Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(6)
Опубликована: Апрель 25, 2024
Cancer
has
become
the
second
leading
reason
for
death
in
world.
Cell
biology
states
that
bulk
of
anti‐cancer
medications
focuses
on
DNA.
A
study
how
complexes
metals
interact
with
DNA
is
crucial
creation
effective
chemotherapy
drugs.
The
interactions
Schiff
base
and
their
metal
are
a
thrust
area
many
researchers,
papers
have
reported
them.
An
amino
molecule
reacts
carbonyl
group
to
form
variety
chemicals
called
bases.
Many
studies
shown
bases
compounds
affect
biological
processes.
Due
potential
use
as
novel
reagents
biotechnology
medicine,
research
between
transition
nucleic
acids
grown
significantly
during
past
few
decades.
It
was
several
may
intercalate
Small
molecules
can
attach
themselves
through
different
ways,
such
intercalation
groove
binding.
main
method
measure
nuclease
activity
gel
electrophoresis,
ligand
alone
had
much
lower
than
complex.
To
set
stage
this
analysis,
brief
overview
provided.
Further,
review
provides
an
brought
forth
by
complexes.
also
draws
attention
new
developments
prospective
bioactive
core
cleavage
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(3)
Опубликована: Фев. 18, 2025
ABSTRACT
The
complexes
of
[Zn
(DAP)(SA)]
(
1
)
and
(bpy)(DAP)]Cl
2
(where
DAP
is
3,4‐diaminobenzophenone,
SA
a
dianion
salicylate,
bpy
2,2′‐bipyridine)
were
synthesized
characterized
using
various
techniques
such
as
H
NMR,
ESI‐Mass,
13
C
FT‐IR,
thermal
gravimetric
analysis
(TGA),
UV–Vis.
formation
these
was
supported
by
theoretical
DFT
approach.
It
reveals
that
have
tetrahedral
geometry.
interaction
with
CT‐DNA
studied
different
methods.
UV–Vis
titration
revealed
bathochromic
shift
significant
hypochromicity
at
260
nm
for
the
absorption
band
in
presence
complexes.
studies
this
work
showed
intercalative
between
not
main
or
strongest
mode,
but
other
modes
groove
binding
play
role
their
interactions.
achieved
results
from
viscosity
electrochemical
measurement
confirmed
finding.
fluorescence
proposed
mechanism
quenching
both
static
quenching.
thermodynamic
parameters
(Δ
°
Δ
S
°)
complex
DNA
occurs
through
hydrophobic
forces
via
hydrogen
bonding
van
der
Waals
interaction.
antioxidant
activity
investigated
DPPH
(2,2‐Diphenyl‐1‐picrylhydrazyl)
assay.
According
to
test,
compared
standard
sample
(vitamin
C)
follows:
vitamin
>
.
Furthermore,
docking
result
DNA.
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(4)
Опубликована: Март 5, 2025
ABSTRACT
In
this
study,
axially
substituted
silicon
(IV)
phthalocyanine
complexes
containing
pyrimidine‐substituted
Schiff
bases
were
synthesized
and
characterized.
The
(
Pyr‐1
Pyr‐2
)
through
a
condensation
reaction
between
pyrimidine
derivatives
appropriate
aldehydes,
followed
by
their
coordination
with
to
form
the
corresponding
Pyr‐1‐SiPc
Pyr‐2‐SiPc
).
subsequently
tested
in
vivo
for
inhibitory
effect
on
enzymes
acetylcholinesterase
(AChE)
butyrylcholinesterase
(BChE).
A
substantial
number
of
these
compounds
exhibited
pronounced
activity
against
both
enzymes.
Notably,
among
phthalocyanines
precursor
compounds,
most
intriguing
identified
as
submicromolar
selective
inhibitors
AChE
BChE,
IC
50
values
4.26
μM
6.46
μM,
respectively.
