Plohl, Martina Vračević

et al.

Iranian Polymer Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

Citations

0
Cardioprotective, anti-inflammatory, and antioxidative outcome of costus against bleomycin-induced cardiotoxicity in rat model DOI Creative Commons

Barakat M. Alrashdi,

Hussam Askar,

Mousa O. Germoush

et al.

Journal of Genetic Engineering and Biotechnology, Journal Year: 2025, Volume and Issue: 23(1), P. 100466 - 100466

Published: Feb. 21, 2025

Due to bleomycin's cytotoxic characteristics, which include cardiotoxicity, this investigation looked at the effectiveness of costus ethanolic extract in reducing cardiotoxicity male rats receiving bleomycin therapy. Forty adult (160-200 g) were evenly allocated into four groups: group (1) included normal serving as control; (2) administered 200 mg/kg (CEE) orally for 6 weeks; (3) consisted (15 twice weekly, ip) and (4) involved treated with CEE (200 mg/kg/day) weeks following intoxication. The results indicated that significantly reversed cardiological deteriorations brought on by bleomycin; was demonstrated a considerable increase cardiac SOD, GPx, GSH, CAT, along substantial decrease MDA, NO, DNA fragmentation. Also, serum, LDH, CK-MB, CK- total, TNF-α, IL-4, IL-6 IL-10, IL-1β, triglycerides, cholesterol, LDL reduced, while CD4 levels increased, HDL declined significantly. histological immunohistochemical analyses revealed notable regeneration. In conclusion, CEE's anti-cardiotoxic, anti-inflammatory, antioxidant properties prove its ability be cardio-protective supplement. This may mediated active constituents' radical scavenging properties, particularly high phenolic content.

Language: Английский

Citations

0
Green synthesis, characterization, anti-SARS-CoV-2 entry, and replication of lactoferrin-coated zinc nanoparticles with halting lung fibrosis induced in adult male albino rats DOI Creative Commons
Esmail M. El‐Fakharany, Yousra A. El‐Maradny, Mahmoud Ashry

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 23, 2023

Abstract The ethanolic extract of Coleus forskohlii Briq leaves was employed in the green synthesis zinc nanoparticles (Zn-NPs) by an immediate, one-step, and cost-effective method present study. Zn-NPs were coated with purified bovine lactoferrin (LF) characterized through different instrumental analysis. biosynthesized white color revealing oval to spherical-shaped particles average size 77 ± 5.50 nm, whereas LF-coated (LF-Zn-NPs) revealed a larger up 98 6.40 nm. LF-Zn-NPs negatively charged surfaces zeta-potentials – 20.25 0.35 44.3 3.25 mV, respectively. Interestingly, showed potent vitro retardation for SARS-CoV-2 entry host cells binding ACE2-receptor spike protein receptor domain at IC 50 values 59.66 μg/mL, Additionally, results indicated ability inhibit replication interfering RNA-dependent RNA polymerase “RdRp” activity 49.23 μg/mL. In vivo, displayed protective therapeutic against induced pulmonary fibrosis Bleomycin-treated male albino rats owing its anti-inflammatory, antioxidant, significant reduction CRP, LDH, ferritin, D-dimer levels. obtained findings offer promising route as candidates COVID-19.

Language: Английский

Citations

10
Phyto-mediated synthesis of zinc oxide nanoparticles from Clerodendrum infortunatum L. leaf extract and evaluation of antibacterial potential DOI
Sahil Kumar,

Navneet Bithel,

Sunil Kumar

et al.

South African Journal of Botany, Journal Year: 2023, Volume and Issue: 164, P. 146 - 151

Published: Dec. 2, 2023

Language: Английский

Citations

9
The Influence of the Q-SUN and UV-B Irradiation on the Antiviral Properties of the PP Films Covered with the Coatings Based on ZnO Nanoparticles and TiO2 DOI Open Access
Małgorzata Mizielińska, Artur Bartkowiak

Coatings, Journal Year: 2024, Volume and Issue: 14(1), P. 125 - 125

Published: Jan. 17, 2024

The purpose of this research was to analyze the antiviral activity coatings based on ZnO nanoparticles and TiO2. goal also investigate influence accelerated UV-B Q-SUN irradiation their effectiveness. results performed analysis demonstrated that only one four containing high activity. had a positive properties other three coatings. After 24 h irradiation, these moderate effectiveness, confirming improved active layers (by activating TiO2). Unfortunately, after 48 decreased, time should not be too long. Comparing coating it has mentioned (24 h) coatings, which were before irradiation. However, decreased UV aging. none those analyzed shorter.

Language: Английский

Citations

2
Antiviral properties of milk proteins and peptides against SARS-COV-2: A review DOI Creative Commons
Parminder Singh, Janak Dhakal, Pavan Kumar

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 117, P. 106237 - 106237

Published: May 15, 2024

Certain milk proteins and peptides exhibit promising immunogenic antiviral properties, particularly against coronaviruses like SARS-CoV-2. Amidst the global pandemic, these bioactive components present potential alternatives for combating viral diseases. Milk are known to play important roles functioning in various stages of SARS-CoV-2 replication cycle, including entry, endocytic processes, replication, cell signaling modulation. Notably, bovine lactoferrin, is reported synergistically enhance effects remdesivir, an FDA-approved anti-SARS-CoV-2 drug. Peptides derived from have demonstrated some efficacy both vitro silico studies. While findings highlight as natural agents, further validation through vivo studies clinical trials imperative determine their efficacy, safety, optimal dosages. This review provides a comprehensive exploration specific peptides.

Language: Английский

Citations

1