Bioengineering,
Год журнала:
2024,
Номер
11(12), С. 1278 - 1278
Опубликована: Дек. 16, 2024
Antibiotic
therapy
has
been
a
common
method
for
treating
bacterial
infections
over
the
past
century,
but
with
rise
in
resistance
caused
by
antibiotic
abuse,
better
control
and
more
rational
use
of
antibiotics
have
increasingly
demanded.
At
same
time,
journey
to
explore
alternatives
therapies
also
undertaken.
Chitosan
its
derivatives,
materials
good
biocompatibility,
biodegradability,
excellent
antibacterial
properties,
garnered
significant
attention,
studies
on
chitosan
derivatives
conducted
recent
years.
In
this
work,
we
aim
elucidate
biological
properties
track
their
clinical
applications,
as
well
propose
issues
that
need
be
addressed
possible
solutions
further
future
development
application.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(30)
Опубликована: Июль 22, 2024
Abstract
Due
to
repeated
microbial
infection,
persistent
inflammation,
excessive
oxidative
stress,
and
cell
dysfunction,
chronic
wounds
are
difficult
heal,
posing
a
serious
threat
public
health.
Therefore,
developing
multifunctional
wound
dressings
that
can
regulate
the
complex
microenvironment
of
enhance
cellular
function
holds
great
significance.
Recently,
chitosan
has
emerged
as
promising
biopolymer
for
healing
due
its
excellent
biocompatibility,
biodegradability,
versatile
bioactivity.
The
aim
this
review
is
provide
comprehensive
understanding
mechanisms
delayed
discuss
healing–promoting
properties
derivatives,
such
good
antibacterial
activity,
hemostatic
capacity,
ability
promote
tissue
regeneration.
On
basis,
potential
applications
chitosan‐based
hydrogels
summarized
in
healing,
including
providing
suitable
microenvironment,
eliminating
bacterial
infections,
promoting
hemostasis,
inhibiting
alleviating
In
addition,
concerns
perspectives
clinical
application
also
discussed.
LWT,
Год журнала:
2024,
Номер
193, С. 115762 - 115762
Опубликована: Янв. 16, 2024
Photodynamic
sterilization
has
been
regarded
as
a
promising
alternative
to
conventional
antibacterial
approaches.
However,
the
photodynamic
efficiency
of
photosensitizer
is
often
compromised
by
aggregation-induced
quenching
effects.
Photosensitizers,
especially
natural
products,
with
emission
(AIE)
properties
open
new
avenue
for
sterilization.
Herein,
we
investigated
performance
and
mechanism
AIE-type
product
berberine
(BBR)
against
Listeria
monocytogenes
(L.
monocytogenes).
The
bactericidal
effect
was
assessed
through
determination
minimum
concentration
implementation
anti-biofilm
experiments.
results
showed
that
BBR
can
significantly
suppress
proliferation
L.
efficiently
remove
monocytogenes-derived
biofilm
in
concentration-dependent
trend.
killing
speculated
based
on
bacterial
morphology
characterization,
viability
staining
results,
enzyme
activity
assays,
DNA
electrophoresis
analysis,
molecular
docking.
excellent
anti-bacterial
mediated
process
may
account
its
abilities
irreversibly
disruption
membrane,
inhibition
intracellular
decomposition
molecules.
We
also
demonstrated
embedded
sodium
alginate/chitosan
packaging
film
feasible
maintain
freshness
salmon
under
light
illumination
inhibiting
proliferation.
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e25604 - e25604
Опубликована: Фев. 1, 2024
Gentamicin
(GEN),
a
widely
used
broad-spectrum
antibiotic,
faces
challenges
amid
the
global
emergency
of
antimicrobial
resistance.
This
study
aimed
to
explore
synergistic
effects
zinc
oxide
nanoparticles
(ZnO
NPs)
in
combination
with
GEN
on
bactericidal
activity
against
various
bacterial
strains.
Results
showed
ZnO
NPs
MICs
ranging
from
0.002
1.5
μg/mL,
while
precursor
salt
displayed
MIC
range
48.75–1560
μg/mL.
Chitosan
(CS)-capped
exhibited
even
lower
than
their
uncapped
counterparts,
CS-capped
synthesized
demonstrating
lowest
values.
Minimal
concentrations
(MBC)
aligned
trends.
Combinations
and
proved
highly
effective,
inhibiting
growth
at
significantly
or
alone.
phenomenon
may
be
attributed
conformation
CS
NPs'
surface,
enhancing
positive
particle
surface
charge.
possibly
facilitates
more
effective
interaction
between
microorganisms,
leading
increased
accumulation
within
cells
an
overproduction
reactive
oxygen
species
(ROS).
It's
crucial
note
that,
this
did
not
specifically
involve
resistant
strains,
its
primary
focus
remains
overall
gentamicin.
The
research
aims
contribute
addressing
challenge
resistance,
recognizing
urgent
need
for
strategies
combat
critical
issue.
findings,
particularly
observed
synergy
GEN,
hold
significant
implications
repositioning
first-line
antibiotic
GEN.
Bioengineering,
Год журнала:
2024,
Номер
11(2), С. 177 - 177
Опубликована: Фев. 11, 2024
Drug
resistance
substantially
compromises
antibiotic
therapy
and
poses
a
serious
threat
to
public
health.
Fusidic
acid
(FA)
is
commonly
used
treat
staphylococcal
infections,
such
as
pneumonia,
osteomyelitis
skin
infections.
However,
Gram-negative
bacteria
have
natural
FA,
which
almost
restrained
in
cell
membranes
due
the
strong
interactions
between
FA
phospholipids.
Herein,
we
aim
utilize
FA–phospholipid
interaction
pre-form
complex
of
with
exogenous
phospholipid.
The
form
an
(FA-PC),
no
longer
interacts
endogenous
membrane
phospholipids
thus
can
be
delivered
into
cells
successfully.
We
found
that
water
solubility
(5
µg/mL)
was
improved
133
µg/mL
by
forming
FA-PC
(molar
ratio
1:1).
Furthermore,
upon
incubation
for
6
h,
(20
caused
99.9%
viability
loss
E.
coli
99.1%
P.
aeruginosa,
while
free
did
not
work.
morphology
elongated
after
treatment
demonstrated
SEM.
successful
intracellular
delivery
shown
confocal
laser
scanning
microscopy
coumarin
6-PC
(C6-PC),
where
C6
served
fluorescent
probe.
Interestingly,
antibacterial
effect
significantly
compromised
adding
extra
phospholipid
medium,
indicating
there
may
phospholipid-based
transmembrane
transport
mechanism
underlying
FA-PC.
This
first
report
regarding
formation
its
reversing
it
provides
platform
reverse
delivery-related
drug
resistance.
ready
availability
simple
preparation
allow
great
potential
clinical
use.
ACS Applied Polymer Materials,
Год журнала:
2024,
Номер
6(13), С. 7827 - 7839
Опубликована: Июнь 24, 2024
Bacterial
infection
is
a
severe
challenge
faced
by
artificial
bone
transplantation,
which
might
cause
delayed
healing
or
even
transplant
failure.
Photodynamic
therapy
(PDT)
has
garnered
widespread
attention
as
treatment
for
infections
due
to
its
noninvasiveness,
few
side
effects,
and
high
spatiotemporal
selectivity.
Nevertheless,
owing
the
bacterial
membrane
obstacle,
it
difficult
exogenous
reactive
oxygen
species
(ROS)
penetrate
into
bacteria,
leads
an
unsatisfactory
antibacterial
effect.
Herein,
heterojunction
of
Ti2C3
nanosheets/tin
disulfide
(MXene/SnS2)
designed,
integrates
photothermal
photodynamic
properties.
Then,
MXene/SnS2
was
incorporated
poly-l-lactic
acid
powder
(PLLA)
matrix
fabricate
scaffold
with
selective
laser
sintering
(SLS)
technology.
Under
near-infrared
irradiation,
SnS2
can
strengthen
light
absorption
MXene
generate
local
hyperthermia,
thus
enhancing
permeability.
Meanwhile,
enhances
charge
transfer
inhibits
electron–hole
pair
separation,
thereby
generating
more
ROS
that
interior.
The
results
indicated
this
strategy
effective
activity,
rate
reached
over
90%.
Overall,
research
presents
attractive
implant-related
infection.
Metals,
Год журнала:
2023,
Номер
13(12), С. 1955 - 1955
Опубликована: Ноя. 29, 2023
The
orthodontic
supply
market
is
a
prosperous
billion-dollar
industry,
driven
by
an
increasing
demand
for
appliances.
supremacy
of
metallic
first-generation
biomaterials
evident
manufacturing
brackets,
archwires,
bands,
and
other
components
due
to
their
well-recognized
chemical
inertness,
spontaneous
passivation,
biocompatibility,
favorable
mechanical
properties
combination.
However,
the
oral
cavity
ultimate
corrosion-promoting
environment
any
material.
In
this
work,
general
picture
intraoral
degradation
fixed
appliances
first
addressed,
from
causes
harmful
effects
clinical
implications.
Current
mitigation
strategies
are
also
pointed
out,
including
alloys’
bulk
composition
adjustment
combined
with
new
advanced
processes
and/or
surface
treatment
or
coating
deposition.
versatile
use
thin
films
coatings
stands
out
different
deposition
technologies:
Many
in
vivo
vitro
efforts
have
been
devoted
aging,
monolithic
composite
architectures
micro-
nano-scale
materials,
meet
best
safest
practice
demands.
Unfortunately,
literature
data
suggest
that
even
existing
commercially
available
protective
drawbacks
fallible.
Further
multidisciplinary
research
still
required
effectively
mitigate
corrosion
behavior
